Methyl 5-formyl-2-methoxybenzoate

Product Name: Methyl 5-formyl-2-methoxybenzoate
CAS No.: 78515-16-9
Chemical Name: Methyl 5-formyl-2-methoxybenzoate
Synonyms: EOS-61914;Methoxy ester;Eluxadoline int4;Eluxadoline Intermediate 3;5-formyl-2-methoxybenzamide;methyl5-formyl-2-methoxybenzoate;4-Methoxy-3-methoxycarbonylbenzaldehyde;5-Formyl-2-methoxybenzoic Acid Methyl Ester;5-Formyl-2-methoxyl-benzoic acid methyl ester;Eluxadoline: Methyl 5-formyl-2-methoxybenzoate
CBNumber: CB41456990
Molecular Formula: C10H10O4
Formula Weight: 194.18
MOL File: 78515-16-9.mol

More

Less

Methyl 5-formyl-2-methoxybenzoate Property

Melting point:: 86-87 °C
Boiling point:: 163-165 °C(Press: 1 Torr)
Density: 1.191±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid
InChI: InChI=1S/C10H10O4/c1-13-9-4-3-7(6-11)5-8(9)10(12)14-2/h3-6H,1-2H3
InChIKey: CNRMXICSYWVJRD-UHFFFAOYSA-N
SMILES: C(OC)(=O)C1=CC(C=O)=CC=C1OC

More

Less

Safety

HS Code: 2918999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: M3327
Product name: Methyl 5-Formyl-2-methoxybenzoate
Purity: min. 98.0 %
Packaging: 5G
Price: $99
Updated: 2025/07/31

TCI Chemical

Product number: M3327
Product name: Methyl 5-Formyl-2-methoxybenzoate
Purity: min. 98.0 %
Packaging: 25G
Price: $297
Updated: 2025/07/31

Usbiological

Product number: 455719
Product name: Methyl 5-Formyl-2-methoxybenzoate
Packaging: 1g
Price: $333
Updated: 2021/12/16

TRC

Product number: M305410
Product name: Methyl5-Formyl-2-methoxybenzoate
Packaging: 50g
Price: $715
Updated: 2021/12/16

ChemScene

Product number: CS-M3114
Product name: Benzoicacid,5-formyl-2-methoxy-,methylester
Purity: 99.85%
Packaging: 10g
Price: $50
Updated: 2021/12/16

More

Less

Methyl 5-formyl-2-methoxybenzoate Chemical Properties,Usage,Production

Chemical Properties

White to Almost white powder to crystaline; Melting Point 87 °C.

Uses

Methyl 5-Formyl-2-methoxybenzoate is an intermediate used to synthesize peroxisome proliferator-activated receptor (PPAR) activators. It is also used to prepare 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene derivatives as PTP1B inhibitors.

Synthesis

616-76-2

74-88-4

78515-16-9

General procedure for the synthesis of methyl 5-formyl-2-methoxybenzoate from 5-formyl-2-hydroxybenzoic acid and iodomethane: 5-formyl-2-hydroxybenzoic acid (2.0 g, 12.0 mmol), iodomethane (1.5 mL, 25 mmol) and potassium carbonate (3.06 g, 22.2 mmol) were mixed in dimethylformamide (15 mL). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was dissolved in ethyl acetate, washed sequentially with water (2×), saturated saline (2×) and the organic phase was dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated under reduced pressure and the resulting residue was purified by column chromatography to afford the target product methyl 5-formyl-2-methoxybenzoate 1.85 g (79% yield). The structure of the product was confirmed by 1H-NMR (CDCl3, 500 MHz) and mass spectrometry: 1H-NMR δ 9.91 (s, 1H), 8.31 (d, J = 2.1 Hz, 1H), 8.02 (dd, J = 8.5, 2.5 Hz, 1H), 7.11 (d, J = 8.6 Hz, 1H), 3.99 (s, 3H), 3.91 (s, 3H); mass spectrometry: 195 (s, 3H); mass spectrometry: 196 (s, 3H); mass spectrometry: 196 (s, 3H). 3H); MS: 195.05 (MH)+.

References

[1] Patent: US2007/249607, 2007, A1. Location in patent: Page/Page column 65; 67; 69
[2] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 2, p. 313 - 316
[3] European Journal of Medicinal Chemistry, 2004, vol. 39, # 7, p. 573 - 578
[4] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 114
[5] Patent: WO2014/202528, 2014, A1. Location in patent: Page/Page column 108; 109

Methyl 5-formyl-2-methoxybenzoate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methyl 5-formyl-2-methoxybenzoate Suppliers

China 160 Europe 1 Germany 1 India 7 Japan 1 United States 11 Global 181

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-86818997 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2966
Advantage: 60

Syncozymes (Shanghai) Co.,Ltd.

Tel: 021-68187180 13681683526
Fax: 021-68187179
Email: lchen@syncozymes.com
Country: China
ProdList: 317
Advantage: 55

Beijing Bosennuokang Pharmaceutical Technology Co., Ltd.

Tel: 010-86203349 18201082367
Email: bosennuokang@163.com
Country: China
ProdList: 224
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
Fax: 0573-85285100
Email: isenchem@163.com
Country: China
ProdList: 9310
Advantage: 66

Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
Country: China
ProdList: 882
Advantage: 52

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

More

Less

View Lastest Price from Methyl 5-formyl-2-methoxybenzoate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Methyl 5-formyl-2-methoxybenzoate 78515-16-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl 5-formyl-2-methoxybenzoate 78515-16-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl 5-formyl-2-methoxybenzoate 78515-16-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

78515-16-9, Methyl 5-formyl-2-methoxybenzoateRelated Search:

Basic Violet 1 4-Methoxybenzoic acid Acetonitrile Methyl 4-(bromomethyl)benzoate Kresoxim-methyl Methyl 2-bromobenzoate Methanol Methyl benzoate Paraquat dichloride Methylparaben Methyl 4-methylbenzoate 2-Methoxybenzoic acid Methyl methoxyacetate Methyl 4-cyanobenzoate Methyl acrylate Methyl acetate methyl 5-formyl-2-nitrobenzoate Methyl

methyl5-formyl-2-methoxybenzoate

Benzoic acid, 5-formyl-2-methoxy-, methyl ester

5-formyl-2-methoxybenzamide

EOS-61914

Eluxadoline Intermediate 3

Methoxy ester

Eluxadoline: Methyl 5-formyl-2-methoxybenzoate

Eluxadoline int4

5-Formyl-2-methoxyl-benzoic acid methyl ester

4-Methoxy-3-methoxycarbonylbenzaldehyde

5-Formyl-2-methoxybenzoic Acid Methyl Ester

78515-16-9

API intermediates

Acids and Derivatives

Carbonyl Compounds