Isofagomine D-Tartrate
- Product Name
- Isofagomine D-Tartrate
- CAS No.
- 957230-65-8
- Chemical Name
- Isofagomine D-Tartrate
- Synonyms
- Isofagomine tartrate;Isofagomine D-Tartrate;D-Isofagomine D-Tartrate;Afegostat DTartrate,Afegostat D Tartrate;Afegostat D-Tartrate (D-Isofagomine (D-Tartrate);Afegostat D-Tartrate (Synonyms: D-Isofagomine (D-Tartrate);(3R,4R,5R)-5-(Hydroxymethyl)-3,4-piperidinediol (2S,3S)-2,3-Dihydroxybutanedioate
- CBNumber
- CB41873108
- Molecular Formula
- C10H19NO9
- Formula Weight
- 297.26
- MOL File
- 957230-65-8.mol
Isofagomine D-Tartrate Property
- Melting point:
- 124-126°C
- storage temp.
- -20°C Freezer, Under Inert Atmosphere
- solubility
- Soluble in DMSO (up to 2 mg/ml)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H350May cause cancer
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P308+P313IF exposed or concerned: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16137
- Product name
- Isofagomine (D-tartrate)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 16137
- Product name
- Isofagomine (D-tartrate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $202
- Updated
- 2024/03/01
- Product number
- 16137
- Product name
- Isofagomine (D-tartrate)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $364
- Updated
- 2024/03/01
- Product number
- 293800
- Product name
- Isofagomine D-tartrate
- Packaging
- 5mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- I816010
- Product name
- IsofagomineD-Tartrate
- Packaging
- 5mg
- Price
- $180
- Updated
- 2021/12/16
Isofagomine D-Tartrate Chemical Properties,Usage,Production
Description
Isofagomine tartrate (957230-65-8) is a competitive inhibitor of human lysosomal β-glucosidase, IC50?= 0.06 μM.1?Increases the activity of N370S mutant acid β-glucosidase (GlcCerase) in Gaucher fibroblasts.2?Displays a direct pharmacological chaperone effect greatly increasing the amount of newly synthesized GlcCerase that traffics out of the ER.2
Chemical Properties
Isofagomine D-Tartrate is Off-White Solid
Uses
Isofagomine D-Tartrate is used as human acid ?glucosidase inhibitor and for the treatment of Gaucher disease
Uses
Used as human acid β-glucosidase inhibitor and for the treatment of Gaucher disease.
References
1) Kuriyama?et al.?(2008),?In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell culture; Bioorg. Med. Chem.,?16?7330 2) Steet?et al. (2006),?The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms; Proc. Natl. Acad. Sci. USA,?103?13813
Isofagomine D-Tartrate Preparation Products And Raw materials
Raw materials
Preparation Products
Isofagomine D-Tartrate Suppliers
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