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TIZOXANIDE

Product Name
TIZOXANIDE
CAS No.
173903-47-4
Chemical Name
TIZOXANIDE
Synonyms
TIZ;4-ABAH;NSC640;NSC 640;NSC-640;NSC 697856;TIZOXANIDE;Tizoxanide, >98%;Desacetyl-nitazoxanide;Nitazoxanide impurity 01
CBNumber
CB9649941
Molecular Formula
C10H7N3O4S
Formula Weight
265.25
MOL File
173903-47-4.mol
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TIZOXANIDE Property

Melting point:
279-281°(dec)
Density 
1.644±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
6.70±0.50(Predicted)
color 
Off-White to Pale Yellow
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Safety

HS Code 
2934.10.1000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3862
Product name
Tizoxanide
Packaging
25MG
Price
$125
Updated
2024/03/01
TCI Chemical
Product number
T3862
Product name
Tizoxanide
Packaging
100MG
Price
$339
Updated
2024/03/01
Cayman Chemical
Product number
13693
Product name
Tizoxanide
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
13693
Product name
Tizoxanide
Purity
≥95%
Packaging
5mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
13693
Product name
Tizoxanide
Purity
≥95%
Packaging
10mg
Price
$214
Updated
2024/03/01
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TIZOXANIDE Chemical Properties,Usage,Production

Description

Tizoxanide is an active metabolite of the antiparasitic nitazoxanide . Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 μg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 μM, respectively), inhibits influenza A replication (EC50s = 0.3-1 μM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 μM for both).

Chemical Properties

Light Yellow Powder

Uses

A metabolite of Nitazoxanide; a potent inhibitor of hepatitis B virus and hepatitis C virus.

Uses

A metabolite of Nitazoxanide (N490100); a potent inhibitor of hepatitis B virus and hepatitis C virus. Kills Mycobacterium tuberculosis.

Definition

ChEBI: Desacetyl-nitazoxanide is a member of salicylamides.

in vitro

previous study found that tizoxanide showed potent inhibition of both hbv and hcv replication. tizoxanide also exhibited selective inhibition of intracellular hbv replication and extracellular virus production by 2.2.15 cells. tizoxanide could selectively reduce intracellular hcv replication in ava5 cells. moreover, the combination of tizoxanide with either recombinant human interferon alpha 2b (ifnα), or an ns5b (hcv polymerase) inhibitor, 2′-c-methyl cytidine, resulted in synergistic interactions against hcv replication. in addition, antiviral activities of tizoxanide against a full-length genotype 1a replicon were equivalent to that observed for ava5 cells [1].

in vivo

animal study in an immunosuppressed rat model suggested that relapses were less frequent after treatment with nitazoxanide, the parent drug of tizoxanide, than with the non-absorbable sinefungin and paromomycin [2].

IC 50

0.17 to 0.21 μm for civs

References

[1] korba be,montero ab,farrar k,gaye k,mukerjee s,ayers ms,rossignol jf. nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis b virus and hepatitis c virus replication. antiviral res.2008 jan;77(1):56-63.
[2] gargala g,delaunay a,li x,brasseur p,favennec l,ballet jj. efficacy of nitazoxanide, tizoxanide and tizoxanide glucuronide against cryptosporidium parvum development in sporozoite-infected hct-8 enterocytic cells. j antimicrob chemother.2000 jul;46(1):57-60.

TIZOXANIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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TIZOXANIDE Suppliers

Canada 1 China 94 Europe 1 India 6 Japan 1 United Kingdom 1 United States 13 Global 117
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18070
Advantage
56
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
Shanghai JiYi Biotechnology Co. Ltd.
Tel
13621943973
Fax
-
Email
sales@shjiyipharmatech.com
Country
China
ProdList
1166
Advantage
55
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View Lastest Price from TIZOXANIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Tizoxanide 173903-47-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Tizoxanide 173903-47-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
TIZOXANIDE 173903-47-4
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

173903-47-4, TIZOXANIDERelated Search:

Nitazoxanide 2-Amino-5-nitrothiazole Nitazoxanide Impurity 2 Thiacloprid Thiamethoxam

  • TIZOXANIDE
  • 2-hydroxy-N-(5-nitrothiazol-2-yl)benzaMide
  • Benzamide, 2-hydroxy-N-(5-nitro-2-thiazolyl)-
  • 2-Hydroxy-N-(5-nitro-2-thiazolyl)benzamide
  • NSC 697856
  • TIZ
  • 2-hydroxy-N-(5-nitro-1,3-thiazol-2-yl)benzamide
  • Tizoxanide, >98%
  • Nitazoxanide Desacetyl Impurity
  • Desacetyl-nitazoxanide
  • 4-ABAH
  • NSC 640
  • NSC640
  • NSC-640
  • Desacetyl-nitazoxanide|||TIZ
  • Nitazoxanide impurity 01
  • 173903-47-4
  • Aromatics Compounds
  • Aromatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Inhibitors