Isofagomine D-Tartrate

Isofagomine D-Tartrate Property

Melting point:

124-126°C

storage temp. 

-20°C Freezer, Under Inert Atmosphere

solubility 

Soluble in DMSO (up to 2 mg/ml)

form 

solid

color 

Off-white

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P308+P313IF exposed or concerned: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

Isofagomine D-Tartrate Chemical Properties,Usage,Production

Description

Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50?= 0.06 μM.1?Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2?Displays a direct pharmacological chaperone effect greatly increasing the amount of newly synthesized GlcCerase that traffics out of the ER.2

Chemical Properties

Isofagomine D-Tartrate is Off-White Solid

Uses

Isofagomine D-Tartrate is used as human acid ?glucosidase inhibitor and for the treatment of Gaucher disease

Uses

Used as human acid β-glucosidase inhibitor and for the treatment of Gaucher disease.

in vivo

References

[1] CHINAMI KURIYAMA . In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures[J]. Bioorganic & Medicinal Chemistry, 2008, 16 15: Pages 7330-7336. DOI:10.1016/j.bmc.2008.06.026
[2] RICHARD A STEET. The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 37: 13813-13818. DOI:10.1073/pnas.0605928103