4-(Methylaminomethyl)benzonitrile
- Product Name
- 4-(Methylaminomethyl)benzonitrile
- CAS No.
- 34403-48-0
- Chemical Name
- 4-(Methylaminomethyl)benzonitrile
- Synonyms
- methyl-4-cyanobenzylamine;N-Methyl-4-cyanobenzylaMine;4-(Methylaminomethyl)benzonitrile;Benzonitrile, 4-[(methylamino)methyl]-
- CBNumber
- CB41509142
- Molecular Formula
- C9H10N2
- Formula Weight
- 146.19
- MOL File
- 34403-48-0.mol
4-(Methylaminomethyl)benzonitrile Property
- Melting point:
- 108-109 °C
- Boiling point:
- 148-151 °C(Press: 14 Torr)
- Density
- 1.04±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 9.01±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M328695
- Product name
- 4-(Methylaminomethyl)benzonitrile
- Packaging
- 1g
- Price
- $175
- Updated
- 2021/12/16
- Product number
- V5324
- Product name
- 4-(Methylaminomethyl)benzonitrile
- Packaging
- 5g
- Price
- $392
- Updated
- 2021/12/16
- Product number
- 081802
- Product name
- 4-[(Methylamino)methyl]benzonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $433
- Updated
- 2021/12/16
- Product number
- CHM0119161
- Product name
- 4-[(METHYLAMINO)METHYL]BENZONITRILE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
- Product number
- A103994
- Product name
- 4-((Methylamino)methyl)benzonitrile
- Purity
- 95%
- Packaging
- 25g
- Price
- $675
- Updated
- 2021/12/16
4-(Methylaminomethyl)benzonitrile Chemical Properties,Usage,Production
Chemical Properties
Colorless Liquid
Synthesis
17201-43-3
74-89-5
34403-48-0
GENERAL STEPS: Methylamine (350 mL, 40% aqueous, 4.06 mol) was slowly added to a solution of 4-(bromomethyl)benzonitrile (51.3 g, 262 mmol) in ethanol (500 mL) and the reaction was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. To the residue, dichloromethane (500 mL) and saturated aqueous sodium bicarbonate (400 mL) were added, mixed thoroughly and left to partition. The organic phase was separated and washed with saturated aqueous sodium chloride solution (250 mL) and subsequently dried over anhydrous sodium sulfate. After filtering to remove the desiccant, the organic phase was concentrated under reduced pressure. The resulting residue was dissolved in a solution of 1 M hydrochloric acid in ether (300 mL), stirred for 30 minutes, filtered and the solid was washed with ether. The solid was dissolved in water (500 mL) and the pH was adjusted to alkaline with 6 M aqueous sodium hydroxide, followed by extraction with dichloromethane (500 mL). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and the solvent was concentrated under reduced pressure to afford the target product N-methyl-4-cyanobenzylamine. Yield: 31.17 g, 81% yield.
References
[1] Patent: US2008/153843, 2008, A1. Location in patent: Page/Page column 88
[2] Patent: WO2012/101453, 2012, A1. Location in patent: Page/Page column 41
[3] Journal of Medicinal Chemistry, 1983, vol. 26, # 3, p. 309 - 312
[4] Journal of Medicinal Chemistry, 1986, vol. 29, # 1, p. 40 - 44
[5] Journal of Medicinal Chemistry, 1998, vol. 41, # 15, p. 2882 - 2891
4-(Methylaminomethyl)benzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(Methylaminomethyl)benzonitrile manufacturers
- Product
- 4-(Methylaminomethyl)benzonitrile 34403-48-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09