TIZOXANIDE
- Product Name
- TIZOXANIDE
- CAS No.
- 173903-47-4
- Chemical Name
- TIZOXANIDE
- Synonyms
- TIZ;4-ABAH;NSC640;NSC 640;NSC-640;NSC 697856;TIZOXANIDE;Tizoxanide, >98%;Desacetyl-nitazoxanide;Nitazoxanide Desacetyl Impurity
- CBNumber
- CB9649941
- Molecular Formula
- C10H7N3O4S
- Formula Weight
- 265.25
- MOL File
- 173903-47-4.mol
TIZOXANIDE Property
- Melting point:
- 279-281°(dec)
- Density
- 1.644±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 6.70±0.50(Predicted)
- color
- Off-White to Pale Yellow
Safety
- HS Code
- 2934.10.1000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T3862
- Product name
- Tizoxanide
- Packaging
- 25MG
- Price
- $125
- Updated
- 2024/03/01
- Product number
- T3862
- Product name
- Tizoxanide
- Packaging
- 100MG
- Price
- $339
- Updated
- 2024/03/01
- Product number
- 13693
- Product name
- Tizoxanide
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 13693
- Product name
- Tizoxanide
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 13693
- Product name
- Tizoxanide
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
TIZOXANIDE Chemical Properties,Usage,Production
Description
Tizoxanide is an active metabolite of the antiparasitic nitazoxanide . Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 μg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 μM for both).
Chemical Properties
Light Yellow Powder
Uses
A metabolite of Nitazoxanide; a potent inhibitor of hepatitis B virus and hepatitis C virus.
Uses
A metabolite of Nitazoxanide (N490100); a potent inhibitor of hepatitis B virus and hepatitis C virus. Kills Mycobacterium tuberculosis.
Definition
ChEBI: Desacetyl-nitazoxanide is a member of salicylamides.
in vitro
previous study found that tizoxanide showed potent inhibition of both hbv and hcv replication. tizoxanide also exhibited selective inhibition of intracellular hbv replication and extracellular virus production by 2.2.15 cells. tizoxanide could selectively reduce intracellular hcv replication in ava5 cells. moreover, the combination of tizoxanide with either recombinant human interferon alpha 2b (ifnα), or an ns5b (hcv polymerase) inhibitor, 2′-c-methyl cytidine, resulted in synergistic interactions against hcv replication. in addition, antiviral activities of tizoxanide against a full-length genotype 1a replicon were equivalent to that observed for ava5 cells [1].
in vivo
animal study in an immunosuppressed rat model suggested that relapses were less frequent after treatment with nitazoxanide, the parent drug of tizoxanide, than with the non-absorbable sinefungin and paromomycin [2].
IC 50
0.17 to 0.21 μm for civs
References
[1] korba be,montero ab,farrar k,gaye k,mukerjee s,ayers ms,rossignol jf. nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis b virus and hepatitis c virus replication. antiviral res.2008 jan;77(1):56-63.
[2] gargala g,delaunay a,li x,brasseur p,favennec l,ballet jj. efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against cryptosporidium parvum development in sporozoite-infected hct-8 enterocytic cells. j antimicrob chemother.2000 jul;46(1):57-60.
TIZOXANIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TIZOXANIDE manufacturers
- Product
- Tizoxanide 173903-47-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Tizoxanide 173903-47-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- TIZOXANIDE 173903-47-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05