ChemicalBook > CAS DataBase List > 2-ACETAMIDO-5-NITROTHIAZOLE

2-ACETAMIDO-5-NITROTHIAZOLE

Product Name
2-ACETAMIDO-5-NITROTHIAZOLE
CAS No.
140-40-9
Chemical Name
2-ACETAMIDO-5-NITROTHIAZOLE
Synonyms
CL 5279;Gynofon;Nitasol;Nitazol;CL 5,279;Nitazole;Pleocide;Tricogen;Tricoral;Tritheon
CBNumber
CB4156271
Molecular Formula
C5H5N3O3S
Formula Weight
187.18
MOL File
140-40-9.mol
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2-ACETAMIDO-5-NITROTHIAZOLE Property

Melting point:
263°C (dec.)
Boiling point:
421°
Density 
1.546 (estimate)
refractive index 
1.6560 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMF:3.0(Max Conc. mg/mL);16.03(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);53.43(Max Conc. mM)
form 
solid
pka
8.78±0.50(Predicted)
color 
White to Amber
Merck 
14,410
BRN 
167361
InChI
InChI=1S/C5H5N3O3S/c1-3(9)7-5-6-2-4(12-5)8(10)11/h2H,1H3,(H,6,7,9)
InChIKey
UJRRDDHEMZLWFI-UHFFFAOYSA-N
SMILES
C(NC1=NC=C([N+]([O-])=O)S1)(=O)C
CAS DataBase Reference
140-40-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-36/37-24/25
RTECS 
XJ1570000
HS Code 
29341000
Toxicity
chicken,LD50,oral,800mg/kg (800mg/kg),Antibiotics and Chemotherapy Vol. 5, Pg. 540, 1955.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H228Flammable solid

H301Toxic if swalloed

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P321Specific treatment (see … on this label).

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S540846
Product name
2-ACETAMIDO-5-NITROTHIAZOLE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$185
Updated
2025/07/31
Sigma-Aldrich
Product number
S540846
Product name
2-ACETAMIDO-5-NITROTHIAZOLE
Purity
Aldrich
Packaging
250mg
Price
$179
Updated
2024/03/01
TCI Chemical
Product number
A0689
Product name
2-Acetamido-5-nitrothiazole
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$75
Updated
2025/07/31
TCI Chemical
Product number
A0689
Product name
2-Acetamido-5-nitrothiazole
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$191
Updated
2025/07/31
ChemScene
Product number
CS-4486
Product name
Nithiamide
Purity
>98.0%
Packaging
100mg
Price
$72
Updated
2021/12/16
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2-ACETAMIDO-5-NITROTHIAZOLE Chemical Properties,Usage,Production

Chemical Properties

Yellow-brown solid

Uses

antiinflammatory, glucocorticoid

Uses

Nithiamide is a drug for chemotherapy. A protistocide drug with antibacterial activity.

Definition

ChEBI: Aminitrozole is an aromatic amide and a member of acetamides.

Safety Profile

Poison by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of SO, and NOx,.

Synthesis

121-66-4

108-24-7

140-40-9

General method: 2-amino-5-nitrothiazole (0.3 g, 2.0 mmol) was dissolved in dichloromethane, followed by the addition of 1.2 molar equivalents of triethylamine (TEA). The reaction mixture was stirred at 5 °C for 15 min, then acetic anhydride (10.0 mmol, 5 eq.) or the corresponding chloride (2.2 mmol, 1.1 eq.) was added slowly and dropwise. The reaction mixture was continued to be stirred at room temperature for 4 to 24 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue is neutralized with saturated sodium bicarbonate (NaHCO3) solution and the resulting solid is purified by recrystallization from the appropriate solvent mixture.

Purification Methods

Recrystallise acinitrazole from EtOH or AcOH. [Hurd & Wehrmeister J Am Chem Soc 71 4007 1949, Beilstein 27 III/IV 4676.]

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 5, p. 1626 - 1633

2-ACETAMIDO-5-NITROTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ACETAMIDO-5-NITROTHIAZOLE Suppliers

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View Lastest Price from 2-ACETAMIDO-5-NITROTHIAZOLE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-ACETAMIDO-5-NITROTHIAZOLE 140-40-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000KG
Release date
2024-07-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nithiamide 140-40-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Nithiamide 140-40-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

140-40-9, 2-ACETAMIDO-5-NITROTHIAZOLERelated Search:

5-NITRO-1,3-THIAZOLE 96 Dinitolmide 2-Acetamido-5-nitrothiazole VETRANAL 2-ACETAMIDO-5-NITROTHIAZOLE tenonitrozole Nitazoxanide 2-ACETAMIDOTHIAZOLE TIZOXANIDE 2-CHLORO-N-(5-NITRO-THIAZOL-2-YL)-ACETAMIDE TIZOXANIDE GLUCURONIDE, SODIUM SALT ACETAMIDO-5-NITROTHIAZOLE 2-ACETAMIDO-5-NITROTHIAZOLE 1G [R] N-(5-NITRO-1,3-THIAZOL-2-YL)-2-FURAMIDE 4-CHLORO-N-(5-NITRO-1,3-THIAZOL-2-YL)BENZENECARBOXAMIDE N-(5-NITRO-1,3-THIAZOL-2-YL)BENZENECARBOXAMIDE AURORA 22569 AURORA 22570 N-(3-NITRO(2,5-THIAZOLYL))(PHENYLCYCLOPENTYL)FORMAMIDE

  • AKOS AU36-M376
  • 2-ACETYLAMINO-5-NITROTHIAZOLE
  • 2-ACETAMINO-5-NITROTHIAZOLE
  • 2-ACETAMIDO-5-NITROTHIAZOLE
  • N-(5-NITRO-2-THIAZOLYL)ACETAMIDE
  • 2-acetamido-5-nitro-thiazol
  • 5-Nitro-2-acetamidothiazole
  • 5-Nitro-2-acetilaminotiazolo
  • Acetamide, N-(5-nitro-2-thiazolyl)-
  • Acetyl enheptin
  • acetylenheptin
  • Acinitrazol
  • Acinitrazole
  • Ametoterina
  • Aminitrazol
  • Aminitrazole
  • Aminitrozol
  • Aminitrozole
  • Aminitrozolum
  • CL 5,279
  • CL 5279
  • Cyzine Premix
  • DINITOLMIDE SOLUTION 100 NG/5L IN ACETO
  • 2-ACETAMIDO-5-NITROTHIAZOLE 97+%
  • N-(5-nitro-1,3-thiazol-2-yl)ethanamide
  • cyzinepremix
  • Enheptin A
  • enheptina
  • Gynofon
  • Lavoflagin
  • N-(5-Nitro-1,3-thiazol-2-yl)acetamide
  • n-(5-nitro-2-thiazolyl)-acetamid
  • Nitasol
  • Nitazol
  • Nitazole
  • Nithiamide
  • Pleocide
  • Thiazole, 2-acetamido-5-nitro-
  • Trichlorad
  • Trichloral
  • Trichocid
  • Trichoman
  • Trichorad
  • Trichoral
  • Tricogen
  • Tricolaval
  • Tricoral
  • Tricosteril
  • Trikolaval
  • Tritheon
  • N-(5-nitrothiazol-2-yl)acetamide
  • 2-Acetylamino-5-nitrothiazole Standard
  • 2-Acetamido-5-nitrothiazole &gt
  • 2-Acetamido-5-nitrothiazole, ≥ 98.0%
  • C10012500 2-Acetamido-5-nitrothiazole
  • Lurasidone Impurity 104
  • Nithiamide, 10 mM in DMSO
  • 140-40-9