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CHAPS

Product Name
CHAPS
CAS No.
75621-03-3
Chemical Name
CHAPS
Synonyms
CHAPS;TREND;3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE;N,N-Dimethyl-N-(3-sulfonatopropyl)-3-[(3α,7α,12α-trihydroxy-24-oxo-5β-cholan-24-yl)amino]propylaminium;N,N-Dimethyl-N-(3-sulfonatopropyl)-3-[[3α,7α,12α-trihydroxy-24-oxo-5β-cholan-24-yl]amino]-1-propaneaminium;1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-[[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, inner salt;CHAPS, 98+%;CHAPS buffer;CHAPS 100 mM;CHAPS, >=99%
CBNumber
CB4165631
Molecular Formula
C32H58N2O7S
Formula Weight
614.88
MOL File
75621-03-3.mol
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CHAPS Property

Melting point:
156-158°C (dec.)
Density 
1.01 g/mL at 20 °C
refractive index 
1.6900 (estimate)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL at 20 °C, clear, colorless
form 
Crystalline Powder
color 
White
Odor
Odorless
PH Range
6
Water Solubility 
Soluble in water (10 mg/ml). Soluble in DMF and hot methanol.
Sensitive 
Hygroscopic
Merck 
2044
Stability:
Moisture Sensitive: Hydroscopic
InChIKey
UMCMPZBLKLEWAF-RFCNGIAKSA-N
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-61
Safety Statements 
26-36-45-53
WGK Germany 
3
F 
3-10
HS Code 
29239000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
220201
Product name
CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
Purity
CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
Packaging
1g
Price
$81
Updated
2024/03/01
Sigma-Aldrich
Product number
220201
Product name
CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
Purity
CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
Packaging
5G
Price
$239
Updated
2024/03/01
Sigma-Aldrich
Product number
220201
Product name
CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
Purity
CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
Packaging
10g
Price
$398
Updated
2024/03/01
Sigma-Aldrich
Product number
220201
Product name
CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
Purity
CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
Packaging
25g
Price
$786
Updated
2024/03/01
Sigma-Aldrich
Product number
220201
Product name
CHAPS,MolecularBiologyGrade-CAS75621-03-3-Calbiochem
Purity
CAS75621-03-3isazwitterionicdetergentthatcombinesfeaturesofbilesalts
Packaging
250g
Price
$2600
Updated
2024/03/01
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CHAPS Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder. CHAPS may be synthesized from cholic acid and is zwitterionic due to its quaternary ammonium and sulfonate groups; it is structurally similar to certain bile acids, such as taurodeoxycholic acid and taurochenodeoxycholic acid. It is sparingly soluble or insoluble in aqueous solution due to their native hydrophobicity.

Uses

CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. It is used in the laboratory to dissolve biological macromolecules such as proteins. It acts as a non-denaturing solvent used in purification of membrane proteins. It is also useful in conjunction with nonionic detergents like Triton X-100. Further, it is used as a non-denaturing zwitterionic detergent for membrane biochemistry.

Application

CHAPS is often used as a detergent in the solubilization and purification of membrane proteins for several advantageous reasons. CHAPS detergent is non-denaturing to membrane proteins, can solubilize proteins, disaggregate protein-protein interactions. CHAPS is also useful in ion exchange chromatography and isoelectric focusing as it is zwitterionic and does not exhibit a net charge between pH 2 to 12. It is suitable for isolation of membrane proteins with the following features such as sufficient protein solubilization capability, no denaturing or inactivation of proteins, no interference with protein activities, no precipitation at 4°C, appropriate critical micelle concentrations (CMC) and micelle size, no absorption in the UV region, no toxicity and availability of detergent detection methods.

General Description

CHAPS is a stabilizing agent that can be used to prevent aggregation, precipitation or proteolysis of proteins in solution.

Biological Activity

CHAPS is a zwitterionic nondenaturing detergent for solubilizing membrane proteins. Combines the properties of both the sulfobetaine-type and bile-acid detergents.

storage

Room temperature

Purification Methods

Triturate this zwitterionic detergent (~50g) with MeOH (200ml), then triturate it with Me2CO (500mL), collect it by vacuum filtration and dry it thoroughly at ~20o. Recrystallise it at 0o from absolute MeOH followed by drying in vacuo to constant weight. It should give one spot with RF 0.32 by TLC on silica gel G in 95% MeOH/5% NH4OH and visualized with iodine vapour; the tertiary amine precursor has RF 0.40. It has low UV absorption (1% in H2O: A280nm is 0.029 and A260nm is 0.035), and the CMC (critical micellar concentration) is 8mM. It is soluble in H2O, MeOH, Me2SO but insoluble in Me2CO, MeCN, hexane, toluene and xylene. [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.] CHAPSO (3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate betaine) [82473-24-3] M 630.89, m 184-196o, [ ] D +19o (c 2, H2O), pKEst (1) ~<2 (acidic), pKEst(2) ~9 (basic). Dissolve this zwitterionic detergent (~ 60g) in 40% aqueous MeOH and stir it with the mixed-bed ion-exchange resin RG-501 x 8 (100g, Bio-Rad) until the pH of the supernatant is ~ 7. Filter off the resin and evaporate the filtrate to dryness under reduced pressure. Check for homogeneity by TLC on silica gel G in 95% MeOH/5% NH4OH and visualize the spot with iodine vapour (see CHAPS above). [Hjelmeland et al. Anal Biochem 130 72 1983, Matuo et al. Methods Enzymol 198 155 1991.]

CHAPS Preparation Products And Raw materials

Raw materials

Preparation Products

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CHAPS Suppliers

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View Lastest Price from CHAPS manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 75621-03-3
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-21
WUHAN FORTUNA CHEMICAL CO., LTD
Product
CHAPS 75621-03-3
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
3500kg/month
Release date
2021-09-10
Hebei Guanlang Biotechnology Co., Ltd.
Product
3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate 75621-03-3
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2022-09-20

75621-03-3, CHAPSRelated Search:

4-Dimethylaminobenzaldehyde Cocamidopropyl betaine 4-Amino-benzenesulfonic acid monosodium salt Sulfanilic acid N,N,N',N'-Tetramethylazodicarboxamide Sodium allylsulfonate Nickel bis(sulphamidate) Sulfamic acid 10-NONADECANOL N-OCTANAMIDE Cyclopentanemethanol 2,5-DIMETHYLCYCLOHEXANOL N-METHYL-N-OCTADECYLAMINE 1,16-HEXADECANEDIOL 2,6,8-TRIMETHYL-4-NONANOL (+/-)-NEOMENTHOL 7-AMINO-HEPTAN-1-OL Chapso

  • CHAPS
  • CHAPS (3-((3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO)PROPANESULFONATE)
  • 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANE SULPHONATE (ULTRAPURE)
  • 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]PROPANESULFONAT(CHAPS)
  • 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulphonate (Ultrapure) >99.0%
  • CHAPS, 98+%
  • CHAPS extrapure
  • 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-[[(3a,5b,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, inner salt
  • Cholane, 1-propanaminium deriv.
  • N,N-Dimethyl-N-(3-sulfonatopropyl)-3-[(3α,7α,12α-trihydroxy-24-oxo-5β-cholan-24-yl)amino]propylaminium
  • N,N-Dimethyl-N-(3-sulfonatopropyl)-3-[[3α,7α,12α-trihydroxy-24-oxo-5β-cholan-24-yl]amino]-1-propaneaminium
  • N-[3-(3-Sulfonatopropyldimethylaminio)propyl]-3α,7α,12α-trihydroxy-5β-cholan-24-amide
  • N,N-Dimethyl-N-(3-sulfopropyl)-3-[[(3a,5,7a,12a)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-1-propanaminium Inner Salt
  • 3-[(3-Cholanidopropyl)dimethylammonio]-1-propanesulfonate
  • 3-[(3-Cholamidopropyl)dimethylammonio]-1-propane sulfonate ,98%
  • 3-(3-CHOLAMIDOPROPYL)DIMETHYL-AMMONIO-1-PROPANESULFONATE RESEARCH
  • CHAPS-SOL GRADE
  • 3-((3-Cholamidopropy
  • 3-cholamidopropyl)dimethyl-ammonio]-1-propanesulfonate)
  • CHAPS buffer
  • CHAPS, Molecular Biology Grade
  • 3-[(3-cholamidopropyl)dimethylammonio]propane-1-sulfonate
  • 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfote
  • CHAPS 100 mM
  • CHAPS, 3-[(3-Chloamidopropyl)dimethyl- ammonium]-1- propanesulfonate
  • 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE
  • 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANE SULPHONATE
  • 3-((3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO)PROPANESULFONATE
  • 3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate
  • 3-[(3-Chloromidopropyl)dimethylammonio]-1-propanesulfonate
  • CHAPS 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate
  • CHAPS Solution
  • CHAPS ELECTROPHORESIS REAGENT
  • Chaps3-[3-(Cholamidopropyl)Dimethylamonio]-1-Propanesulfonate
  • 3-[(3-Cholamidopropyl)dimethylammonio]propanesulfonic acid
  • CHAPS,HighPurity
  • 3-(3-(cholamidopropyl)dimethyl
  • Cholamidopropyl)dimethylammonio]-1-propanesulfonate
  • 1-Propanaminium, N,N-dimethyl-N-(3-sulfopropyl)-3-(3.alpha.,5.beta.,7.alpha.,12.alpha.)-3,7,12-trihydroxy-24-oxocholan-24-ylamino-, inner salt
  • CHAPS,CRYSTALLINEPOWDER,ULTRAPURE
  • TREND
  • 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate (CHAPS)
  • 3-[(3-cholaMidopropyl)diMethylaMMonio]propanesulfonate(CHAPS)
  • N,N-DiMethyl-N-(3-sulfopropyl)-3-[[(3α,5β,7α,12α)-3,7,12-trihydroxy- 24-oxocholan-24-yl]aMino]-1-propanaMiniuM Inner Salt
  • 3-(Dimethyl(3-((4R)-4-((3R,5S,7R,10S,12S,13R,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)propyl)ammonio)propane-1-sulfonate
  • CHAPS 100 mM solution
  • CHAPS Vetec(TM) reagent grade, 96%
  • CHAPS, >=99%
  • BRADFORD REAGENT BIOTECHNOLOGY GRADE
  • 3-((3-((4R)-4-((10S,13R,17R)-10,13-DiMethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanaMido)propyl)diMethylaMMonio)propane-1-sulfonate
  • MEDIABAG ST FOR 3375 ML BPW
  • MEDIABAG ST FOR 4000 ML BPW
  • MEDIABAG ST FOR 450ML BPW 10 X10 ST
  • SMMP MEDIUM CONC.
  • TSA PETRI 9CM
  • 3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate &gt
  • 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate ISO 9001：2015 REACH
  • New reaserching product 3-((3-Cholamidopropyl)dimethylammonium)-1-propanesulfonate CAS 75621-03-3 with best price