2-ACETAMIDO-5-NITROTHIAZOLE
- Product Name
- 2-ACETAMIDO-5-NITROTHIAZOLE
- CAS No.
- 140-40-9
- Chemical Name
- 2-ACETAMIDO-5-NITROTHIAZOLE
- Synonyms
- CL 5279;Gynofon;Nitasol;Nitazol;CL 5,279;Nitazole;Pleocide;Tricogen;Tricoral;Tritheon
- CBNumber
- CB4156271
- Molecular Formula
- C5H5N3O3S
- Formula Weight
- 187.18
- MOL File
- 140-40-9.mol
2-ACETAMIDO-5-NITROTHIAZOLE Property
- Melting point:
- 263°C (dec.)
- Boiling point:
- 421°
- Density
- 1.546 (estimate)
- refractive index
- 1.6560 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMF:3.0(Max Conc. mg/mL);16.03(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);53.43(Max Conc. mM) - form
- solid
- pka
- 8.78±0.50(Predicted)
- color
- White to Amber
- Merck
- 14,410
- BRN
- 167361
- InChI
- InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)
- InChIKey
- UJRRDDHEMZLWFI-UHFFFAOYSA-N
- SMILES
- C(NC1=NC=C([N+]([O-])=O)S1)(=O)C
- CAS DataBase Reference
- 140-40-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22
- Safety Statements
- 22-36/37-24/25
- RTECS
- XJ1570000
- HS Code
- 29341000
- Toxicity
- chicken,LD50,oral,800mg/kg (800mg/kg),Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H228Flammable solid
H301Toxic if swalloed
H302Harmful if swallowed
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P321Specific treatment (see … on this label).
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S540846
- Product name
- 2-ACETAMIDO-5-NITROTHIAZOLE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $185
- Updated
- 2025/07/31
- Product number
- S540846
- Product name
- 2-ACETAMIDO-5-NITROTHIAZOLE
- Purity
- Aldrich
- Packaging
- 250mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- A0689
- Product name
- 2-Acetamido-5-nitrothiazole
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- A0689
- Product name
- 2-Acetamido-5-nitrothiazole
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $191
- Updated
- 2025/07/31
- Product number
- 37558
- Product name
- 2-Acetamido-5-nitrothiazole,≥98%(Assaybytitration,HPLC)
- Purity
- ≥98%(Assaybytitration,HPLC)
- Packaging
- 5G
- Price
- $235.29
- Updated
- 2021/12/16
2-ACETAMIDO-5-NITROTHIAZOLE Chemical Properties,Usage,Production
Chemical Properties
Yellow-brown solid
Uses
antiinflammatory, glucocorticoid
Uses
Nithiamide is a drug for chemotherapy. A protistocide drug with antibacterial activity.
Definition
ChEBI: Aminitrozole is an aromatic amide and a member of acetamides.
Safety Profile
Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of SO, and NOx,.
Synthesis
121-66-4
108-24-7
140-40-9
General method: 2-amino-5-nitrothiazole (0.3 g, 2.0 mmol) was dissolved in dichloromethane, followed by the addition of 1.2 molar equivalents of triethylamine (TEA). The reaction mixture was stirred at 5 °C for 15 min, then acetic anhydride (10.0 mmol, 5 eq.) or the corresponding chloride (2.2 mmol, 1.1 eq.) was added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 4 to 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue is neutralized with saturated sodium bicarbonate (NaHCO3) solution and the resulting solid is purified by recrystallization from the appropriate solvent mixture.
Purification Methods
Recrystallise acinitrazole from EtOH or AcOH. [Hurd & Wehrmeister J Am Chem Soc 71 4007 1949, Beilstein 27 III/IV 4676.]
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 5, p. 1626 - 1633
2-ACETAMIDO-5-NITROTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
2-ACETAMIDO-5-NITROTHIAZOLE Suppliers
- Tel
- --
- Fax
- --
- sales@tcieurope.be
- Country
- Belgium
- ProdList
- 2200
- Advantage
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View Lastest Price from 2-ACETAMIDO-5-NITROTHIAZOLE manufacturers
- Product
- 2-ACETAMIDO-5-NITROTHIAZOLE 140-40-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-07-18
- Product
- Nithiamide 140-40-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Nithiamide 140-40-9
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08