ChemicalBook > CAS DataBase List > 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE

8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE

Application

Product Name: 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
CAS No.: 933190-51-3
Chemical Name: 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
Synonyms: 8-broMo-6-chloroiMidazo[1;8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE;IMidazo[1,2-b]pyridazine, 8-broMo-6-chloro-;8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE ISO 9001：2015 REACH
CBNumber: CB41479957
Molecular Formula: C6H3BrClN3
Formula Weight: 232.47
MOL File: 933190-51-3.mol

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8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE Property

Density: 2.03±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 0.73±0.30(Predicted)
Appearance: Light yellow to brown Solid
InChI: InChI=1S/C6H3BrClN3/c7-4-3-5(8)10-11-2-1-9-6(4)11/h1-3H
InChIKey: LZEJQXOCRMRVNP-UHFFFAOYSA-N
SMILES: C12=NC=CN1N=C(Cl)C=C2Br

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B699745
Product name: 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139418
Product name: 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
Packaging: 10g
Price: $511
Updated: 2021/12/16

Matrix Scientific

Product number: 070349
Product name: 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
Purity: 95%
Packaging: 1g
Price: $908
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139418
Product name: 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
Packaging: 25g
Price: $1021
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044857
Product name: 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
Purity: 95.00%
Packaging: 1G
Price: $1575.42
Updated: 2021/12/16

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8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE Chemical Properties,Usage,Production

Application

8-Bromo-6-chloroimidazole[1,2-B]pyridazine is a pyridazine organic compound that can be used as a pharmaceutical intermediate.

Synthesis

446273-59-2

621-62-5

933190-51-3

3-Amino-4-bromo-6-chloropyridazine (15.7 g, 75.3 mmol) and chloroacetaldehyde diethyl acetal (13.9 g, 90.3 mmol) were reacted in isopropanol (150 mL) in the presence of p-toluenesulfonic acid (PTSA, 17.2 g, 90.3 mmol). The reaction mixture was heated to 80 °C and maintained at this temperature for 20 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was neutralized with saturated sodium bicarbonate solution (300 mL) and then extracted with dichloromethane (200 mL × 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (200-300 mesh, petroleum ether:ethyl acetate = 3:1) to afford the target product, 8-bromo-6-chloroimidazo[1,2-b]pyridazine (17.2 g, 98% yield), as an orange solid.LC-MS analysis showed [M + H]+ m/z 231.9, 233.9, and retention time tR = 1.46 min.

References

[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10414 - 10423
[2] Patent: US2013/109661, 2013, A1. Location in patent: Paragraph 0227-0228
[3] Patent: WO2013/64445, 2013, A1. Location in patent: Page/Page column 51

8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 8-Bromo-6-chloro-imidazo[1,2-b]pyridazine 933190-51-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-04-29

Shanghai Rlavie Technology Co ltd

Product: 8-Bromo-6-chloroimidazo[1,2-b]pyridazine 933190-51-3
Price: US $0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 50kgs/month
Release date: 2021-11-13

Dideu Industries Group Limited

Product: 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE 933190-51-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-02

933190-51-3, 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINERelated Search:

Imidazo[1,2-b]pyridazine 6-Chloroimidazo[2,1-f]pyridazine

8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE

IMidazo[1,2-b]pyridazine, 8-broMo-6-chloro-

8-broMo-6-chloroiMidazo[1

8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE ISO 9001：2015 REACH

933190-51-3