ChemicalBook > CAS DataBase List > tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate

Product Name
tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
CAS No.
289042-12-2
Chemical Name
tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Synonyms
R1 ROSUVASTATIN;(4R,6S)-6-[(1E)-2-[4-(4-FLUOROPHENYL)-6-(1-METHYLETHYL)-2-[METHYL(METHYLSULFONYL)AMINO]-5-PYRIMIDINYL]ETHENYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID, 1,1-DIMETHYLETHYL ESTER;Rosuvastatin R1;tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)vinyl)-2,2-diMethyl-1,3-dioxan-4-yl)acetate;6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester;Rosuvastatin intermediate R-2;tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetat;Rosuvastatin BEM;R-1 interMediate;RSV Intermediate
CBNumber
CB4200581
Molecular Formula
C29H40FN3O6S
Formula Weight
577.71
MOL File
289042-12-2.mol
More
Less

tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate Property

Melting point:
153-155°C
Boiling point:
673.3±65.0 °C(Predicted)
Density 
1.210
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
-0.43±0.10(Predicted)
form 
Solid
color 
White to Off-White
InChIKey
WIFPCEOJTKZGSA-UQECUQMJSA-N
SMILES
O1[C@H](/C=C/C2=C(C(C)C)N=C(N(C)S(C)(=O)=O)N=C2C2=CC=C(F)C=C2)C[C@H](CC(OC(C)(C)C)=O)OC1(C)C
CAS DataBase Reference
289042-12-2(CAS DataBase Reference)
More
Less

Safety

HS Code 
2935909550
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
F595400
Product name
(4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-aceticAcid1,1-DimethylethylEster
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148489
Product name
tert-Butyl6-[(1e)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Packaging
25mg
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148489
Product name
tert-Butyl6-[(1e)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Packaging
100mg
Price
$258
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148489
Product name
tert-Butyl6-[(1e)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Packaging
50mg
Price
$148
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB148489
Product name
tert-Butyl6-[(1e)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
Packaging
250mg
Price
$515
Updated
2021/12/16
More
Less

tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

(4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester (Rosuvastatin EP Impurity F) is a Rosuvastatin (R700500) intermediate as HMG-CoA reductase inhibitor.

tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate Suppliers

Canada 2 China 246 Germany 1 India 17 United Kingdom 3 United States 10 Global 279
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
More
Less

View Lastest Price from tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate manufacturers

Sinoway Industrial co., ltd.
Product
Rosuvastatin Intermediate R1 289042-12-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99% up by HPLC, Single impurity < 0.3%, total impurities < 0.5%
Supply Ability
20tons
Release date
2024-04-16
airuikechemical co., ltd.
Product
r-1 289042-12-2
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-09
Hangzhou ICH Biofarm Co., Ltd
Product
tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate 289042-12-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200
Release date
2023-07-11

289042-12-2, tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetateRelated Search:

VINYL PROPIONATE 4-(4-CHLORO-BENZYLOXY)-PHENYLAMINE Basic Violet 1 1-BUTEN-3-YNE Methanol Triethoxyvinylsilane Paraquat dichloride Methylparaben N-Vinyl-2-pyrrolidone Acetonitrile Methyl acetate Methyl acrylate Kresoxim-methyl tert-Butyl rosuvastatin Pitavastatin Impurity 8 Rosuvastatin Impurity 4 Ethyl propionylacetate Methyl

  • (4R,6S)-6-[(1E)-2-[4-(4-FLUOROPHENYL)-6-(1-METHYLETHYL)-2-[METHYL(METHYLSULFONYL)AMINO]-5-PYRIMIDINYL]ETHENYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID, 1,1-DIMETHYLETHYL ESTER
  • tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
  • 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester
  • Rosuvastatin intermediate R-2
  • Tert-Butyl-(+)7-[4-(4-Fluorophenyl)-6-Isopropyl-2-(N-Methyl-N-Methyl Sulfonylamino)Pyrimidine-5-Yl]-(3r,5s)-Dioxane-(E)-6-Heptena
  • Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(n-methyl,n-methyl sulphonyl amino) pyrimidine-5-yl]-(3r-5s)-dioxane-(e)-6 heptane
  • Tert-butyl –(+)7-[4-(4-fluorophenyl)-6-lsopropyl -2-(N-methylsulfonylamino)-pyrlmidine-5-yl]-(3R,5S)- dioxane-(E)-6-heptenate
  • Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidine-5-yl]-(3R,5S)-dioxane-(E)
  • ERT-BUTYL-(+)7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL-N-METHYL SULFONYLAMINO)PYRIMIDINE-5-YL] -(3R,5S)-DIOXANE-(E)
  • Rosuvastatin calcium-7
  • Rosuvastatin Impurity 28(Rosuvastatin EP Impurity F)
  • Rosuvastatin Calcium EP Impurity F
  • Rosuvastatin Impurity F
  • tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetat
  • Rosuvastatin BEM
  • Rosuvastatin intermediate R-1
  • R-2：Tert-butyl –(+)7-[4-(4-fluorophenyl)-6-lsopropyl -2-(N-methylsulfonylamino)-pyrlmidine-5-yl]-(3R,5S)- dioxane-(E)-6-heptenate
  • (4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid
  • tert-Butyl 6-[(1E)-2
  • (ZD-8-1) tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)aMino]-5-pyriMidinyl]ethenyl]-2,2-diMethyl-1,3-dioxane-4-acetate
  • R-1 interMediate
  • 2-{6-[(E)-2-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]ethenyl]-2,2-diMethyl-1,3-dioxan-4-yl}-3,3-diMethylbutanoate
  • Rosuvastatin Acetonide t-Butyl Ester
  • Rosuvastatin calciuM interMediate R-2
  • Tert-butyl-(+)7-[4-(4-fluorophenyl)-6-isopropyl-2-( N-METHYL- N-MethylsulfonylaMino)pyriMidine-5-yl]-(3R,5S)-dioxane-(E)-6-heptenate
  • tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-MethylMethylsulfonaMido)pyriMidin-5-yl)vinyl)-2,2-diMethyl-1,3-dioxan-4-yl)acetate
  • 3-Dioxane-4-acetic acid,6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)aMino]-5-pyriMidinyl]ethenyl]-2,2-diMethyl-, 1,1-diMethylethyl ester, (4R,6S)-
  • 1,3-Dioxane-4-acetic acid,6- (1E)-2- 4-(4-fluorophenyl)-6-(1-Methylethyl)-2- Methyl(Methylsulfonyl)aMino -5-pyriMidinyl ethenyl -2,2-diMethyl-, 1,1-diMethylethyl ester, (4R,6S)-
  • Rosuvastatin Acetonide
  • R1 ROSUVASTATIN
  • Rosuvastatin EP Impurity F
  • R-1: TERTIARY-BUTYL-(+)-[(4-FLUOROPHENYL)-6-ISOPROPYL-2-(N-METHYL, N-METHYL SULPHONYL AMINO) PYRIMIDINE-5-YL]-(3R-5S)-DIOXANE-(E)-6 HEPTANE
  • 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1 -methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester
  • t-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
  • 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dime
  • 6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2
  • Rosuvastatin Impurity 28
  • tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxa
  • High quality ISO & BV Factory Tert-but...
  • (4R,6S)-6-[(1E)-2-[4-(4-Fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester
  • tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate [R1]
  • 1,1-dimethylethyl [(4R,6S)-6-[(E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)a
  • Rosuvastatin EP Impurity F (Rosuvastatin Acetonide t-Butyl Ester)
  • Tert-butyl-2-((4R,6S)-6-(E)-2-(4-(4-fluorophenyl)-6-Isopropyl-2-(N-methyl-D3-Methylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-Dimethyl-1,3-dioxan-4-yl)acetate
  • tert-Butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2...
  • Rosuvastatin R1
  • ethyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
  • tert-Butyl6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(metChemicalbookhylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
  • Rosuvastatin Related Compound C
  • 1,1-Dimethylethyl(4R,6S)-6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
  • Rosuvastatin USP Related Compound C
  • R-1: Tert-Butyl6-[(1E)-2-[4-(4- fluorophenyl)-6-(1-methylethyl)-2- [methyl(methylsulfonyl) amino]-5- pyrimidinyl]ethenyl]-2,2-dimethyl-1,3- dioxane-4-acetate
  • (4R,6S,1E)-tert-Butyl 6-[2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate
  • Rosuvastatin Acetonide tertButyl Ester
  • Tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-flurophenyl)-6-isopropyl-2-(N- methylmethane sulfonamidoPyrimidin - 5-yl)vinyl)-2,2-dimethyl-1,3-dioxane-4-yl-)acetate (TIN)
  • Tertbutyl (E)-(6-{2-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methyl sulfonyl)amino pyrimidin-5-yl]vinyl}(4R,5R)-2,2-dimethyl[1,3]dioxane-4-yl)acetate
  • RSV Intermediate
  • tert-butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2- (N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl- 1,3-dioxan-4-yl)aceta