ChemicalBook > CAS DataBase List > 4-Chlorobenzhydrylchloride

4-Chlorobenzhydrylchloride

Product Name: 4-Chlorobenzhydrylchloride
CAS No.: 134-83-8
Chemical Name: 4-Chlorobenzhydrylchloride
Synonyms: UNII:LC0K0NYJ2N;4-Chlorobenzhydrylch;LABOTEST-BB LT00160064;P-CHLOROBENZHYDRYL CHLORIDE;4-CHLOROBENZHYDRYL CHLORIDE;à,4-dichlorodiphenylmethane;?,4-dichloro-?-phenyltoluene;α,4-dichloro-α-phenyltoluene;4-Chlorodiphenylmethylchloride;Para Chlorobenzhydryl Chloride
CBNumber: CB4153609
Molecular Formula: C13H10Cl2
Formula Weight: 237.12
MOL File: 134-83-8.mol

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4-Chlorobenzhydrylchloride Property

Boiling point:: 159-160 °C2 mm Hg(lit.)
Density: 1.239 g/mL at 25 °C(lit.)
refractive index: n20/D 1.603(lit.)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form: clear liquid
color: Colorless to Light yellow to Light orange
Water Solubility: IMMISCIBLE
Sensitive: Moisture Sensitive
BRN: 2050236
CAS DataBase Reference: 134-83-8(CAS DataBase Reference)
NIST Chemistry Reference: Benzene, 1-chloro-4-(chlorophenylmethyl)-(134-83-8)
EPA Substance Registry System: Benzene, 1-chloro-4-(chlorophenylmethyl)- (134-83-8)

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Safety

Hazard Codes: C
Risk Statements: 34-36/37-36
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3265 8/PG 2
WGK Germany: 3
TSCA: Yes
HazardClass: 8
PackingGroup: II
HS Code: 29036990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H318Causes serious eye damage

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1234
Product name: 4-Chlorobenzhydryl Chloride
Packaging: 25G
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: C1234
Product name: 4-Chlorobenzhydryl Chloride
Packaging: 500G
Price: $312
Updated: 2025/07/31

TRC

Product number: C364855
Product name: 1-Chloro-4-(chlorophenylmethyl)benzene
Packaging: 25g
Price: $85
Updated: 2021/12/16

Apolloscientific

Product number: OR40704
Product name: 4-Chlorobenzhydryl Chloride
Packaging: 500g
Price: $138
Updated: 2021/12/16

SynQuest Laboratories

Product number: 1700-5-Z3
Product name: 4-Chlorobenzhydryl Chloride
Packaging: 500g
Price: $152
Updated: 2021/12/16

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4-Chlorobenzhydrylchloride Chemical Properties,Usage,Production

Chemical Properties

clear light yellow liquid

Uses

1-Chloro-4-(chlorophenylmethyl)benzene is used in the synthesis of novel benzhydrylpiperazine derivatives as cytotoxic compounds in the treatment of various cancers.

Preparation

Preparation of 4-Chlorobenzhydryl Chloride (4-CBC): The 4-chlorobenzhydrol (4-CB) in 15 mL of toluene, obtained from the previous step, was mixed with 10 mL of conc. HCl at 60oC maintained at the same temperature for 2.5 h. The reaction mixture was cooled to 20oC to separate into organic and aqueous layers. The toluene layer was washed with 10 % aq. sodium carbonate to pH 7, dried over anhydrous sodium sulphate and taken to next step without isolation.

Synthesis

119-56-2

134-83-8

GENERAL METHODS: NaBH4 (0.6 mol) was added batchwise to a stirred solution of benzophenone (1.0 mol) in methanol (2 vol) at room temperature for 45 min. The reaction mixture was stirred at ambient temperature for 2-3 h (progress of the reaction was monitored by TLC) and subsequently diluted with water (750 mL) and pH adjusted with acetic acid to 4. The reaction mixture was extracted with dichloromethane (2 x 400 mL). The organic layer was washed with water (200 mL), dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the pure diphenylmethanol derivative as a white to off-white solid in 93-97% yield. To a stirred solution of diphenylmethanol derivative (1.0 mol) in toluene (370 mL) at room temperature was sequentially added concentrated HCl (35% aqueous solution, 370 mL) and tetrabutylammonium bromide (0.01 mol). The reaction mixture was stirred at 40-45 °C for 6-7 hours. After confirming the completion of the reaction by TLC, the mixture was cooled to room temperature. The organic layer was separated and concentrated under vacuum to afford the crude diphenylmethyl chloride derivative as a light brown liquid in 95-97% yield. Anhydrous piperazine (5.0 mol) was slowly added to a solution of diphenylmethyl chloride derivative (0.96 mol) in toluene (380 mL) at 60-70 °C for 45-60 minutes. The resulting mixture was heated with stirring at 90-100°C for 8-10 hours. After completion of the reaction, the mixture was cooled and water (380 mL) was added to separate the organic layer. The organic layer was washed with a mixture of concentrated HCl and water (1:1, 2 x 350 mL) and neutralized with 20% NaOH solution (750 mL). The aqueous layer was again extracted with toluene (2 × 300 mL), and the combined organic layers were dried with anhydrous sodium sulfate and concentrated in vacuum to afford the pure diphenylmethylpiperazine compounds (2a-c) as white to off-white solids in 88% yield.

References

[1] Australian Journal of Chemistry, 2006, vol. 59, # 7, p. 445 - 456
[2] Journal of the American Chemical Society, 1928, vol. 50, p. 1804
[3] Journal of the American Chemical Society, 1928, vol. 50, p. 1804
[4] Synthesis, 1976, p. 326 - 329
[5] Journal of Medicinal and Pharmaceutical Chemistry, 1962, vol. 5, p. 1008 - 1015

4-Chlorobenzhydrylchloride Preparation Products And Raw materials

Raw materials

Toluene 4-Chlorobenzhydrol Ethyl acetate Magnesium sulfate Thionyl chloride PETROLEUM ETHER

Preparation Products

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View Lastest Price from 4-Chlorobenzhydrylchloride manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-Chlorobenzhydrylchloride 134-83-8
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-26

Career Henan Chemical Co

Product: 4-Chlorobenzhydrylchloride 134-83-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-99.9%
Supply Ability: 100kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 4-Chlorobenzhydrylchloride 134-83-8
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

134-83-8, 4-ChlorobenzhydrylchlorideRelated Search:

4,4'-Methylenedianiline Triphenylmethyl Chloride Chloromethane Chlorodiphenylmethane Diphenylmethane 3,4'-DIAMINODIPHENYLMETHANE Benzene Chlorofluoromethane 1,1-BIS(4-CHLOROPHENYL)-1,2,2,2-TETRACHLOROETHANE Benzyl chloride Diphenyldichloromethane 3,11-Dichloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepine 5,5-dioxide Difluorochloromethane 4,4'-(ALPHA,4-DICHLOROBENZYLIDENE)BIS[2,2'-(PHENYLIMINO)DIETHANOL] 1,1'-(chloromethylene)bis[4-chlorobenzene] dichloro[(dichlorophenyl)methyl]methylbenzene 4-Chlorobenzhydrylchloride AKOS 94028

P-CHLOROBENZHYDRYL CHLORIDE

1-chloro-4-(chlorophenylmethyl)-benzen

Benzene,1-chloro-4-(chlorophenylmethyl)-

Benzene,1-chloro-4-(chlorophenylmethyl)-4-Chlorobenzhydrylchloride

Chloro[4-chlorophenyl]phenylmethone

Methane, chloro(p-chlorophenyl)phenyl-

4-CHLOROBENZHYDRYL CHLORIDE

4-CHLORO DIPHENYL METHANE CHLORIDE

4'-CHLORO-DIPHENYL CHLOROMETHANE

ALPHA,4-DICHLORODIPHENYLMETHANE

1-Chloro-4-(chlorophenylmethyl)-benzene

LABOTEST-BB LT00160064

CHLORO(4-CHLOROPHENYL)PHENYLMETHANE

CHLORO(P-CHLOROPHENYL) PHENYLMETHANE

alpha,4-dichloro-alpha-phenyltoluene

Chloro(4-chlorophenyl)phenylmethane 4-Chlorobenzhydryl Chloride

4-CHLOROBENZHYDRYL CHLORIDE 98%

4-Chloro Diphenyl Chloride Methane

4-Chlorobenzhydrylchloride, 99+%

à,4-dichlorodiphenylmethane

4-Chlorobenzhydryl chloride, 98+%

α-(4-Chlorophenyl)benzyl chloride

AVO 4- Chlorobenzhydryl Chloride

4-Chlorobenzhydrylch

4-Chlorobenzhydryl Chloride &gt

4-Chlorobenzhydrylchloride ISO 9001：2015 REACH

?,4-dichloro-?-phenyltoluene

4-Pair Diphenyl methyl chloride

4-Chlorodiphenylmethylchloride

Para Chlorobenzhydryl Chloride

4- Chloro Benzhydryl Chloride (Intermediate of Cetirizine )

UNII:LC0K0NYJ2N

α,4-dichloro-α-phenyltoluene

134-83-8

134-83-3

ClC6H4CHC6H5Cl

C13H10Cl2

BENZYL HALIDE

C13 to C37+

Aryl

Building Blocks

Halogenated Hydrocarbons

Organic Building Blocks