ChemicalBook > CAS DataBase List > 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine

2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine

Product Name
2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
CAS No.
7139-02-8
Chemical Name
2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
Synonyms
Einecs 230-437-4;Dipyridamole EP G;Dipyridamole Impurity 7;Dipyridamole Impurity 7（Dipyridamole EP Impurity G）;2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine;2,6-dichloro-4,8-dipiperidinyl-pyrimido[5,4-d]pyrimidine;PyriMido[5,4-d]pyriMidine,2,6-dichloro-4,8-di-1-piperidinyl-;2,6-dichloro-4,8-bis(1-piperidinyl)pyrimido[5,4-d]pyrimidine;2,6-Dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine;2,6-Dichloro-4,8-di-(piperidin-l-yl)pyrimido[5,4-d] pyrimidine
CBNumber
CB41453863
Molecular Formula
C16H20Cl2N6
Formula Weight
367.28
MOL File
7139-02-8.mol
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2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Property

Melting point:
249-251℃
Boiling point:
504.1±50.0 °C(Predicted)
Density 
1.386±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly)
form 
Solid
pka
2.00±0.30(Predicted)
color 
Pale Yellow to Light Yellow
InChI
InChI=1S/C16H20Cl2N6/c17-15-20-12-11(13(21-15)23-7-3-1-4-8-23)19-16(18)22-14(12)24-9-5-2-6-10-24/h1-10H2
InChIKey
PCVJQTVUJJJSRQ-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(N2CCCCC2)=C2N=C(Cl)N=C(N3CCCCC3)C2=N1
LogP
2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D434265
Product name
2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Packaging
250mg
Price
$95
Updated
2021/12/16
TRC
Product number
D434265
Product name
2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Packaging
5g
Price
$475
Updated
2021/12/16
TRC
Product number
D434265
Product name
2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Packaging
25g
Price
$970
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
69386
Product name
2,6-Dichloro-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Packaging
5G
Price
$975
Updated
2021/12/16
Matrix Scientific
Product number
096083
Product name
2,6-Dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine
Purity
95+%
Packaging
250mg
Price
$1134
Updated
2021/12/16
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2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

An antitumor nucleoside pyrimido pyrimidine.

Synthesis

110-89-4

32980-71-5

7139-02-8

General procedure for the synthesis of 2,6-dichloro-4,8-dipiperidinosubstituted pyrimido[5,4-d]pyrimidines from hexahydropyridine and perchloropyrimido[5,4-d]pyrimidines: perchloropyrimido[5,4-d]pyrimidines (13.1 g, 48.9 mmol), piperidines, CuI (0.28 g, 1.5 mmol) and Cs2CO3 (16.0 g, 48.9 mmol) were added to a 250mL two-necked flask. 100 mL of nitrobenzene was added as reaction solvent and the reaction was carried out at 180°C for 16 h under nitrogen protection. After completion of the reaction, the nitrobenzene solvent was removed by distillation under reduced pressure. Purification by column chromatography using a solvent mixture of petroleum ether (PE) and dichloromethane (DCM) (6:1, v/v) gave 17.0 g of solid product in 95.0% yield and 99% selectivity.

References

[1] Patent: CN106946887, 2017, A. Location in patent: Paragraph 0035; 0036; 0037
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 20, p. 4905 - 4922
[3] Medicinal Chemistry Research, 1996, vol. 6, # 1, p. 61 - 67
[4] Journal of Medicinal Chemistry, 2007, vol. 50, # 16, p. 3906 - 3920
[5] Patent: CN108069972, 2018, A. Location in patent: Paragraph 0005; 0017

2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

5-AMINOOROTIC ACID Phosphorus oxitrichloride Urea 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine

Preparation Products

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2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine Suppliers

Canada 1 China 97 France 1 India 5 United Kingdom 1 United States 6 Global 111
Carbosynth
Tel
--
Fax
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Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
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View Lastest Price from 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine 7139-02-8
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Career Henan Chemical Co
Product
2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine 7139-02-8
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-21

7139-02-8, 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidineRelated Search:

Dipyridamole Mono-O-b-D-glucuronide 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Dipyridamole 2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol Piperidinylpiperidine 2,2',2'',2'''-[[4-[(2-Hydroxyethyl)aMino]-8-(1-piperidinyl)pyriMido[5,4-d]pyriMidine-2,6-diyl]dinitrilo]tetrakisethanol (DipyridaMole IMpurity) 4,8-dichloro-2,6-dipiperidinopyrimido[5,4-d]pyrimidine Dipyridamole Tripiperidine 6-Des(diethanolamino)-6-chloro Dipyridamole Dipyridamole Tri(diethanolamine) Desethanol Dipyridamole 2-CHLORO-4-PIPERIDIN-1-YL-PYRIMIDINE 2,6-Dichloro-4,8-(dipiperidino-D20)-pyrimido[5,4-d]pyrimidine 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine

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  • 2,6-DICHLORO-4,8-DI-1-PIPERIDINYLPYRIMIDO[5,4-D]PYRIMIDINEDIPYRIDAMOLE
  • Einecs 230-437-4
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  • 2,6-dichloro-4,8-dipiperidinyl-pyrimido[5,4-d]pyrimidine
  • 2,6-Dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine
  • 2,6-dichloro-4,8-bis(1-piperidinyl)pyrimido[5,4-d]pyrimidine
  • Dipyridamole Impurity 7（Dipyridamole EP Impurity G）
  • Dipyridamole EP Impurity GQ: What is Dipyridamole EP Impurity G Q: What is the CAS Number of Dipyridamole EP Impurity G Q: What is the storage condition of Dipyridamole EP Impurity G Q: What are the applications of Dipyridamole EP Impurity G
  • 2,6-Dichloro-4,8-di-(piperidin-l-yl)pyrimido[5,4-d] pyrimidine
  • 2,6-dichloro-4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine (DCDPP)
  • Dipyridamole Impurity 7
  • 2,6-Dichloro-4,8-Dipiperidinyl-Pyrimido[5,4-D]Pyrimidine(Dipyridamole Intermediate)
  • Dipyridamole EP G
  • 7139-02-8
  • 1913545
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