ChemicalBook > CAS DataBase List > 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE

1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE

Product Name
1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE
CAS No.
101258-16-6
Chemical Name
1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE
Synonyms
1-(2-amino-4-thiazolyl)ethanone;Ketone 2-amino-4-thiazolyl methyl;Ethanone,1-(2-aMino-4-thiazolyl)-
CBNumber
CB41491018
Molecular Formula
C5H6N2OS
Formula Weight
142.18
MOL File
101258-16-6.mol
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1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE Property

Melting point:
230 °C
Boiling point:
303.1±15.0 °C(Predicted)
Density 
1.341±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.41±0.10(Predicted)
Appearance
Light yellow to khaki Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A630175
Product name
1-(2-Aminothiazol-4-yl)ethanone
Packaging
25mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
X8554
Product name
1-(2-Aminothiazol-4-yl)ethanone
Packaging
100mg
Price
$104
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA131170
Product name
1-(2-Amino-1,3-thiazol-4-yl)ethanone
Packaging
1g
Price
$255
Updated
2021/12/16
Matrix Scientific
Product number
075915
Product name
1-(2-Aminothiazol-4-yl)ethanone
Purity
95+%
Packaging
250mg
Price
$370
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA131170
Product name
1-(2-Amino-1,3-thiazol-4-yl)ethanone
Packaging
500mg
Price
$150
Updated
2021/12/16
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1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE Chemical Properties,Usage,Production

Uses

1-(2-Aminothiazol-4-yl)ethanone is a versatile reactant, used as intermediate in preparation of multicyclic sulfonamide compounds as histone deacetylase inhibitors useful in treatment and prevention of diseases.

Synthesis

762271-84-1

101258-16-6

General procedure for the synthesis of 2-aminothiazole-4-ethanone from tert-butyl (4-acetylthiazol-2-yl)carbamate: Trifluoroacetic acid (5 mL) was added to the chloroform solution (10 mL) of the above-prepared acetyl compound, and the reaction was stirred at room temperature for 1.5 hours. After completion of the reaction, the reaction solution was concentrated, neutralized to neutral with saturated aqueous sodium bicarbonate solution, and the solid was collected by filtration to afford 2-aminothiazole-4-acetophenone 149 mg (yield: 59%) as a white solid. The product was characterized by 1H-NMR (CDCl3): δ 2.48 (3H, s), 7.35 (1H, s); ESI-MS (m/e): 143 [M + H]+.

References

[1] Patent: EP1598349, 2005, A1. Location in patent: Page/Page column 127

1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE manufacturers

Career Henan Chemical Co
Product
1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE 101258-16-6
Price
US $1.00/KG
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-10

101258-16-6, 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONERelated Search:

Ethyl 2-(2-aminothiazol-4-yl)glyoxylate 2-(2-Aminothiazol-4-yl)glyoxylic acid 2-AMINO-5-(BROMOTHIAZOL-4-YL)OXOACETIC ACID METHYL ESTER 2-AMINO-6,6-DIMETHYL-6,7-DIHYDRO-5H-BENZOTHIAZOL-4-ONE 1-(5-METHYL-2-[3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]-1,3-THIAZOL-4-YL)-1-ETHANONE SALOR-INT L149802-1EA 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE CHEMBRDG-BB 9072017 ETHYL 2-(2-[(4-CHLOROBENZOYL)AMINO]-1,3-THIAZOL-4-YL)-2-OXOACETATE 2-METHOXYCARBONYLAMINO-4-METHYLSULFANYL-BUTYRIC ACID, 4-(4,9-DIOXO-4,9-DIHYDRONAPHTHO[2,3-D]THIAZOL-2-YLAMINO)-PHENYL ESTER

  • Ethanone,1-(2-aMino-4-thiazolyl)-
  • 1-(2-amino-4-thiazolyl)ethanone
  • Ketone 2-amino-4-thiazolyl methyl
  • 101258-16-6