ChemicalBook > CAS DataBase List > CYCLO(-LEU-PRO)

CYCLO(-LEU-PRO)

Product Name: CYCLO(-LEU-PRO)
CAS No.: 2873-36-1
Chemical Name: CYCLO(-LEU-PRO)
Synonyms: gancidinw;c(Leu-Pro);Maculosin 6;Cyclo(Pro-Leu);CYCLO(-LEU-PRO);cyclo-l-leu-l-pro;Cyclo(L-Pro-D-Leu);Cyclo(L-Pro-L-Leu-);Cyclo(proline-leucine);Cyclo-L-prolyl-L-leucine
CBNumber: CB4142038
Molecular Formula: C11H18N2O2
Formula Weight: 210.27
MOL File: 2873-36-1.mol

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CYCLO(-LEU-PRO) Property

Melting point:: 163-165℃
Boiling point:: 427.6±34.0 °C(Predicted)
Density: 1.14
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form: Solid
pka: 13.27±0.40(Predicted)
color: White to Off-White

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Safety

Toxicity: mouse,LD50,intravenous,80mg/kg (80mg/kg),"Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1354, 1978.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3973
Product name: Cyclo(L-Pro-L-Leu)
Packaging: 10MG
Price: $102
Updated: 2025/07/31

Cayman Chemical

Product number: 24941
Product name: Cyclo(L-Leu-L-Pro)
Purity: ≥95%
Packaging: 5mg
Price: $128
Updated: 2024/03/01

Cayman Chemical

Product number: 24941
Product name: Cyclo(L-Leu-L-Pro)
Purity: ≥95%
Packaging: 25mg
Price: $383
Updated: 2024/03/01

TRC

Product number: C987660
Product name: Cyclo(L-prolyl-L-leucyl)
Packaging: 25mg
Price: $425
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0007072
Product name: CYCLO(L-LEU-L-PRO)
Purity: 95.00%
Packaging: 5MG
Price: $650
Updated: 2021/12/16

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CYCLO(-LEU-PRO) Chemical Properties,Usage,Production

Description

Cyclo(L-Leu-L-Pro) is a diketopiperazine metabolite that has been isolated from various bacterial and fungal species including Streptomyces. It is active against twelve strains of vancomycin-resistant enterococci (VRE) with MIC values of 12.5 μg/ml for E. faecalis strains K-99-34, K-00-184, and K-00-221. It also inhibits growth of K562, HL-60, and U937 leukemia cells in a concentration-dependent manner when used at concentrations of 1-500 μg/ml. Cyclo(L-Leu-L-Pro) also has antifouling activity, inhibiting attachment of B. amphitrite larva with an EC₅₀ value of 0.15 mM.

Chemical Properties

White Solid

Uses

Sorbicillin analog. A bioactive secondary metabolites from terrestrial Streptomyces species TN262.

Definition

ChEBI: A homodetic cyclic peptide composed from leucyl and prolyl residues.

References

[1] RHEE K H. Isolation and characterization of Streptomyces sp KH-614 producing anti-VRE (vancomycin-resistant enterococci) antibiotics.[J]. Journal of General and Applied Microbiology, 2002, 48 6: 321-327. DOI: 10.2323/jgam.48.321
[2] XIANCUI LI. Antifouling diketopiperazines produced by a deep-sea bacterium, Streptomyces fungicidicus.[J]. Biofouling, 2006, 22 3-4: 201-208.

CYCLO(-LEU-PRO) Preparation Products And Raw materials

Raw materials

Preparation Products

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CYCLO(-LEU-PRO) Suppliers

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View Lastest Price from CYCLO(-LEU-PRO) manufacturers

Career Henan Chemical Co

Product: CYCLO(-LEU-PRO) 2873-36-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-19

2873-36-1, CYCLO(-LEU-PRO)Related Search:

gypsetin Pyrrolo[1,2-a]pyrazine, octahydro-3-isobutyl- (5CI) CYCLO(-GLY-PRO) (R)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-1(2H)-ONE HEXAHYDROPYRROLO[1,2-A]PYRAZINE-1,4-DIONE (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE CYCLO(-LEU-GLY) hexahydropyrrolo[1,2-a]pyrazin-4(1H)-one VERRUCULOGEN amauromine (S)-1,4-DIAZABICYCLO[4.3.0]NONANE 3-ISOBUTYL-6-METHYL-2,5-PIPERAZINEDIONE CYCLO(-LEU-PRO)

2-a)pyrazine-1,4-dione,hexahydro-3-isobutyl-pyrrolo(stereoisomer

4-dione,hexahydro-3-(2-methylpropyl)-2-a)pyrazine-(3s-trans)-pyrrolo(

cyclo-l-leu-l-pro

gancidinw

(3S-trans)-hexahydro-3-isobutylpyrrolo[1,2-a]pyrazine-1,4-dione

(3S,8aS)-2,3,6,7,8,8a-Hexahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione

(3S,8aS)-Octahydro-3-(2-methylpropyl)pyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(L-leucyl-L-prolyl-)

CYCLO(-LEU-PRO)

Cyclo(L-Pro-L-Leu-)

3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

3-isobutyl-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-quinone

(3S-trans)-Hexahydro-3-(2-Methylpropyl)-pyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(L-Pro-D-Leu)

Cyclo(Pro-Leu)

Cyclo(proline-leucine)

Cyclo-L-prolyl-L-leucine

L-Leucyl-L-proline lactaM

L-Leucyl-L-prolyl lactaM

Maculosin 6

(3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)-

Cyclo(-L-Leu-L-Pro)≥ 99% (TLC)

3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Cyclo(L-prolyl-L-leucyl)

c(Leu-Pro)

2873-36-1