6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester
- Product Name
- 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester
- CAS No.
- 1150566-27-0
- Chemical Name
- 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester
- Synonyms
- Ethyl 6-chloroiMidazo[1,2...;6-chloroimidazo[1,2-a]pyrazine-3-carboxylic acid;ethyl 6-chloroiMidazo[1,2-b]pyridazne-3-carboxylate;6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester;Imidazo[1,2-b]pyridazine-3-carboxylic acid, 6-chloro-, ethyl ester
- CBNumber
- CB42574471
- Molecular Formula
- C9H8ClN3O2
- Formula Weight
- 225.63
- MOL File
- 1150566-27-0.mol
6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 0.88±0.30(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2928009090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B124860
- Product name
- Ethyl6-Chloroimidazo[1,2-b]pyridazine-3-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR927013
- Product name
- Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H58-5-93
- Product name
- Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- OR927013
- Product name
- Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate
- Packaging
- 5g
- Price
- $173
- Updated
- 2021/12/16
- Product number
- 4H58-5-93
- Product name
- Ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate
- Packaging
- 5G
- Price
- $205
- Updated
- 2021/12/16
6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Uses
6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester is mainly used as pharmaceutical intermediates.
Synthesis
1150566-26-9
1150566-27-0
General procedure for the synthesis of ethyl 6-chloroimidazo[1,2-B]pyridazine-3-carboxylate from the compound (CAS:1150566-26-9): S-chloro-β-dimethylamino-methyleneamino-J-isoethyloxycarbonylmethyl-pyridazine-1-bromide (11.40 g, 32.40 mmol) was dissolved in acetonitrile (200 mL), followed by addition of diisopropylethylamine (15.22 mL, 64.81 mmol). The reaction mixture was stirred at room temperature for 4 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was ground with water to afford 5.77 g of ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate as a light brown solid in 77% yield. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 8.36 (1H, s), 8.01 (1H, d, J = 9.4 Hz), 7.27 (1H, d, J = 9.4 Hz), 4.46 (2H, q, J = 7.1 Hz), 1.37 (3H, t, J = 7.1 Hz).LCMS analysis showed m/z 226 [M + 1]+ (molecular weight: 225.64).
References
[1] Patent: WO2009/60197, 2009, A1. Location in patent: Page/Page column 59
[2] Patent: US2012/65184, 2012, A1. Location in patent: Page/Page column 37
6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester manufacturers
- Product
- ethyl 6-chloroimidazo[1,2-b]pyridazine-3-carboxylate 1150566-27-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-13
- Product
- 6-Chloro-iMidazo[1,2-b]pyridazine-3-carboxylic acid ethyl ester 1150566-27-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-02