ChemicalBook > CAS DataBase List > 2-Fluorophenylboronic acid
2-Fluorophenylboronic acid
- Product Name
- 2-Fluorophenylboronic acid
- CAS No.
- 1993-03-9
- Chemical Name
- 2-Fluorophenylboronic acid
- Synonyms
- 2-Fluorophenylboronic;2-Flurorphenylboronic acid;2-FLUOROBENZENEBORONIC ACID;AKOS BRN-0104;2-fluoroborate;RARECHEM AH PB 0215;2-Fluorophenylboroni;o-Fluorphenylborsaeure;uorobenzeneboronic acid;Vonoprazan Impurity 215
- CBNumber
- CB4153982
- Molecular Formula
- C6H6BFO2
- Formula Weight
- 139.92
- MOL File
- 1993-03-9.mol
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2-Fluorophenylboronic acid Property
- Melting point:
- 101-110 °C (lit.)
- Boiling point:
- 267.8±42.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- pka
- 8.32±0.58(Predicted)
- form
- Crystalline Powder
- color
- White to light yellow
- BRN
- 3030413
- InChI
- InChI=1S/C6H6BFO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H
- InChIKey
- QCSLIRFWJPOENV-UHFFFAOYSA-N
- SMILES
- B(C1=CC=CC=C1F)(O)O
- CAS DataBase Reference
- 1993-03-9(CAS DataBase Reference)
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Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-22
- Safety Statements
- 37/39-26-36/37/39-27-24/25
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29319090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 445223
- Product name
- 2-Fluorophenylboronic acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $68.8
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 445223
- Product name
- 2-Fluorophenylboronic acid
- Purity
- ≥95%
- Packaging
- 10g
- Price
- $491.75
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0407
- Product name
- 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $25
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0407
- Product name
- 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $72
- Updated
- 2025/07/31
TCI Chemical
- Product number
- F0407
- Product name
- 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $213
- Updated
- 2025/07/31
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2-Fluorophenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystalline powder
Uses
suzuki reaction
Uses
2-Fluorophenylboronic Acid, is used in Rh-catalyzed enantioselective addition reactions, and Rhodium and Palladium-catalyzed substitution reactions. It can also be used in the preparation of phenylboronic catechol esters as promising anion receptors for polymer electrolytes.
Uses
Used for the preparation of biologically active biphenyls and arylboron difluoride Lewis acids.
Synthesis
1072-85-1
1993-03-9
The general procedure for the synthesis of 2-fluorophenylboronic acid from o-bromofluorobenzene was as follows: 10.0 g (57.1 mmol) of 1-bromo-2-fluorobenzene and anhydrous tetrahydrofuran were added to a reaction flask and the mixture was subsequently cooled to -70 °C. At -70 °C, 44.2 ml (68.5 mmol) of 1.55 M n-butyllithium solution was slowly added dropwise to the reaction mixture. The temperature was maintained at -70 °C and stirring of the reaction mixture was continued for 1.5 hours. Subsequently, 21.5 g (114.2 mmol) of triisopropyl borate was added dropwise and the reaction temperature was gradually raised to room temperature and stirring was continued for 4 hours. Upon completion of the reaction, aqueous hydrochloric acid was added to the reaction mixture and extracted with dichloromethane. The organic phases were combined and the solvent was removed by distillation under reduced pressure to give the crude product of 2-fluorophenylboronic acid. The crude product was purified by column chromatography (eluent: hexane/acetone) to give 4.8 g (yield: 61%) of pure 2-fluorophenylboronic acid.
References
[1] Patent: US2012/273770, 2012, A1. Location in patent: Page/Page column 24
[2] Patent: US2004/6076, 2004, A1. Location in patent: Page 15
[3] Journal of Organic Chemistry, 2013, vol. 78, # 13, p. 6427 - 6439
2-Fluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluorophenylboronic acid manufacturers
Hebei Jingbo New Material Technology Co., Ltd
- Product
- 2-Fluorophenylboronic acid 1993-03-9
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 200000
- Release date
- 2023-12-27
Henan Fengda Chemical Co., Ltd
- Product
- 2-Fluorophenylboronic acid 1993-03-9
- Price
- US $30.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-26
Xinxiang Hongqi District Houyuan Trading Co.,Ltd
- Product
- 2-Fluorophenylboronic acid 1993-03-9
- Price
- US $30.00-150.00/Kg
- Min. Order
- 100Kg
- Purity
- 99.0% up
- Supply Ability
- 50 tons per month
- Release date
- 2022-10-07
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