ChemicalBook > CAS DataBase List > D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE

D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE

Product Name
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
CAS No.
26993-30-6
Chemical Name
D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
Synonyms
SPA;S1P;SPHINGOSINE-1-PHOSPHATE;1-SPP;SPN-1-P;SPHINGOSINE-1-PO4;Quetiapine Impurity 54-d8;SPHINGOSINE-1-PHOSPHORIC ACID;Sphingosine-1-phosphate (d18:1);D-erythro-Sphingosin-1-phosphate
CBNumber
CB4181497
Molecular Formula
C18H38NO5P
Formula Weight
379.47
MOL File
26993-30-6.mol
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D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Property

Melting point:
179-189°C
Boiling point:
548.8±60.0 °C(Predicted)
Density 
1.094±0.06 g/cm3(Predicted)
RTECS 
RG2260500
storage temp. 
-20°C
solubility 
methanol: THF: water (6:3:1): >0.5 mg/mL
form 
waxy solid
pka
1.76±0.10(Predicted)
color 
yellow
Sensitive 
Light Sensitive
Stability:
Moisture, Temperature Sensitive; Hygroscopic
CAS DataBase Reference
26993-30-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29225090
DEA Controlled Substances
CSCN: 1635
CAS SCH: IV
NARC: N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
73914
Product name
Sphingosine 1-phosphate
Purity
≥98.0% (TLC)
Packaging
1mg
Price
$320
Updated
2024/03/01
Sigma-Aldrich
Product number
567727
Product name
Sphingosine 1-phosphate
Packaging
1mg
Price
$239
Updated
2024/03/01
Alfa Aesar
Product number
J66459
Product name
Sphingosine 1-phosphate
Packaging
1mg
Price
$228
Updated
2023/06/20
Alfa Aesar
Product number
J66459
Product name
Sphingosine 1-phosphate
Packaging
5mg
Price
$784
Updated
2023/06/20
Cayman Chemical
Product number
62570
Product name
Sphingosine 1-phosphate
Purity
≥98%
Packaging
1mg
Price
$74
Updated
2024/03/01
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D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Chemical Properties,Usage,Production

Description

Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase that is secreted from cells and acts as an agonist at S1P receptors. It increases intracellular calcium levels in TAg-Jurkat cells expressing S1P1 and Gqi5, which allows for phospholipase C stimulation by Gi proteins, when used at a concentration of 200 nM, as well as in TAg-Jurkat cells expressing S1P2 and S1P3 receptors (EC50s = 8 and 11 nM, respectively). Intra- and extracellular levels of S1P vary spatially allowing it to function as an autocrine or paracrine factor, respectively, and dysregulation of S1P levels are associated with various disease states, such as inflammation and autoimmunity. S1P has a wide variety of effects, including an involvement in cell growth, angiogenesis, immunity, and neuroprotection.

Chemical Properties

Off-White to Grey Powder

Uses

A ligand for EDG-1 and EDG-3 and activator of GPR3, GPR6, and GPR12.

Uses

A putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes. It mobilizes intracellular calcium stores, decreases cellular cAMP, activates phospholipase D and does not inhibitprotein kinase C.

Uses

D-erythro-Dihydrosphingosine-1-phosphate is a saturated analog of D-erythro-Sphingosine-1-phosphate a putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrations with no toxic effects thereby making it a possible agent for prevention of tumor cell metastasis and inflammatory processes.

Definition

ChEBI: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1

General Description

Sphingosine-1-phosphate (S1P), a sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in yeasts and plants. Sphingosine kinases (SPKs) catalyzes the synthesis of S1P from spingosine and regulates S1P levels. It is the end product of ceramide catabolism and is metabolized to phosphoethanolamine and hexadecenal by S1P lyase. S1P is produced in endothelial cells.

Biological Activity

Endogenous second messenger involved in the control of cell proliferation and motility, and Ca 2+ mobilization. Acts as an agonist at sphingosine-1-phosphate receptors, S1P 1-5 . Effectors regulated include p38 MAP kinase, PLC, adenylyl cyclase, myosin light chain phosphatase and focal adhesion kinase.

Biochem/physiol Actions

A lipid second messenger that binds to S1P1 and S1P3 receptors. Mobilizes intracellular Ca2+ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Induces angiogenesis.

storage

Store at +4°C

References

1) Spiegel and Milstien (2003)?Sphingosine-1-phosphate: an enigmatic signaling lipid; Nat. Rev. Mol. Cell Biol.,?4?397 2) Rosen?et al. (2009)?Sphingosine-1-phosphate receptor signaling; Annu. Rev .Biochem.,?78?743 3) Maceyka?et al. (2012)?Sphingosine-1-phosphate signaling and its role in disease; Trends Cell Biol.,?22?50

D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

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D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE Suppliers

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View Lastest Price from D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE manufacturers

Career Henan Chemical Co
Product
Sphingosine 1-phosphate 26993-30-6
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

26993-30-6, D-ERYTHRO-SPHINGOSINE-1-PHOSPHATERelated Search:


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  • D-ERYTHRO-DIHYDROSPHINGOSINE-1-PHOSPHATE
  • D-ERYTHRO-SPHINGOSINE-1-PHOSPHATE
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  • SPHINGOSINE-1-PHOSPHATE, D-ERYTHRO
  • SPHINGOSINE-1-PHOSPHORIC ACID
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  • (2S,3R,4E)-2-AMino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate)
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  • 4-[(9-β-D-Ribofuranosyl-9H-purin-6-yl)amino]-benzenesulfonic acid sodium-potassium salt
  • 4-Octadecene-1,3-diol, 2-amino-, 1-(dihydrogen phosphate), (2S,3R,4E)-
  • Mouse Sphingosine-1-phosphate elisa kit
  • (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate
  • Quetiapine Impurity 54-d8
  • D-erythro Sphingosine-1-phosphate, agonist of S1P receptors
  • 26993-30-6
  • C18H38NO5P
  • proteins
  • Chemical Activators
  • Activators
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Inhibitors
  • Protein Kinase Inhibitors and Activators
  • Angiogenic FactorsSphingolipids
  • Angiogenesis
  • Cancer Research
  • Lipids in Cell Signaling
  • Sphingoid base 1-phosphatesCell Signaling and Neuroscience
  • Sphingoid bases
  • Sphingolipids
  • Lysophospholipid receptor and related