ChemicalBook > CAS DataBase List > Fmoc-N-methyl-L-phenylalanine

Fmoc-N-methyl-L-phenylalanine

Product Name: Fmoc-N-methyl-L-phenylalanine
CAS No.: 77128-73-5
Chemical Name: Fmoc-N-methyl-L-phenylalanine
Synonyms: FMOC-MEPHE-OH;FMOC-L-MEPHE-OH;FMOC-N-ME-PHE-OH;FMOC-N-ME-L-PHE-OH;FMOC-N-ME-PHE 98.5+%;FMOC-N-ME-PHENYLALANINE;Fmoc-N-Me-Phe-OH;Fmoc-N-mety)-L-phenylalanine;FMOC-N-METHYL-L-PHENYLALANINE;Fmoc-N-α-methyl-L-Phenylalanine
CBNumber: CB4197124
Molecular Formula: C25H23NO4
Formula Weight: 401.45
MOL File: 77128-73-5.mol

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Fmoc-N-methyl-L-phenylalanine Property

Melting point:: 132.0 to 136.0 °C
Boiling point:: 595.4±39.0 °C(Predicted)
Density: 1.260±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMF. (0.3gram in 2ml)
pka: 3.78±0.10(Predicted)
form: Powder
color: Off-white
optical activity: [α]20/D 55.0±3°, c = 1% in DMF
BRN: 4768138
InChI: InChI=1S/C25H23NO4/c1-26(23(24(27)28)15-17-9-3-2-4-10-17)25(29)30-16-22-20-13-7-5-11-18(20)19-12-6-8-14-21(19)22/h2-14,22-23H,15-16H2,1H3,(H,27,28)/t23-/m0/s1
InChIKey: GBROUWPNYVBLFO-QHCPKHFHSA-N
SMILES: C(O)(=O)[C@H](CC1=CC=CC=C1)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C
CAS DataBase Reference: 77128-73-5(CAS DataBase Reference)

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 2924 29 70
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.52137
Product name: Fmoc-N-Me-Phe-OH
Purity: Novabiochem?
Packaging: 1g
Price: $118
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.52137
Product name: Fmoc-N-Me-Phe-OH
Purity: Novabiochem?
Packaging: 5G
Price: $473
Updated: 2025/07/31

TCI Chemical

Product number: F1167
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $40
Updated: 2025/07/31

TCI Chemical

Product number: F1167
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $121
Updated: 2025/07/31

TRC

Product number: F641508
Product name: Fmoc-mephe-oh
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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Fmoc-N-methyl-L-phenylalanine Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

N-Fmoc-N-methyl-L-phenylalanine is used in agrochemical, pharmaceutical and dyestuff field.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

84000-03-3

77128-73-5

Fmoc-phenylalanyl oxazolidinone (4.60 g, 11.6 mmol) was dissolved in chloroform (58 mL). To this solution, trifluoroacetic acid (2.68 mL, 34.8 equiv) and triethylsilane (5.56 mL, 34.8 equiv) were added sequentially. The reaction mixture was stirred at room temperature until the reaction was complete (24-72 hours). Upon completion of the reaction, the solution was concentrated and subsequently partitioned between ether and saturated sodium bicarbonate solution. The aqueous phase was combined, acidified to pH 2 with 5 M hydrochloric acid and extracted with ethyl acetate. The organic phase was collected, dried with anhydrous magnesium sulfate and concentrated to give a dark yellow oily product. The crude product was dissolved in dichloromethane and repeatedly evaporated to yield Fmoc-N-methylphenylalanine as a brown solid (3.73 g, 80% yield): melting point 106-107 °C; low-resolution mass spectrometry (ESI) m/z [M + H]+ 402.1 (100%); 1H NMR (300 MHz, CDCl3) δH (ppm) (rotated isomer ) 7.74 (2H, d, J = 7.5 Hz, ArH), 7.49 (1H, d, J = 7.8 Hz, ArH), 7.43 (1H, t, J = 6.9 Hz, ArH), 7.37 (2H, t, J = 7.5 Hz, ArH), 7.25-7.21 (6H, m, ArH), 6.95 (1H, d, J = 6.3 Hz , ArH), 4.89 (1H, dd, J = 5.1, 11.1 Hz, NCHCOOH), 4.59-4.53 (1H, m, (Ar)2CHCH2), 4.38 (2H, d, J = 14.4 Hz, CHCH2O), 3.41-3.35 (1H, m, CHCHHAr), 3.16-3.08 (1H m, CHCHHAr), 2.77 (3H, s, NCH3), 2.75 (3H, s, NCH3) (1H NMR data are consistent with literature reports); 13C NMR (75 MHz, CDCl3) δC (ppm) 175.5, 156.5, 143.4, 140.9, 136.4, 128.4, 128.3, 127.3, 126.7, 126.5, 124.6, 124.3, 119.6, 67.6, 60.7, 46.7, 34.3, 32.3.

IC 50

Plasmodium

References

[1] Journal of Organic Chemistry, 2005, vol. 70, # 17, p. 6918 - 6920
[2] European Journal of Organic Chemistry, 2013, # 21, p. 4509 - 4513
[3] Tetrahedron, 2014, vol. 70, # 14, p. 2351 - 2358
[4] Tetrahedron Letters, 2006, vol. 47, # 11, p. 1691 - 1694
[5] Angewandte Chemie - International Edition, 2008, vol. 47, # 14, p. 2595 - 2599

Fmoc-N-methyl-L-phenylalanine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Fmoc-N-methyl-L-phenylalanine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: Fmoc-N-methyl-L-phenylalanine 77128-73-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 2000
Release date: 2025-04-22

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-N-Me-L-Phe-OH 77128-73-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-04-13

Shanghai Getian Industrial Co., LTD

Product: Fmoc-N-methyl-L-phenylalanine 77128-73-5
Price: US $23.00-19.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 100000box
Release date: 2024-05-14

77128-73-5, Fmoc-N-methyl-L-phenylalanineRelated Search:

Methyl acrylate Tribenuron methyl Fmoc-Aib-OH Basic Violet 1 D-Phenylalanine METSULFURON METHYL Fmoc-Phe-OH Phenprobamate Methyl salicylate Methylparaben N-Methyl-L-alanine 9-Fluorenylmethyl chloroformate Kresoxim-methyl Methanol FMOC-N-METHYL-D-PHENYLALANINE L-Phenylalanine Fmoc-OSu N-(tert-Butoxycarbonyl)sulfamide

FMOC-N-METHYL-L-PHENYLALANINE

FMOC-N-ME-L-PHE-OH

FMOC-N-ME-PHENYLALANINE

FMOC-N-ME-PHE-OH

FMOC-N-ALPHA-METHYL-L-PHENYLALANINE

FMOC-MEPHE-OH

FMOC-L-MEPHE-OH

N-ALPHA-FMOC-N-ALPHA-METHYL-L-PHENYLALANINE

N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-PHENYLALANINE

N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-L-PHENYLALANINE

FMOC-N-ME-PHE 98.5+%

N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-L-phenylalanine

FMOC-N-METHYL-L-PHENYLALANINE LIQUID

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-phenylpropanoic acid

FMoc-MePhe-OH FMoc-N-α-Methyl-L-Phenylalanine

Nα-Fmoc-Nα-Methyl-L-phenylalanine

Fmoc-N-Me-Phe-OH >=99.0% (sum of enantiomers, HPLC)

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-phenylalanine

(9H-Fluoren-9-yl)MethOxy]Carbonyl N-Me-Phe-OH

(2S)-2-[9H-fluoren-9-ylmethoxycarbonyl(methyl)amino]-3-phenylpropanoic acid

Fmoc-<I>N</I>-Me-Phe-OH

Nα-Fmoc-Nα-Methyl-L-phenylalanine≥ 98% (HPLC)

L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-

Fmoc-N-methyl-L-phenylalanine USP/EP/BP

Fmoc-N-α-methyl-L-Phenylalanine

Fmoc-N-mety)-L-phenylalanine

Fmoc-N-Me-Phe-OH, 10 mM in DMSO

N-Fmoc-N-methyl-L-phenylalanine

77128-73-5

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