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CYCLO(-LEU-PRO)

Product Name
CYCLO(-LEU-PRO)
CAS No.
2873-36-1
Chemical Name
CYCLO(-LEU-PRO)
Synonyms
gancidinw;c(Leu-Pro);Maculosin 6;Cyclo(Pro-Leu);CYCLO(-LEU-PRO);cyclo-l-leu-l-pro;Cyclo(L-Pro-D-Leu);Cyclo(L-Pro-L-Leu-);Cyclo(proline-leucine);Cyclo-L-prolyl-L-leucine
CBNumber
CB4142038
Molecular Formula
C11H18N2O2
Formula Weight
210.27
MOL File
2873-36-1.mol
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CYCLO(-LEU-PRO) Property

Melting point:
163-165℃
Boiling point:
427.6±34.0 °C(Predicted)
Density 
1.14
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Solid
pka
13.27±0.40(Predicted)
color 
White to Off-White
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Safety

Toxicity
mouse,LD50,intravenous,80mg/kg (80mg/kg),"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1354, 1978.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3973
Product name
Cyclo(L-Pro-L-Leu)
Packaging
10MG
Price
$102
Updated
2025/07/31
Cayman Chemical
Product number
24941
Product name
Cyclo(L-Leu-L-Pro)
Purity
≥95%
Packaging
5mg
Price
$128
Updated
2024/03/01
Cayman Chemical
Product number
24941
Product name
Cyclo(L-Leu-L-Pro)
Purity
≥95%
Packaging
25mg
Price
$383
Updated
2024/03/01
TRC
Product number
C987660
Product name
Cyclo(L-prolyl-L-leucyl)
Packaging
25mg
Price
$425
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PEP0007072
Product name
CYCLO(L-LEU-L-PRO)
Purity
95.00%
Packaging
5MG
Price
$650
Updated
2021/12/16
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CYCLO(-LEU-PRO) Chemical Properties,Usage,Production

Description

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC50 value of 0.15 mM.

Chemical Properties

White Solid

Uses

Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.

Definition

ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.

References

[1] RHEE K H. Isolation and characterization of Streptomyces sp KH-614 producing anti-VRE (vancomycin-resistant enterococci) antibiotics.[J]. Journal of General and Applied Microbiology, 2002, 48 6: 321-327. DOI: 10.2323/jgam.48.321
[2] XIANCUI LI. Antifouling diketopiperazines produced by a deep-sea bacterium, Streptomyces fungicidicus.[J]. Biofouling, 2006, 22 3-4: 201-208.

CYCLO(-LEU-PRO) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLO(-LEU-PRO) Suppliers

Canada 1 China 96 India 2 United Kingdom 3 United States 10 Global 112
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
ForeChem (Nantong) Technology Co.,Ltd.
Tel
513-85982855 18921614129
Fax
051385915507
Email
sales@xianxingpharm.com
Country
China
ProdList
2986
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
ShenZhen InnoSyn Biotech Co.,Ltd
Tel
0755-28351685 18503098468
Fax
+86-755-28466854
Email
innosyn@163.com
Country
China
ProdList
602
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shenzhen Chim Biotech Co., Ltd.
Tel
13692196024
Fax
0755-28364769
Email
sales@chimchem.com
Country
China
ProdList
501
Advantage
55
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
6905
Advantage
55
Avantpbc Chemical Tech(Shanghai) Co,Ltd.
Tel
17802107445
Country
China
ProdList
185
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
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View Lastest Price from CYCLO(-LEU-PRO) manufacturers

Career Henan Chemical Co
Product
CYCLO(-LEU-PRO) 2873-36-1
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-19

2873-36-1, CYCLO(-LEU-PRO)Related Search:

gypsetin Pyrrolo[1,2-a]pyrazine, octahydro-3-isobutyl- (5CI) CYCLO(-GLY-PRO) (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE CYCLO(-LEU-GLY) hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one VERRUCULOGEN amauromine (S)-1,4-DIAZABICYCLO[4.3.0]NONANE 3-ISOBUTYL-6-METHYL-2,5-PIPERAZINEDIONE CYCLO(-LEU-PRO)

  • 2-a)pyrazine-1,4-dione,hexahydro-3-isobutyl-pyrrolo(stereoisomer
  • 4-dione,hexahydro-3-(2-methylpropyl)-2-a)pyrazine-(3s-trans)-pyrrolo(
  • cyclo-l-leu-l-pro
  • gancidinw
  • (3S-trans)-hexahydro-3-isobutylpyrrolo[1,2-a]pyrazine-1,4-dione
  • (3S,8aS)-2,3,6,7,8,8a-Hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
  • (3S,8aS)-Octahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-leucyl-L-prolyl-)
  • CYCLO(-LEU-PRO)
  • Cyclo(L-Pro-L-Leu-)
  • 3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • 3-isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-quinone
  • (3S-trans)-Hexahydro-3-(2-Methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-Pro-D-Leu)
  • Cyclo(Pro-Leu)
  • Cyclo(proline-leucine)
  • Cyclo-L-prolyl-L-leucine
  • L-Leucyl-L-proline lactaM
  • L-Leucyl-L-prolyl lactaM
  • Maculosin 6
  • (3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)-
  • Cyclo(-L-Leu-L-Pro)≥ 99% (TLC)
  • 3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
  • Cyclo(L-prolyl-L-leucyl)
  • c(Leu-Pro)
  • 2873-36-1