ANTHRALIN

Product Name: ANTHRALIN
CAS No.: 1143-38-0
Chemical Name: ANTHRALIN
Synonyms: DITHRANOL;Anthranol;1,8,9-ANTHRACENETRIOL;9-anthrol;Rydex;Psorin;Micanol;Psorider;Batridol;Psoriderm
CBNumber: CB4170871
Molecular Formula: C14H10O3
Formula Weight: 226.23
MOL File: 1143-38-0.mol

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ANTHRALIN Property

Melting point:: 178-181 °C (lit.)
Boiling point:: 464.1±45.0 °C(Predicted)
Density: 1.419±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Practically insoluble in water, soluble in methylene chloride, sparingly soluble in acetone, slightly soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
form: Solid
pka: 7.16±0.20(Predicted)
color: Yellow to Orange to Dark Yellow
Water Solubility: Insoluble in water. Soluble in acetic acid, chloroform (20 mg/mL), acetone, benzene, solutions of alkali hydroxides, fixed oil. Slightly soluble in 95% ethanol, alcohol, ether, and glacial acetic acid.
Merck: 14,684
BRN: 2054360
Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey: NUZWLKWWNNJHPT-UHFFFAOYSA-N
CAS DataBase Reference: 1143-38-0(CAS DataBase Reference)
IARC: 3 (Vol. 13; Sup 7) 1987
EPA Substance Registry System: Dithranol (1143-38-0)

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-45
Safety Statements: 26-53-45
WGK Germany: 3
RTECS: CB8927000
HS Code: 29144000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D2773
Product name: Dithranol
Purity: ≥90% (HPLC)
Packaging: 1g
Price: $151
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1039006
Product name: Anthralin
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $280
Updated: 2024/03/01

TCI Chemical

Product number: T1166
Product name: Dithranol
Packaging: 1G
Price: $33
Updated: 2024/03/01

TCI Chemical

Product number: T1166
Product name: Dithranol
Purity: >95.0%(HPLC)(T)
Packaging: 10g
Price: $408
Updated: 2024/03/01

Cayman Chemical

Product number: 28371
Product name: Anthralin
Packaging: 1g
Price: $32
Updated: 2024/03/01

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ANTHRALIN Chemical Properties,Usage,Production

Description

Anthralin is an anthrone inhibitor of keratinocyte proliferation and a modulator of differentiation. It increases apoptosis and inhibits proliferation of normal human keratinocytes (NHKs) when used at a concentration of 2.5 μM. It also decreases the mitochondrial membrane potential, increases cytochrome c release, and induces perinuclear mitochondrial clustering in NHKs when used at a concentration of 5 μM. Anthralin (0.25 μM) decreases the expression of β-defensin-2 and S100 calcium-binding protein A9 (S100A9) and increases the expression of IL-6 and IL-8 in IL-17A- and IL-22-stimulated NHKs. It also inhibits leukotriene B₄ (LTB₄; ) production, stimulated by the calcium ionophore A23187 , from human neutrophils (IC₅₀ = 7 μM). Topical anthralin (0.1%) induces hair regrowth in a Dundee experimental bald rat (DEBR) model of alopecia areata.

Chemical Properties

Yellow Crystalline Solid

Uses

Antipsoriatic

Indications

Anthralin (Anthra-Derm) is a potent reducing agent whose mechanism of action is unknown. It is approved for the treatment of psoriasis and also may be helpful in alopecia areata. The major toxicities are discoloration of skin, hair, and nails and irritant dermatitis.

Definition

ChEBI: An anthracene compound derived by the substitution of -OH groups for hydrogen at C-1 and C-8, and with an oxo group at C-9.

brand name

Anthra-Derm (Dermik); DrithoCreme (Dermik); Drithoscalp (Dermik); Lasan (Stiefel).

General Description

Lemon yellow leaflets or plates or an orange powder. Melting point 176-181°C. No odor or taste. Insoluble in water. Moderately toxic by ingestion, inhalation and skin absorption. Used as a treatment for psoriasis.

Air & Water Reactions

Unstable in air when in alkaline solution. Insoluble in water.

Reactivity Profile

ANTHRALIN reacts as a weak acid. Soluble in aqueous bases. May react with strong oxidizing agents. May be sensitive to light and moisture .

Hazard

Very irritating. Do not use on scalp or near eyes.

Fire Hazard

Flash point data are not available for ANTHRALIN; however, ANTHRALIN is probably combustible.

Side effects

Anthralin's side effects include pruritus, erythema, scaling, folliculitis, and lymphadenopathy. Staining of skin and clothes can also be an issue.

ANTHRALIN Preparation Products And Raw materials

Raw materials

Preparation Products

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ANTHRALIN Suppliers

Belgium 1 Bulgaria 1 Canada 2 China 212 Europe 3 France 1 Germany 9 India 32 Italy 1 Japan 2 Poland 1 Slovakia 1 Spain 1 Switzerland 5 United Kingdom 10 United States 37 Global 319

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 5902
Advantage: 65

Beijing Nordhuns Chemical Technology Co.,Ltd

Tel: 010-84929330 13811281791
Fax: 010-84926806
Email: info@nordhuns.com
Country: China
ProdList: 296
Advantage: 58

Wuhan DKY Technology Co.,Ltd.

Tel: 027-81302411 15377658509
Email: zs@dkybpc.com
Country: China
ProdList: 2196
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

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View Lastest Price from ANTHRALIN manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: ANTHRALIN 1143-38-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: ANTHRALIN 1143-38-0
Price: US $15.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-21

Shaanxi Dideu Medichem Co. Ltd

Product: ANTHRALIN 1143-38-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2024-08-16

1143-38-0, ANTHRALINRelated Search:

FRANGULIN B Rhein 1,8-Dihydroxy-4,5-dinitroanthraquinone 1,2,5,8-TETRAHYDROXYANTHRAQUINONE Emodin-3-methyl ether Aloe emodin FRANGULIN A 1,8-Dihydroxyanthraquinone Emodin Chrysophanic acid ANTHRALIN Anthrone Anthracene SENNIDINE A 1,8-diphenoxyanthraquinone CYNODONTIN CATENARIN 1,8-dimethoxyanthraquinone

DITHRANOL

9-anthrol

DITHRANOL, 97+%

1,8,9-ANTHRACENETRIOL, PGE. WITH 10 X 10 MG

1,8,9-Trihydroxyanthracene, 97+%

Anthraforte

Micanol

Psorider

DITHRANOL,BP

DITHRANOL (1,8,9-TRIHYDROXYANTHRACENE)

Psoriderm

1,8,9-Anthracenetriol, 1,8-Dihydroxy-9(10H)-anthracenone, 1,8-Dihydroxyanthrone, Anthralin

1,8-Dihydroxy-9,10-dihydroanthracene-9-one

Anthralin (Dithranol)

Dithranol,1,8,9-Anthracenetriol, 1,8-Dihydroxy-9(10H)-anthracenone, 1,8-Dihydroxyanthrone, Anthralin

Anthralin (200 mg)

1,8-dihydroxy-9,10-dihydroanthracen-9-one

1,8-Dihydoxy-9(10H)-anthracenone

1,8,9-ANTHRACENETRIOL, MATRIX SUBSTANCE FOR MALDI-MS

DITHRANOL, ANTHRALIN

ANTHRALIN

1,8-DIHYDROXY-10H-ANTHRACEN-9-ONE

1,8-DIHYDROXY-9(10H)-ANTHRACENONE

1,8-DIHYDROXYANTHRONE

1,8,9-ANTHRACENETRIOL

batridrol

DithraSal

Psorin

1,8-dihydroxy-9(10h)-anthracenon

1,8-dihydroxy-anthron

Anthranol

Anthrone, 1,8-dihydroxy-

Batridol

DrithoCreme

Drithoscalp

Psodadrate

1,8-dihydroxyanthracen-9(10H)-one

Dithranol CRS

cignoline

ANTHRALIN USP/EP/BP

DithranolQ: What is Dithranol Q: What is the CAS Number of Dithranol Q: What is the storage condition of Dithranol

TIANFU CHEM---ANTHRALIN

ANTHRALIN Extra Pure

Anthralin (1039006)

Rydex

1,8,9-trihydroxyanthracene|||cignoline|||Anthralin

1143-38-0

003-11-6

KETONE

Analytical Chromatography Product Catalog

BioChemical

Biochemicals and Reagents

Analytical Reagents

Carbohydrates

Polysaccharide

Skin drugs, treatment of psoriasis

API

ANTRADERM