YS 49

ChemicalBook > CAS DataBase List > YS 49

Product Name: YS 49
CAS No.: 132836-42-1
Chemical Name: YS 49
Synonyms: YS 49;CS-884;YS 49;YS49;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide;1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate;inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor
CBNumber: CB41390234
Molecular Formula: C20H20BrNO2
Formula Weight: 386.2823
MOL File: 132836-42-1.mol

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YS 49 Property

storage temp.: 2-8°C
solubility: H2O: >10mg/mL
form: solid
color: White to off-white

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Safety

Hazard Codes: Xn,N
Risk Statements: 22-50
Safety Statements: 61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y1521
Product name: YS-49 monohydrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $213
Updated: 2022/05/15

Axon Medchem

Product number: Axon1685
Product name: YS49
Purity: 98%
Packaging: 10mg
Price: $148.5
Updated: 2021/12/16

AK Scientific

Product number: 3028AH
Product name: 1-(Naphthalen-1-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diolhydrobromide
Packaging: 1mg
Price: $152
Updated: 2021/12/16

ChemScene

Product number: CS-1002
Product name: YS-49
Purity: 95.38%
Packaging: 10mg
Price: $158
Updated: 2021/12/16

ChemScene

Product number: CS-2288
Product name: YS-49 monohydrate
Purity: >98.0%
Packaging: 10mg
Price: $158
Updated: 2021/12/16

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YS 49 Chemical Properties,Usage,Production

Biological Activity

YS-49 is an activator of PI3K/Akt, a downstream target of RhoA, and reduces RhoA/PTEN activation in 3-methylcholine-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated VSMC proliferation by inducing heme oxygenase (HO-1). YS-49 is an isoquinoline compound alkaloid with strong positive inotropic effects due to its ability to activate cardiac β-adrenoceptors.

in vitro

YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC ₅₀ values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.

Cell Viability Assay

Cell Line:	RAVSMC and RAW 264.7 cells
Concentration:	10 μM, 30 μM and 100 μM (RAVSMC cells); 1 μM, 10 μM and 100 μM (RAW 264.7 cells)
Incubation Time:	18 hours
Result:	Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC ₅₀ values of 22 and 30 μM, respectively .

Western Blot Analysis

Cell Line:	RAVSMC and RAW 264.7 cells
Concentration:	10 μΜ, 30 μΜ and 100 μΜ
Incubation Time:	18 hours
Result:	Concentration -dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.

in vivo

YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM. < /p>

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Animal Model:	Male Sprague Dawley rats (250-300 g)
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; 8 hours
Result:	Serum NOx levels were significantly reduced.

YS 49 Preparation Products And Raw materials

Raw materials

Preparation Products

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132836-42-1, YS 49Related Search:

Piperidine, 1-methyl-4,4-bis[(9Z,12Z)-9,12-octadecadien-1-yloxy]- Tetrahydrofurfuryl alcohol 2,2-DIMETHYLTETRAHYDROFURAN YH239-EE Y27632 (hydrochloride) Y320 YKL 06-061 Yhhu-3792 YC-1 YKP-3089 BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy- YS121 YS-035 HYDROCHLORIDE diperdipine

YS 49

1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate

1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-isoquinolinediol hydrobromide

CS-884

YS 49;YS49

inhibit,YS-49,PI3K,Adrenergic Receptor,Phosphoinositide 3-kinase,PKB,Beta Receptor,YS 49,Akt,Protein kinase B,Inhibitor,YS49,Angiotensin Receptor

132836-42-1

C20H19NO2HBr

Akt

mTOR

PI3K

PI3K/Akt/mTOR