3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER

Uses

Product Name: 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER
CAS No.: 34529-06-1
Chemical Name: 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER
Synonyms: MFCD16293748;Apster Impurity 75.;dimethyl 3-aminophthalate;Sitagliptin Impurity 37-d3;dimethyl 3-aminobenzene-1,2-dioate;3-Amino-phthalic acid dimethyl ester;dimethyl 3-aminobenzene-1,2-dicarboxylate;3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER;DiMethyl 3-aMino-1,2-benzenedicarboxylate;Methyl 3-amino-2-(methoxycarbonyl)benzoate
CBNumber: CB41502628
Molecular Formula: C10H11NO4
Formula Weight: 209.2
MOL File: 34529-06-1.mol

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3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER Property

Boiling point:: 306℃
Density: 1.248
Flash point:: 136℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.05±0.10(Predicted)
Appearance: Off-white to yellow Solid-Liquid Mixture

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Safety

HS Code: 2921420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: D492838
Product name: Dimethyl3-Aminophthalate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 112863
Product name: Dimethyl 3-amino-1,2-benzenedicarboxylate
Packaging: 1g
Price: $44
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-8R
Product name: Dimethyl 3-amino-1,2-benzenedicarboxylate
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD133109
Product name: Dimethyl 3-aminophthalate hydrochloride
Packaging: 250mg
Price: $85
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-8R
Product name: Dimethyl 3-amino-1,2-benzenedicarboxylate
Packaging: 5G
Price: $125
Updated: 2021/12/16

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3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER Chemical Properties,Usage,Production

Uses

Dimethyl 3-aminophthalate is a useful research chemical.

Synthesis

13365-26-9

34529-06-1

The general procedure for the synthesis of dimethyl 3-amino-phthalate from methyl 3-nitrophthalate was as follows: first, methyl 3-nitrophthalate was converted to the corresponding chloride by a chlorination reaction, followed by esterification to obtain dimethyl 3-nitrophthalate (100% yield). Next, the nitro group was reduced to an amino group by catalytic hydrogenation to obtain dimethyl 3-amino-phthalate (100% yield). Subsequently, diazotization of the amino group was followed by iodination to obtain dimethyl 3-iodophthalate (about 91% yield). Then, a saponification reaction was carried out on dimethyl 3-iodophthalate, followed by acidification to obtain 3-iodophthalic acid (yield about 93%). Finally, 3-iodophthalic acid was oxidized and reacted in the presence of KBrO3 and 0.73 M H2SO4 at 55-60 °C for 12 h to obtain water-soluble MIBX.Upon completion of the reaction, purification by evaporation, cooled milling and filtration yielded white solid MIBX (~70% yield, melting point 258-260 °C). The conversion of the process is nearly quantitative and can be monitored by 1H NMR spectroscopy.The physical properties of MIBX include IR (KBr) showing characteristic absorption peaks; 1H NMR (D2O, 300 MHz) and 13C NMR (D2O, 75 MHz) showing specific chemical shifts.

References

[1] Journal of Heterocyclic Chemistry, 1989, vol. 26, # 6, p. 1885 - 1886
[2] Tetrahedron Letters, 2002, vol. 43, # 4, p. 569 - 572
[3] Patent: US2004/30187, 2004, A1. Location in patent: Page 2; Sheet 1
[4] RSC Advances, 2015, vol. 5, # 60, p. 48861 - 48867
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 1, p. 285 - 288

3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER Suppliers

China 71 France 1 India 2 United Kingdom 3 United States 12 Global 89

Alchem Pharmtech,Inc.

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View Lastest Price from 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER manufacturers

Asia Chem I and E (Jiangsu) Co Ltd

Product: Dimethyl 3-aminophthalate 34529-06-1
Price: US $139.50/Kg/Drum
Min. Order: 25Kg/Drum
Purity: 98.00%HPLC
Supply Ability: 5tons/month
Release date: 2021-09-18

Career Henan Chemical Co

Product: 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER 34529-06-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-03

34529-06-1, 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTERRelated Search:

Dioctyl terephthalate Benzoyl chloride Phthalic acid 4-Aminophthalic acid 3-AMINOPHTHALIC ACID HYDROCHLORIDE 3-AMINOPHTHALIC ACID AKOS 243-18 AKOS 227-89 DIMETHYL 3-NITROPHTHALATE METHYL-3-N-ACETYLAMINO PHTHALATE AKOS 227-94 3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER

3-AMINO-1,2-PHTHALIC ACID, DIMETHYL ESTER

3-Amino-phthalic acid dimethyl ester

3-aminobenzene-1,2-dicarboxylic acid dimethyl ester

3-Amino-1,2-benzenedicarboxylic acid 1,2-dimethyl ester

dimethyl 3-aminophthalate

Methyl 3-amino-2-(methoxycarbonyl)benzoate

1,2-diMethyl 3-aMinobenzene-1,2-dicarboxylate

1,2-Benzenedicarboxylicacid, 3-aMino-, 1,2-diMethyl ester

DiMethyl 3-aMino-1,2-benzenedicarboxylate

MFCD16293748

dimethyl 3-aminobenzene-1,2-dicarboxylate

dimethyl 3-aminobenzene-1,2-dioate

1,2-Dimethyl 3-amino-1,2-benzenedicarboxylate

methyl 6-amino-2-(methoxycarbonyl)benzoate

Apster Impurity 75.

Sitagliptin Impurity 37-d3

34529-06-1