6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER
- Product Name
- 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER
- CAS No.
- 360576-01-8
- Chemical Name
- 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER
- Synonyms
- 6-bromo-benzo[b]thiophene-2-carboxyL;Methyl 6-BroMobenzo[b]thiophene-2-carboxy;Methyl 6-Bromobenzothiophene-2-carboxylate;Piperazine,1-(3-chlorophenyl)-,hydrochloride(1:4);6-BroMobenzothiophene-2-carboxylic Acid Methyl Ester;6-BroMo-1-benzothiophene-2-carboxylic Acid Methyl Ester;Benzo[b]thiophene-2-carboxylic acid, 6-bromo-, methyl ester;Methyl 6-bromo-1-benzothiophene-2-carboxylate, 6-Bromo-2-(methoxycarbonyl)benzo[b]thiophene
- CBNumber
- CB41501762
- Molecular Formula
- C10H7BrO2S
- Formula Weight
- 271.13
- MOL File
- 360576-01-8.mol
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Property
- Melting point:
- 117-119°
- Boiling point:
- 358.9±22.0 °C(Predicted)
- Density
- 1.622±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- powder
- color
- Off-white
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- B680265
- Product name
- 6-Bromobenzothiophene-2-carboxylicAcidMethylEster
- Packaging
- 5g
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 004638
- Product name
- 6-Bromobenzothiophene-2-carboxylic Acid Methyl Ester
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- 6H66-9-Y0
- Product name
- Methyl 6-bromobenzo[b]thiophene-2-carboxylate
- Packaging
- 1g
- Price
- $42
- Updated
- 2021/12/16
- Product number
- 047910
- Product name
- Methyl 6-bromo-1-benzothiophene-2-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 047910
- Product name
- Methyl 6-bromo-1-benzothiophene-2-carboxylate
- Purity
- >95%
- Packaging
- 5g
- Price
- $319
- Updated
- 2021/12/16
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
6-Bromobenzo[b]thiophene-2-carboxylic acid methyl ester is used in the synthesis of benzothiophene derivatives as histone deacetylase inhibitors.
Synthesis
2365-48-2
57848-46-1
360576-01-8
GENERAL METHOD: Compound 1a or 1b (9.90 mmol) was dissolved in DMF (20 mL) under stirring conditions, followed by the sequential addition of methyl mercaptoacetate (10.9 mmol) and potassium carbonate (39.6 mmol). The reaction mixture was stirred continuously at 60 °C for 15 hours. After completion of the reaction, the DMF solvent was removed by distillation under reduced pressure. Water (50 mL) was added to the residue, which was then extracted with ethyl acetate (2 x 40 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and the solvent was removed by reduced pressure distillation to give the final target product, methyl 6-bromobenzo[b]thiophene-2-carboxylate (2a or 2b).
References
[1] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 538 - 550
[2] Patent: WO2012/149413, 2012, A1. Location in patent: Page/Page column 58
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 1, p. 264 - 281
[4] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[5] Patent: JP2015/89879, 2015, A. Location in patent: Paragraph 0016; 0047; 0048
6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER manufacturers
- Product
- 6-BROMO-BENZO[B]THIOPHENE-2-CARBOXY LIC ACID METHYL ESTER 360576-01-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02