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ANTHRALIN

Product Name
ANTHRALIN
CAS No.
1143-38-0
Chemical Name
ANTHRALIN
Synonyms
DITHRANOL;Anthranol;1,8,9-ANTHRACENETRIOL;9-anthrol;Rydex;Psorin;Micanol;Psorider;Batridol;Psoriderm
CBNumber
CB4170871
Molecular Formula
C14H10O3
Formula Weight
226.23
MOL File
1143-38-0.mol
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ANTHRALIN Property

Melting point:
178-181 °C (lit.)
Boiling point:
464.1±45.0 °C(Predicted)
Density 
1.419±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Practically insoluble in water, soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
form 
Solid
pka
7.16±0.20(Predicted)
color 
Yellow to Orange to Dark Yellow
Water Solubility 
Insoluble in water. Soluble in acetic acid, chloroform (20 mg/mL), acetone, benzene, solutions of alkali hydroxides, fixed oil. Slightly soluble in 95% ethanol, alcohol, ether, and glacial acetic acid.
Merck 
14,684
BRN 
2054360
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
NUZWLKWWNNJHPT-UHFFFAOYSA-N
CAS DataBase Reference
1143-38-0(CAS DataBase Reference)
IARC
3 (Vol. 13; Sup 7) 1987
EPA Substance Registry System
Dithranol (1143-38-0)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-45
Safety Statements 
26-53-45
WGK Germany 
3
RTECS 
CB8927000
HS Code 
29144000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D2773
Product name
Dithranol
Purity
≥90% (HPLC)
Packaging
1g
Price
$151
Updated
2024/03/01
Sigma-Aldrich
Product number
1039006
Product name
Anthralin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$280
Updated
2024/03/01
TCI Chemical
Product number
T1166
Product name
Dithranol
Packaging
1G
Price
$33
Updated
2024/03/01
TCI Chemical
Product number
T1166
Product name
Dithranol
Purity
>95.0%(HPLC)(T)
Packaging
10g
Price
$408
Updated
2024/03/01
Cayman Chemical
Product number
28371
Product name
Anthralin
Packaging
1g
Price
$32
Updated
2024/03/01
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ANTHRALIN Chemical Properties,Usage,Production

Description

Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation. It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 μM. It also decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 μM. Anthralin (0.25 μM) decreases the expression of β-defensin-2 and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs. It also inhibits leukotriene B4 (LTB4; ) production, stimulated by the calcium ionophore A23187 , from human neutrophils (IC50 = 7 μM). Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.

Chemical Properties

Yellow Crystalline Solid

Uses

Antipsoriatic

Indications

Anthralin (Anthra-Derm) is a potent reducing agent whose mechanism of action is unknown. It is approved for the treatment of psoriasis and also may be helpful in alopecia areata. The major toxicities are discoloration of skin, hair, and nails and irritant dermatitis.

Definition

ChEBI: An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.

brand name

Anthra-Derm (Dermik); DrithoCreme (Dermik); Drithoscalp (Dermik); Lasan (Stiefel).

General Description

Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.

Air & Water Reactions

Unstable in air when in alkaline solution. Insoluble in water.

Reactivity Profile

ANTHRALIN reacts as a weak acid. Soluble in aqueous bases. May react with strong oxidizing agents. May be sensitive to light and moisture .

Hazard

Very irritating. Do not use on scalp or near eyes.

Fire Hazard

Flash point data are not available for ANTHRALIN; however, ANTHRALIN is probably combustible.

Side effects

Anthralin's side effects include pruritus, erythema, scaling, folliculitis, and lymphadenopathy. Staining of skin and clothes can also be an issue.

ANTHRALIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ANTHRALIN Suppliers

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View Lastest Price from ANTHRALIN manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
ANTHRALIN 1143-38-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28
Hebei Yanxi Chemical Co., Ltd.
Product
ANTHRALIN 1143-38-0
Price
US $15.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-21
Shaanxi Dideu Medichem Co. Ltd
Product
ANTHRALIN 1143-38-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-08-16

1143-38-0, ANTHRALINRelated Search:

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