PUROMYCIN DIHYDROCHLORIDE

Product Name: PUROMYCIN DIHYDROCHLORIDE
CAS No.: 58-58-2
Chemical Name: PUROMYCIN DIHYDROCHLORIDE
Synonyms: pdh;PUROMYCIN;PUROMYCIN 2HCL;l-2hc;abs9143;Purinomycin;-9H-purin-9-yl);Puromycin dihydrochL;P638 dihydrochloride;-5-(6-(dimethylamino)
CBNumber: CB4152905
Molecular Formula: C22H30ClN7O5
Formula Weight: 507.98
MOL File: 58-58-2.mol

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PUROMYCIN DIHYDROCHLORIDE Property

Melting point:: 168-170℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: H2O: soluble50mg/mL (Sterilize stock solution by filtration using 0.22 μm filter then store in aliquots at 20 °C.)
form: solution
color: yellow-white
Water Solubility: Soluble in water
Merck: 14,7943
BRN: 3853613
Stability:: Stable. Heat sensitive. Incompatible with strong oxidizing agents.
InChIKey: MKSVFGKWZLUTTO-NGOAXYITSA-N
EPA Substance Registry System: Adenosine, 3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-, dihydrochloride (58-58-2)

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Safety

Hazard Codes: Xn
Risk Statements: 22-40
Safety Statements: 24/25
RIDADR: 3249
WGK Germany: 3
RTECS: AU7355000
F: 3-8-10
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29419090
Toxicity: LD50 oral in guinea pig: 600mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P7255
Product name: Puromycin dihydrochloride from Streptomyces alboniger
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $86.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: P7255
Product name: Puromycin dihydrochloride from Streptomyces alboniger
Purity: ≥98% (HPLC), powder
Packaging: 1g
Price: $1980
Updated: 2024/03/01

Sigma-Aldrich

Product number: 540411
Product name: Puromycin, Dihydrochloride, Cell Culture-Tested - CAS 58-58-2 - Calbiochem
Purity: Puromycin, CAS 58-58-2, is a protein synthesis inhibitor that causes premature release of nascent polypeptide chains.
Packaging: 25MG
Price: $92.2
Updated: 2022/05/15

Sigma-Aldrich

Product number: 540411
Product name: Puromycin, Dihydrochloride, Cell Culture-Tested - CAS 58-58-2 - Calbiochem
Purity: Puromycin, CAS 58-58-2, is a protein synthesis inhibitor that causes premature release of nascent polypeptide chains.
Packaging: 100MG
Price: $280
Updated: 2022/05/15

Sigma-Aldrich

Product number: 540222
Product name: Puromycin, Dihydrochloride - CAS 58-58-2 - Calbiochem
Packaging: 25MG
Price: $78.9
Updated: 2022/05/15

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PUROMYCIN DIHYDROCHLORIDE Chemical Properties,Usage,Production

Description

Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3

Chemical Properties

white powder

Uses

Puromycin is an aminonucleoside antibitotic. Puromycin acts as a protein synthesis inhibitor which interferes with translation by inhibiting ribosome functions. Puromycin is also a reversible inhibitor of dipeptidyl-peptidase II (serine peptidase) and cytosol alanyl aminopeptidase.

Uses

antibacterial

Uses

Puromycin dihydrochloride is the salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

Uses

Puromycin dihydrochloride is a salt of puromycin, a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypansomal agent with antibiotic activity. While the salt shares the same pharmacological properties as puromycin free base, its greater water solubility offers advantages in some in vitro applications. Physicochemical properties and chromatographic behaviour will depend on whether the pH is buffered. In non-pH controlled systems, the free base and salt may behave differently.

Uses

An aminonuclease antibiotic used for selection and maintenance of cell lines expressing a transfected pac gene.

Uses

Research tool for studying protein synthesis; cell line selection agent in gene transfer experiments.

General Description

White powder.

Air & Water Reactions

Water soluble.

Reactivity Profile

PUROMYCIN DIHYDROCHLORIDE is sensitive to prolonged exposure to heat. . Behaves as a very weak acid in solution.

Fire Hazard

Flash point data for PUROMYCIN DIHYDROCHLORIDE are not available, but PUROMYCIN DIHYDROCHLORIDE is probably combustible.

storage

-20°C

Purification Methods

Puromycin dihydrochloride is purified by recrystallisation from H2O. The free base, [58-60-6] M 294.3, has m 175.5-177o (172-173o) (from H2O). The sulfate has m 180-187o dec (from H2O), and the picrate monohydrate has m 146-149o (from H2O). [Baker et al. J Am Chem Soc 77 1 1955, Fryth et al. J Am Chem Soc 80 3736 1958.] It is an inhibitor of aminopeptidase and terminates protein synthesis [Reboud et al. Biochemistry 20 5281 1981]. [Beilstein 26 III/IV 3704.]

References

1) Azzam and Algranati; (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes; Proc. Nat. Acad. Sci. USA, 70 3866 2) Bhutani et al. (2007) Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences by proteasomes during protein degradation; EMBO J., 26 1385 3) Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction; Biochim. Biophys. Acta, 1150 89

PUROMYCIN DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PUROMYCIN DIHYDROCHLORIDE Suppliers

Australia 2 Belgium 1 Canada 3 China 220 Europe 2 France 2 Germany 8 India 9 Poland 1 Switzerland 2 United Kingdom 15 United States 28 Global 293

BioAustralis

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View Lastest Price from PUROMYCIN DIHYDROCHLORIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: PUROMYCIN DIHYDROCHLORIDE 58-58-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: PUROMYCIN DIHYDROCHLORIDE 58-58-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: Puromycin dihydrochloride hydrate 58-58-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-26

58-58-2, PUROMYCIN DIHYDROCHLORIDERelated Search:

PUROMYCIN(RG),PUROMYCIN (S)-TETRAHYDROFURAN-3-AMINE HYDROCHLORIDE (S)-3-AMINOTETRAHYDROFURAN TETRAHYDRO-FURAN-3-YLAMINE HCL PUROMYCIN DIHYDROCHLORIDE Adenine hydrochloride hemihydrate Adenine hydrochloride Adenine Sulfate N-(3-Aminopropyl)-imidazole 6-Dimethylaminopurine PUROMYCIN DIHYDROCHLORIDE,PUROMYCIN 2HCL,PUROMYCIN DIHYDROCHLORIDE,PUROMYCIN 3'-Amino-2',3'-dideoxyadenosine PUROMYCIN AMINONUCLEOSIDE,Puromycin Aminonucleoside, 6-Dimethylamin-9-[3-amino-3deoxyribosyl]-purine Cyclopenthiazide 3-N-PROPYL-TETRAHYDROFURAN-3-YL-AMINE HYDROCHLORIDE 3'-AMINO-D-ADENOSINE H-TYR-NH2 HCL 3-(IMIDAZOLE-1-YL)-PROPYLAMINE DIHYDROCHLORIDE

Puromycin dihydrochloride hydrate,99%

3’-(alpha-amino-p-methoxyhydrocinnamamido)-3’-deoxy-n,n-dimethyl-adenosin

adenosine,3’-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3’-deoxy-n,n-dim

dihydrochloride,(s)-ethyl

PUROMYCIN Dihydrochloride Dihydrate 96%

3'-[[12-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL

3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE

3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYL-ADENOSINE 2HCL

3'-(A-AMINO-P-METHOXYHYDROCINNAMAMIDO)-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE

3'-(A-AMINO-P-METHOXY-HYDOCINNAMAMIDO)-3'-DEXOY-N,N-DIMETHYLADENOSINE 2HCL

3'-(ALPHA-AMINO-P-METHOXY-HYDROCINNAMINO-3'-DEOXY-N,N-DIMETHY-ADENOSINE) 2HCL

3'-(ALPHA-AMINO-P-METHOXY-HYDROCINNAMIDO-3'-DEOXY-N,N-DIMETHYL-ADENOSINE) 2HCL

3'-[ALPHA-AMINO-P-METHOXYHYDROCINNAMAMIDO]-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE

3'-(ALPHA-AMINO-P-METHOXYHYDROCINNAMAMIDO)-3'-DEOXY-N,N-DIMETHYLADENOSINE, 2HCL

3'-(ALPHA-AMINO-P-METHOXYHYDROCINNAMADIO)-3'-DEOXY-N,N-DIMETHYLADENOSINE DIHYDROCHLORIDE

PUROMYCIN, CELL CULTURE TESTED

Puromycin, 3-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3-deoxy-N,N-dimethyladenosine dihydrochloride

Puromycin hydrate dihydrochloride

DIHYDROGEN PUROMYCIN DICHLORIDE

Puromycin dihydrochL

CL 13900 dihydrochloride

P638 dihydrochloride

STYLOMYCIN HYDROCHLORIDE; CL 13900 DIHYDROCHLORIDE; CL16536; NSC 3055; P638 DIHYDROCHLORIDE

PuroMycin dihydrochloride hydrate, 99% 10MG

PuroMycin dihydrochlorid

Puromycin dihydrochloride (animal free)

StyloMycin dihydrochloride, CL 13900 dihydrochloride, CL16536, NSC 3055, P638 dihydrochloride.

3'-[[(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine,hydrochloride (1:2)

Puromycin 2HCl (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

Puromycin dihydrochloride (S)-3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

Puromycin 2hydrochloride

-2-Amino-N-((2S,3S,4R,5R)

-4-hydroxy-2-(hydroxymethyl)

-5-(6-(dimethylamino)

-9H-purin-9-yl)

propanamide dihydrochloride

tetrahydrofuran-3-yl)

PUROMYCIN DIHYDROCHLORIDE

PUROMYCIN 2HCL

PUROMYCIN

(S) 3'-[[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE 2HCL

(S)-3'-[2-AMINO-3-(4-METHOXYPHENYL)-1-OXOPROPYL]AMINO]-3'-DEOXY-N,N-DIMETHYLADENOSINE

l-2hc

pdh

puromycinhydrochloride

stylomycinhydrochloride

PUROMYCIN DIHYDROCHLORIDE CELL*CULTURE T ESTED

PUROMYCIN READY MADE SOLUTION

PUROMYCIN DIHYDROCHLORIDE FROM STREPTO-M YCES ALBO-NIGER

(S)-3'-[[2-amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

PUROMYCIN DIHYDROCHLORIDE CELL CULTURE REAGENT

PUROMYCIN DIHYDROCHLORIDE ULTRA PURE GRADE 98+%

Puromycin.Cellculturedtested

Puromycin,Solution,CellCultureTested

Adenosine, 3-(2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropylamino-3-deoxy-N,N-dimethyl-, dihydrochloride

3'-[α-amino-p-methoxyhydrocinnamamido]-3'-deoxy-n,n-dimethyladenosine dihydrochloride

PUROMYCINDIHYROCHLORIDE

PUROMYCIN DIHYDROCHLORIDE USP/EP/BP