8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
Application- Product Name
- 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
- CAS No.
- 933190-51-3
- Chemical Name
- 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
- Synonyms
- 8-broMo-6-chloroiMidazo[1;8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE;IMidazo[1,2-b]pyridazine, 8-broMo-6-chloro-;8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE ISO 9001：2015 REACH
- CBNumber
- CB41479957
- Molecular Formula
- C6H3BrClN3
- Formula Weight
- 232.47
- MOL File
- 933190-51-3.mol
8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE Property
- Density
- 2.03±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 0.73±0.30(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C6H3BrClN3/c7-4-3-5(8)10-11-2-1-9-6(4)11/h1-3H
- InChIKey
- LZEJQXOCRMRVNP-UHFFFAOYSA-N
- SMILES
- C12=NC=CN1N=C(Cl)C=C2Br
N-Bromosuccinimide Price
- Product number
- B699745
- Product name
- 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB139418
- Product name
- 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Packaging
- 10g
- Price
- $511
- Updated
- 2021/12/16
- Product number
- 070349
- Product name
- 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Purity
- 95%
- Packaging
- 1g
- Price
- $908
- Updated
- 2021/12/16
- Product number
- FB139418
- Product name
- 8-Bromo-6-chloroimidazo[1,2-b]pyridazine
- Packaging
- 25g
- Price
- $1021
- Updated
- 2021/12/16
- Product number
- HCH0044857
- Product name
- 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1575.42
- Updated
- 2021/12/16
8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE Chemical Properties,Usage,Production
Application
8-Bromo-6-chloroimidazole[1,2-B]pyridazine is a pyridazine organic compound that can be used as a pharmaceutical intermediate.
Synthesis
446273-59-2
621-62-5
933190-51-3
3-Amino-4-bromo-6-chloropyridazine (15.7 g, 75.3 mmol) and chloroacetaldehyde diethyl acetal (13.9 g, 90.3 mmol) were reacted in isopropanol (150 mL) in the presence of p-toluenesulfonic acid (PTSA, 17.2 g, 90.3 mmol). The reaction mixture was heated to 80 °C and maintained at this temperature for 20 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure to remove the solvent. The concentrated residue was neutralized with saturated sodium bicarbonate solution (300 mL) and then extracted with dichloromethane (200 mL × 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (200-300 mesh, petroleum ether:ethyl acetate = 3:1) to afford the target product, 8-bromo-6-chloroimidazo[1,2-b]pyridazine (17.2 g, 98% yield), as an orange solid.LC-MS analysis showed [M + H]+ m/z 231.9, 233.9, and retention time tR = 1.46 min.
References
[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 23, p. 10414 - 10423
[2] Patent: US2013/109661, 2013, A1. Location in patent: Paragraph 0227-0228
[3] Patent: WO2013/64445, 2013, A1. Location in patent: Page/Page column 51
8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE Suppliers
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- Country
- Germany
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View Lastest Price from 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE manufacturers
- Product
- 8-Bromo-6-chloro-imidazo[1,2-b]pyridazine 933190-51-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-04-29
- Product
- 8-Bromo-6-chloroimidazo[1,2-b]pyridazine 933190-51-3
- Price
- US $0.00/KG
- Min. Order
- 1g
- Purity
- 98%minHPLC
- Supply Ability
- 50kgs/month
- Release date
- 2021-11-13
- Product
- 8-BROMO-6-CHLOROIMIDAZO[1,2-B]PYRIDAZINE 933190-51-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02