ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE

Product Name: ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE
CAS No.: 64067-99-8
Chemical Name: ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE
Synonyms: Ethyl 6-Chloroimidazo[1,2-b]pyridazine-2-;ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYATE;ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE;Ethyl 6-Chloroimidazo[1,2-β]pyridazine-2-carboxylate;ethyl 6-chloroimidazo[2,1-f][1,2]diazine-2-carboxylate;methyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate ;6-Chloroimidazo[1,2-β]pyridazine-2-carboxylic Acid Ethyl Ester;6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid Ethyl Ester;ethyl 6-chloro-1,5-dihydroiMidazo[1,2-b]pyridazine-2-carboxylate;Imidazo[1,2-b]pyridazine-2-carboxylic acid, 6-chloro-, ethyl ester
CBNumber: CB9266900
Molecular Formula: C9H8ClN3O2
Formula Weight: 225.63
MOL File: 64067-99-8.mol

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ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Property

Melting point:: 155-158
Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
form: Solid
pka: 0.17±0.30(Predicted)
color: Brown
InChI: InChI=1S/C9H8ClN3O2/c1-2-15-9(14)6-5-13-8(11-6)4-3-7(10)12-13/h3-5H,2H2,1H3
InChIKey: AZEPEWATPYRPBM-UHFFFAOYSA-N
SMILES: C12=NC(C(OCC)=O)=CN1N=C(Cl)C=C2

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: E901920
Product name: Ethyl6-Chloroimidazo[1,2-b]pyridazine-2-carboxylate
Packaging: 500mg
Price: $75
Updated: 2021/12/16

Usbiological

Product number: 011574
Product name: Ethyl 6-Chloroimidazo[1,2-b]pyridazine-2-carboxylate
Packaging: 1g
Price: $425
Updated: 2021/12/16

TRC

Product number: E901920
Product name: Ethyl6-Chloroimidazo[1,2-b]pyridazine-2-carboxylate
Packaging: 5g
Price: $570
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0026089
Product name: ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 250MG
Price: $647.36
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0026089
Product name: ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $699.74
Updated: 2021/12/16

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ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

Brown Solid

Uses

Anti-inflammatory agent.

Synthesis

5469-69-2

70-23-5

64067-99-8

To a suspension of 6-chloropyridazin-3-amine (10.00 g, 77 mmol) in ethanol (30 mL) at 0 °C, a solution of ethyl 3-bromo-2-oxopropanoate (20.07 g, 93 mmol) in ethanol (5 mL) was slowly added by pipette. After addition, the ice bath was removed and the reaction mixture was stirred at room temperature for 15 min, followed by warming to 80 °C for 30 min. After 2 hours of reaction, the mixture was cooled to room temperature and the precipitated beige solid was collected by vacuum filtration and washed with cold ethanol. The resulting solid was suspended in saturated aqueous NaHCO3 solution and stirred for 30 minutes. The solid was again collected by vacuum filtration and the filter cake was washed with water, dried over a filter and further dried under vacuum to give ethyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate as a brown solid (8.8 g, 39.0 mmol, 51% yield). The product was characterized by NMR (400 MHz, chloroform-d3): δ 8.46 (s, 1H), 8.13 (d, J=9.5 Hz, 1H), 7.23 (d, J=9.5 Hz, 1H), 4.49 (q, J=7.2 Hz, 2H), 1.46 (t, J=7.1 Hz, 3H). the LC retention time was 2.29 min (Analytical HPLC method A). LC/MS showed (M+H)+ peaks of 226/228 (ratio about 3:1).

References

[1] Patent: WO2016/149437, 2016, A1. Location in patent: Page/Page column 58
[2] Journal of Pharmacology and Experimental Therapeutics, 2018, vol. 364, # 2, p. 246 - 257
[3] Patent: WO2016/97347, 2016, A1. Location in patent: Page/Page column 149
[4] Patent: WO2016/97359, 2016, A1. Location in patent: Page/Page column 125
[5] Farmaco, 1997, vol. 52, # 4, p. 213 - 217

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Suppliers

Belgium 1 Canada 1 China 118 Germany 3 India 1 The Netherlands 1 United Kingdom 2 United States 22 Global 149

Shanghai ZhengXia Medical Technology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Energy Chemical

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Capot Chemical Co., Ltd

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Shangchem Co., Ltd.

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Chemsky（shanghai）International Co.,Ltd.

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Shanghai Ennopharm Co., Ltd.

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skychemical Co.Ltd

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View Lastest Price from ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE manufacturers

Shanghai Rlavie Technology Co ltd

Product: 6-Chloroimidazo[1,2-b]pyridazine-2-carboxylicacid ethyl ester 64067-99-8
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 98%minHPLC
Supply Ability: 50kgs/month
Release date: 2021-11-14

Dideu Industries Group Limited

Product: ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE 64067-99-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-11-02

Career Henan Chemical Co

Product: ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE 64067-99-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-19

64067-99-8, ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATERelated Search:

6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID, METHYL ESTER 6-Chloroimidazo[2,1-f]pyridazine (6-CHLOROIMIDAZO[1,2-B]PYRIDAZIN-3-YL)(PHENYL)METHANONE 6-chloroiMidazo[1,2-b]pyridazine-3-carboxylic acid 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-3-CARBONITRILE 6-Chloro-2-hydroxyimidazo[1,2-b]pyridazine 6-Chloropicolinic acid 6-Chloronicotinic acid tert-butyl ester Imidazo[1,2-b]pyridazine IMIDAZO[1,2-B]PYRIDAZINE, 6-CHLORO-2-METHYL- 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLIC ACID ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE Imidazo[1,2-b]pyridazine-2-carboxylic acid Imidazo[1,2-b]pyridazine, methanone deriv 2-METHYL-1H-IMIDAZOL-1-AMINE 6-CHLORO-IMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXALDEHYDE 2-Methylimidazo[1,2-b]pyridazine

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE

Ethyl 6-Chloroimidazo[1,2-b]pyridazine-2-

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYATE

6-Chloroimidazo[1,2-β]pyridazine-2-carboxylic Acid Ethyl Ester

Ethyl 6-Chloroimidazo[1,2-β]pyridazine-2-carboxylate

methyl 6-chloroimidazo[1,2-b]pyridazine-2-carboxylate

6-Chloroimidazo[1,2-b]pyridazine-2-carboxylic Acid Ethyl Ester

ethyl 6-chloro-1,5-dihydroiMidazo[1,2-b]pyridazine-2-carboxylate

Imidazo[1,2-b]pyridazine-2-carboxylic acid, 6-chloro-, ethyl ester

ETHYL 6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE-2-CARBOXYLATE ISO 9001：2015 REACH

ethyl 6-chloroimidazo[2,1-f][1,2]diazine-2-carboxylate

64067-99-8

Bases & Related Reagents

Heterocycles

Intermediates

Nucleotides

Heterocyclic Compounds

blocks

Carboxes

Imidazoles

Pyridines