D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
- Product Name
- D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
- CAS No.
- 26993-30-6
- Chemical Name
- D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
- Synonyms
- SPA;S1P;SPHINGOSINE-1-PHOSPHATE;1-SPP;SPN-1-P;SPHINGOSINE-1-PO4;Quetiapine Impurity 54-d8;SPHINGOSINE-1-PHOSPHORIC ACID;Sphingosine-1-phosphate (d18:1);D-erythro-Sphingosin-1-phosphate
- CBNumber
- CB4181497
- Molecular Formula
- C18H38NO5P
- Formula Weight
- 379.47
- MOL File
- 26993-30-6.mol
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Property
- Melting point:
- 179-189°C
- Boiling point:
- 548.8±60.0 °C(Predicted)
- Density
- 1.094±0.06 g/cm3(Predicted)
- RTECS
- RG2260500
- storage temp.
- -20°C
- solubility
- methanol: THF: water (6:3:1): >0.5 mg/mL
- form
- waxy solid
- pka
- 1.76±0.10(Predicted)
- color
- yellow
- Sensitive
- Light Sensitive
- Stability:
- Moisture, Temperature Sensitive; Hygroscopic
- CAS DataBase Reference
- 26993-30-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 73914
- Product name
- Sphingosine 1-phosphate
- Purity
- ≥98.0% (TLC)
- Packaging
- 1mg
- Price
- $320
- Updated
- 2024/03/01
- Product number
- 567727
- Product name
- Sphingosine 1-phosphate
- Packaging
- 1mg
- Price
- $239
- Updated
- 2024/03/01
- Product number
- J66459
- Product name
- Sphingosine 1-phosphate
- Packaging
- 1mg
- Price
- $228
- Updated
- 2023/06/20
- Product number
- J66459
- Product name
- Sphingosine 1-phosphate
- Packaging
- 5mg
- Price
- $784
- Updated
- 2023/06/20
- Product number
- 62570
- Product name
- Sphingosine 1-phosphate
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $74
- Updated
- 2024/03/01
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Chemical Properties,Usage,Production
Description
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively). Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity. S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.
Chemical Properties
Off-White to Grey Powder
Uses
A ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.
Uses
A putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes. It mobilizes intracellular calcium stores, decreases cellular cAMP, activates phospholipase D and does not inhibitprotein kinase C.
Uses
D-erythro-Dihydrosphingosine-1-phosphate is a saturated analog of D-erythro-Sphingosine-1-phosphate a putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes.
Definition
ChEBI: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
General Description
Sphingosine-1-phosphate (S1P), a sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in yeasts and plants. Sphingosine kinases (SPKs) catalyzes the synthesis of S1P from spingosine and regulates S1P levels. It is the end product of ceramide catabolism and is metabolized to phosphoethanolamine and hexadecenal by S1P lyase. S1P is produced in endothelial cells.
Biological Activity
Endogenous second messenger involved in the control of cell proliferation and motility, and Ca 2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors, S1P 1-5 . Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.
Biochem/physiol Actions
A lipid second messenger that binds to S1P1 and S1P3 receptors. Mobilizes intracellular Ca2+ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Induces angiogenesis.
storage
Store at +4°C
References
1) Spiegel and Milstien (2003)?Sphingosine-1-phosphate: an enigmatic signaling lipid; Nat. Rev. Mol. Cell Biol.,?4?397 2) Rosen?et al. (2009)?Sphingosine-1-phosphate receptor signaling; Annu. Rev .Biochem.,?78?743 3) Maceyka?et al. (2012)?Sphingosine-1-phosphate signaling and its role in disease; Trends Cell Biol.,?22?50
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE manufacturers
- Product
- Sphingosine 1-phosphate 26993-30-6
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2018-12-25