6-Chloroimidazo[2,1-f]pyridazine
Physical State Uses Safe handling- Product Name
- 6-Chloroimidazo[2,1-f]pyridazine
- CAS No.
- 6775-78-6
- Chemical Name
- 6-Chloroimidazo[2,1-f]pyridazine
- Synonyms
- 6-chloroimidazo[1,2-b]pyr...;6-Chloroimidazo[2,1-b]pyridazine;6-сhloroimidazo[1,2-b]pyridazine;6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE;6-Chloroimidazo[2,1-f]pyridazine;IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-;6-Chloroimidazo[1,2-b]pyridazine 98%;6-Chloroimidazo[2,1-f]pyridazine ISO 9001：2015 REACH;High purity CAS 6775-78-6 6-Chloroimidazo[2,1-f]pyridazine in stock
- CBNumber
- CB7187061
- Molecular Formula
- C6H4ClN3
- Formula Weight
- 153.57
- MOL File
- 6775-78-6.mol
6-Chloroimidazo[2,1-f]pyridazine Property
- Melting point:
- 114.0 to 118.0 °C
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 3.68±0.30(Predicted)
- color
- White to Gray to Brown
- InChI
- InChI=1S/C6H4ClN3/c7-5-1-2-6-8-3-4-10(6)9-5/h1-4H
- InChIKey
- MPZDNIJHHXRTIQ-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1N=C(Cl)C=C2
- CAS DataBase Reference
- 6775-78-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C3127
- Product name
- 6-Chloroimidazo[1,2-b]pyridazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- C3127
- Product name
- 6-Chloroimidazo[1,2-b]pyridazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $69
- Updated
- 2025/07/31
- Product number
- B419033
- Product name
- 6-Chloroimidazo[1,2-b]pyridazine
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A831
- Product name
- 6-Chloroimidazo[2,1-f]pyridazine
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- A831
- Product name
- 6-Chloroimidazo[2,1-f]pyridazine
- Packaging
- 5g
- Price
- $15
- Updated
- 2021/12/16
6-Chloroimidazo[2,1-f]pyridazine Chemical Properties,Usage,Production
Physical State
White to Gray to Brown powder to crystal
Uses
6-chloroimidazo[1,2-b]pyridazine (cas# 6775-78-6) is a useful research chemical.
Safe handling
Handling is performed in a well ventilated place.Wear suitable protective equipment.Prevent dispersion of dust.Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Avoid contact with skin,eyes and clothing.
Synthesis
5469-69-2
2032-35-1
6775-78-6
General procedure for the preparation of 6-chloroimidazo[1,2-b]pyridazine: Bromoacetaldehyde diethyl acetal (13.7 g, 69.5 mmol, 1.8 eq.) was added to hydrobromic acid (4.0 mL) and heated to reflux for 1.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into an isopropanol reaction flask containing an excess of sodium bicarbonate. After stirring for 3 minutes, filtration was performed. To the filtrate was added 3-amino-6-chloropyridazine (5.0 g, 38.6 mmol, 1.0 eq.) and the reflux was continued by heating for 2 hours. At the end of the reaction, the reaction mixture was quenched with water and extracted with ethyl acetate. Finally, the product was purified by column chromatography to give 5.1 g of brown solid in 86% yield. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.89 (s, 1H), 7.88 (d, J = 9.3 Hz, 1H), 7.74 (s, 1H), 7.01 (d, J = 9.3 Hz, 1H).
References
[1] Patent: US2014/256733, 2014, A1. Location in patent: Paragraph 0227-0229
[2] Patent: WO2012/69202, 2012, A1. Location in patent: Page/Page column 46
[3] Patent: EP2463289, 2012, A1. Location in patent: Page/Page column 17-18
[4] Patent: EP2818471, 2014, A1. Location in patent: Paragraph 0117; 0118
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2789 - 2798
6-Chloroimidazo[2,1-f]pyridazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloroimidazo[2,1-f]pyridazine manufacturers
- Product
- 6-Chloroimidazo[1,2-b]pyridazine 6775-78-6
- Price
- US $6.00-80.00/g
- Min. Order
- 5g
- Purity
- 0.98
- Supply Ability
- 25kg
- Release date
- 2023-12-08
- Product
- 6-Chloroimidazo[1,2-b]pyridazine 6775-78-6
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-02
- Product
- 6-Chloroimidazo[2,1-f]pyridazine 6775-78-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 100kgs/month
- Release date
- 2021-11-05