2-CHLORO-1,8-NAPHTHYRIDINE
Application- Product Name
- 2-CHLORO-1,8-NAPHTHYRIDINE
- CAS No.
- 15936-10-4
- Chemical Name
- 2-CHLORO-1,8-NAPHTHYRIDINE
- Synonyms
- 2-CHLORO-1,8-NAPHTHYRIDINE;1,8-Naphthyridine, 2-chloro-
- CBNumber
- CB4169679
- Molecular Formula
- C8H5ClN2
- Formula Weight
- 164.59
- MOL File
- 15936-10-4.mol
2-CHLORO-1,8-NAPHTHYRIDINE Property
- Melting point:
- 138-139 °C
- Boiling point:
- 281.5±20.0 °C(Predicted)
- Density
- 1.349±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.04±0.30(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C384550
- Product name
- 2-Chloro-1,8-naphthyridine
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- OR939109
- Product name
- 2-Chloro-1,8-naphthyridine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $86
- Updated
- 2021/12/16
- Product number
- 3H32-5-VT
- Product name
- 2-Chloro-1,8-naphthyridine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 8014AA
- Product name
- 2-Chloro-1,8-naphthyridine
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- HCH0118383
- Product name
- 2-CHLORO-1,8-NAPHTHYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.12
- Updated
- 2021/12/16
2-CHLORO-1,8-NAPHTHYRIDINE Chemical Properties,Usage,Production
Application
2-Chloro-1,8-Naphthidine has shown great activity in the design of novel antibiotics and drugs for the treatment of cardiovascular diseases, and is an important breakthrough for future drug development.
Synthesis
15936-09-1
15936-10-4
General procedure for the synthesis of 2-chloro-1,8-naphthyridine from 1,8-naphthyridin-2(1H)-one: Phosphoryl chloride (86 mL, 924 mmol) was added to 1,8-naphthyridin-2(1H)-one (9.00 g, 61.6 mmol), and the reaction mixture was heated to 100°C and maintained for 1 hour. Upon completion of the reaction, the mixture was cooled and the excess phosphorus trichloride was removed by evaporation. The residue was dissolved in dichloromethane (100 mL) and alkalized by slowly adding saturated sodium bicarbonate solution. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the solvent evaporated to afford the target compound 2-chloro-1,8-naphthyridine as a white solid (7 g, 70% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.50 (1H, d, J=8.4 Hz), 7.52 (1H, dd, J=8.1 Hz and 4.3 Hz), 8.16 (1H, d, J=8.4 Hz), 8.22 (1H, dd, J=8.1 Hz and 2.0 Hz), 9.12 (1H, dd, J= 4.3 Hz and 2.0 Hz).
References
[1] Journal of the American Chemical Society, 2015, vol. 137, # 8, p. 2996 - 3003
[2] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/130968, 2016, A1. Location in patent: Page/Page column 161
2-CHLORO-1,8-NAPHTHYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-1,8-NAPHTHYRIDINE Suppliers
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
View Lastest Price from 2-CHLORO-1,8-NAPHTHYRIDINE manufacturers
- Product
- 2-CHLORO-1,8-NAPHTHYRIDINE 15936-10-4
- Price
- US $0.80-1.80/KG
- Min. Order
- 1KG
- Purity
- 95%~99.99%
- Supply Ability
- 10 MT/ Month
- Release date
- 2020-11-05
- Product
- 2-CHLORO-1,8-NAPHTHYRIDINE 15936-10-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-30