2-Fluoropyridine-4-boronic acid
- Product Name
- 2-Fluoropyridine-4-boronic acid
- CAS No.
- 401815-98-3
- Chemical Name
- 2-Fluoropyridine-4-boronic acid
- Synonyms
- CAS:401815-98-3;uoropyridin-4-yL;4-Borono-2-fluoropyridine;2-FLUOROPYRIDINE-BORONIC ACID;2-Fluoropyridine-4-boronicaci;2-Fluoro-4-pyridylboronic acid;2-fluoro-4-pyridine boric acid;2-FLUORO-4-PYRIDINEBORONIC ACID;2-FLUOROPYRIDINE-4-BORONIC ACID;2-FLUORO-4-PYRIDINYLBORONIC ACID
- CBNumber
- CB0438900
- Molecular Formula
- C5H5BFNO2
- Formula Weight
- 140.91
- MOL File
- 401815-98-3.mol
2-Fluoropyridine-4-boronic acid Property
- Melting point:
- ca 195℃
- Boiling point:
- 326.8±52.0 °C(Predicted)
- Density
- 1.34±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 6.51±0.10(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 401815-98-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0935
- Product name
- 2-Fluoropyridine-4-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 1g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- F0935
- Product name
- 2-Fluoropyridine-4-boronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $315
- Updated
- 2025/07/31
- Product number
- F596190
- Product name
- 2-Fluoropyridine-4-boronicAcid
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 277966
- Product name
- 2-Fluoropyridine-4-boronic acid
- Packaging
- 500mg
- Price
- $347
- Updated
- 2021/12/16
- Product number
- F2370
- Product name
- 2-Fluoropyridine-4-boronicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
2-Fluoropyridine-4-boronic acid Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
2-Fluoropyridine-4-boronic Acid is used to synthesize analogues of the antitubercular drug.
Synthesis
5419-55-6
128071-98-7
401815-98-3
Step 1: 4-bromo-2-fluoropyridine (30.0 g, 0.17 mol) and triisopropyl borate (38.4 g, 0.20 mol) were dissolved in a solvent mixture of anhydrous toluene and tetrahydrofuran (THF) (4:1, 250 mL) under nitrogen protection. The reaction mixture was cooled to -78 °C, followed by slow dropwise addition of n-butyllithium (80 mL, 0.20 mol, 2.5 M hexane solution) over 30 min. After the dropwise addition was completed, stirring was continued at -78 °C for 30 min. The reaction mixture was then slowly warmed up to -20°C over 1 hr. The progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent: petroleum ether (PE):ethyl acetate (EtOAc) = 1:1) to confirm that the raw materials were completely consumed. Upon completion of the reaction, the mixture was acidified to pH 2 with 3N HCl (50 mL) and stirred at room temperature for 15 minutes. The reaction mixture was transferred to a partition funnel and extracted with EtOAc (150 mL) and water (150 mL). The organic layer was separated, washed sequentially with water and brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give (2-fluoropyridin-4-yl)boronic acid (22.0 g, 91% yield) as a white solid.
References
[1] Patent: WO2015/103137, 2015, A1. Location in patent: Paragraph 00178
[2] Patent: US7087755, 2006, B1. Location in patent: Page/Page column 6
[3] Patent: US2004/122237, 2004, A1. Location in patent: Page 201
2-Fluoropyridine-4-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoropyridine-4-boronic acid manufacturers
- Product
- 2-Fluoropyridine-4-boronic acid 401815-98-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- 2-Fluoropyridine-4-boronic acid 401815-98-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 2-Fluoropyridine-4-boronic acid 401815-98-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11