liriodenine Property

Melting point:

282°C

Boiling point:

531.0±19.0 °C(Predicted)

Density 

1.501±0.06 g/cm3(Predicted)

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

form 

powder

pka

2.67±0.20(Predicted)

color 

Yellow

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

liriodenine Chemical Properties,Usage,Production

Description

Isolated from the heartwood extract of Liriodendron tulip/era, this base may be purified by crystallization from CHCI3. It contains one methylenedioxy group and a keto group, forming a crystalline oxime, m.p. 271°C. The structure has been confirmed by synthesis, the synthetic alkaloid having a higher melting point of 287°C.

Uses

Liriodenine is an isoquinoline alkaloid found in extracts of medicinal Asian vegetation such as Michelia alba and Liriodendron chinense.

Definition

ChEBI: An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities.

target

p53 | Caspase | Bcl-2/Bax | Sodium Channel | Potassium Channel | Topoisomerase | cAMP

References

Buchanan, Dickey.,J. Org. Chern., 25, 1389 (1960)
Taylor., Tetrahedron, 14,42 (1961)