1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE
- Product Name
- 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE
- CAS No.
- 101258-16-6
- Chemical Name
- 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE
- Synonyms
- 1-(2-amino-4-thiazolyl)ethanone;Ketone 2-amino-4-thiazolyl methyl;Ethanone,1-(2-aMino-4-thiazolyl)-
- CBNumber
- CB41491018
- Molecular Formula
- C5H6N2OS
- Formula Weight
- 142.18
- MOL File
- 101258-16-6.mol
1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE Property
- Melting point:
- 230 °C
- Boiling point:
- 303.1±15.0 °C(Predicted)
- Density
- 1.341±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.41±0.10(Predicted)
- Appearance
- Light yellow to khaki Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A630175
- Product name
- 1-(2-Aminothiazol-4-yl)ethanone
- Packaging
- 25mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- X8554
- Product name
- 1-(2-Aminothiazol-4-yl)ethanone
- Packaging
- 100mg
- Price
- $104
- Updated
- 2021/12/16
- Product number
- FA131170
- Product name
- 1-(2-Amino-1,3-thiazol-4-yl)ethanone
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FA131170
- Product name
- 1-(2-Amino-1,3-thiazol-4-yl)ethanone
- Packaging
- 1g
- Price
- $255
- Updated
- 2021/12/16
- Product number
- 075915
- Product name
- 1-(2-Aminothiazol-4-yl)ethanone
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $370
- Updated
- 2021/12/16
1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE Chemical Properties,Usage,Production
Uses
1-(2-Aminothiazol-4-yl)ethanone is a versatile reactant, used as intermediate in preparation of multicyclic sulfonamide compounds as histone deacetylase inhibitors useful in treatment and prevention of diseases.
Synthesis
762271-84-1
101258-16-6
General procedure for the synthesis of 2-aminothiazole-4-ethanone from tert-butyl (4-acetylthiazol-2-yl)carbamate: Trifluoroacetic acid (5 mL) was added to the chloroform solution (10 mL) of the above-prepared acetyl compound, and the reaction was stirred at room temperature for 1.5 hours. After completion of the reaction, the reaction solution was concentrated, neutralized to neutral with saturated aqueous sodium bicarbonate solution, and the solid was collected by filtration to afford 2-aminothiazole-4-acetophenone 149 mg (yield: 59%) as a white solid. The product was characterized by 1H-NMR (CDCl3): δ 2.48 (3H, s), 7.35 (1H, s); ESI-MS (m/e): 143 [M + H]+.
References
[1] Patent: EP1598349, 2005, A1. Location in patent: Page/Page column 127
1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE Suppliers
- Tel
- --
- Fax
- --
- enamine@enamine.net
- Country
- Ukraine
- ProdList
- 6216
- Advantage
- 67
View Lastest Price from 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE manufacturers
- Product
- 1-(2-AMINO-1,3-THIAZOL-4-YL)ETHANONE 101258-16-6
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10