2-CHLORO-1,8-NAPHTHYRIDINE

Application

Product Name: 2-CHLORO-1,8-NAPHTHYRIDINE
CAS No.: 15936-10-4
Chemical Name: 2-CHLORO-1,8-NAPHTHYRIDINE
Synonyms: 2-CHLORO-1,8-NAPHTHYRIDINE;1,8-Naphthyridine, 2-chloro-
CBNumber: CB4169679
Molecular Formula: C8H5ClN2
Formula Weight: 164.59
MOL File: 15936-10-4.mol

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2-CHLORO-1,8-NAPHTHYRIDINE Property

Melting point:: 138-139 °C
Boiling point:: 281.5±20.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 2.04±0.30(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C384550
Product name: 2-Chloro-1,8-naphthyridine
Packaging: 100mg
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: OR939109
Product name: 2-Chloro-1,8-naphthyridine
Purity: 96%
Packaging: 250mg
Price: $86
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-5-VT
Product name: 2-Chloro-1,8-naphthyridine
Purity: 96%
Packaging: 250mg
Price: $138
Updated: 2021/12/16

AK Scientific

Product number: 8014AA
Product name: 2-Chloro-1,8-naphthyridine
Packaging: 250mg
Price: $190
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0118383
Product name: 2-CHLORO-1,8-NAPHTHYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $496.12
Updated: 2021/12/16

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2-CHLORO-1,8-NAPHTHYRIDINE Chemical Properties,Usage,Production

Application

2-Chloro-1,8-Naphthidine has shown great activity in the design of novel antibiotics and drugs for the treatment of cardiovascular diseases, and is an important breakthrough for future drug development.

Synthesis

15936-09-1

15936-10-4

General procedure for the synthesis of 2-chloro-1,8-naphthyridine from 1,8-naphthyridin-2(1H)-one: Phosphoryl chloride (86 mL, 924 mmol) was added to 1,8-naphthyridin-2(1H)-one (9.00 g, 61.6 mmol), and the reaction mixture was heated to 100°C and maintained for 1 hour. Upon completion of the reaction, the mixture was cooled and the excess phosphorus trichloride was removed by evaporation. The residue was dissolved in dichloromethane (100 mL) and alkalized by slowly adding saturated sodium bicarbonate solution. The organic layer was separated, dried with anhydrous sodium sulfate, filtered and the solvent evaporated to afford the target compound 2-chloro-1,8-naphthyridine as a white solid (7 g, 70% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 7.50 (1H, d, J=8.4 Hz), 7.52 (1H, dd, J=8.1 Hz and 4.3 Hz), 8.16 (1H, d, J=8.4 Hz), 8.22 (1H, dd, J=8.1 Hz and 2.0 Hz), 9.12 (1H, dd, J= 4.3 Hz and 2.0 Hz).

References

[1] Journal of the American Chemical Society, 2015, vol. 137, # 8, p. 2996 - 3003
[2] Patent: WO2005/47279, 2005, A1. Location in patent: Page/Page column 50
[3] Patent: WO2016/130968, 2016, A1. Location in patent: Page/Page column 161

2-CHLORO-1,8-NAPHTHYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-1,8-NAPHTHYRIDINE Suppliers

China 63 Germany 1 India 1 United Kingdom 1 United States 4 Global 70

Accela ChemBio Inc.

Tel: +1-858-6993322
Fax: (+1)-858-876-1948
Email: info@accelachem.com
Country: United States
ProdList: 21193
Advantage: 58

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Synthonix Inc

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Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Milestone PharmTech LLC

Tel: --
Fax: --
Email: sales@milestonepharmtech.com
Country: United States
ProdList: 1316
Advantage: 47

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View Lastest Price from 2-CHLORO-1,8-NAPHTHYRIDINE manufacturers

Career Henan Chemica Co

Product: 2-CHLORO-1,8-NAPHTHYRIDINE 15936-10-4
Price: US $0.80-1.80/KG
Min. Order: 1KG
Purity: 95%~99.99%
Supply Ability: 10 MT/ Month
Release date: 2020-11-05

Nanjing jinheyou Trading Co., Ltd.

Product: 2-CHLORO-1,8-NAPHTHYRIDINE 15936-10-4
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-30

15936-10-4, 2-CHLORO-1,8-NAPHTHYRIDINERelated Search:

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2-CHLORO-1,8-NAPHTHYRIDINE

1,8-Naphthyridine, 2-chloro-

15936-10-4