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Isochlorogenic acid C

Product Name
Isochlorogenic acid C
CAS No.
57378-72-0
Chemical Name
Isochlorogenic acid C
Synonyms
4,5-Dicaffeoylquinic acid;3,4-O-Dicaffeoylquinic acid;Isochlorogenic acid C;Isochlorogenic acid C(4,5');3,4-Dicaffeoylquinic acid-RM;4,5-Dicaffeoylquinic acid, >99%;Isochlorogenic acid C USP/EP/BP;Isochlorogenic acid C in Methanol;3,4-Dicaffeoylquinic acid|||Isochlorogenic acid C;1β,5α-Dihydroxy-3β,4β-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecarboxylic acid
CBNumber
CB42201548
Molecular Formula
C25H24O12
Formula Weight
516.45
MOL File
57378-72-0.mol
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Isochlorogenic acid C Property

Boiling point:
810.8±65.0 °C(Predicted)
Density 
1?+-.0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 5 mg/ml
form 
A solid
pka
3.70±0.50(Predicted)
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00221
Product name
4,5-Di-O-caffeoylquinic acid
Purity
≥85% (LC/MS-ELSD)
Packaging
1mg
Price
$459
Updated
2024/03/01
Cayman Chemical
Product number
27892
Product name
4,5-Dicaffeoylquinic Acid
Packaging
25mg
Price
$667
Updated
2024/03/01
Cayman Chemical
Product number
27892
Product name
4,5-Dicaffeoylquinic Acid
Packaging
50mg
Price
$1175
Updated
2024/03/01
Cayman Chemical
Product number
27892
Product name
4,5-Dicaffeoylquinic Acid
Packaging
5mg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
27892
Product name
4,5-Dicaffeoylquinic Acid
Packaging
10mg
Price
$299
Updated
2024/03/01
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Isochlorogenic acid C Chemical Properties,Usage,Production

Description

4,5-Dicaffeoylquinic acid (4,5-DCQA) is a polyphenol originally isolated from G. fagetorum and G. pseudomollugo that has diverse biological activities, including anti-HIV replication, antioxidative, anti-inflammatory, and anti-melanogenic properties. It inhibits HIV-1 integrase 3'' end processing, 3’ end joining, and disintegration with IC50 values of 0.13, 0.24, and 0.3 μg/ml, respectively. It also inhibits HIV-1 replication in MT-2 T lymphoblastoid cells with an EC50 value of 2 μg/ml. 4,5-DCQA scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals in a cell-free assay (IC50 = 19.8 μM) and inhibits superoxide production in human neutrophils activated by N-formyl-Met-Leu-Phe (fMLF; ) and cytochalasin B (; IC50 = 1.49 μM). It decreases prostaglandin E2 (PGE2; ) production in LPS-stimulated U937 cells when used at concentrations of 5 and 10 μg/ml but increases it when used at 200 μg/ml and increases production of TNF-α at concentrations ranging from 5 to 200 μg/ml. It inhibits the synthesis of MCP3 in U937 cells. 4,5-DCQA (25 μM) inhibits melanogenesis by 84% and decreases the levels of proteins involved in melanin biosynthesis, including tyrosinase, TRP-1, DCT, and MITF in B16F1 murine melanocytes.

Uses

4,5-Dicaffeoylquinic Acid is a selective inhibitor of human immunodeficiency virus type 1 integrase.

Definition

ChEBI: 4,5-di-O-caffeoylquinic acid is a quinic acid.

Isochlorogenic acid C Preparation Products And Raw materials

Raw materials

Preparation Products

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Isochlorogenic acid C Suppliers

China 137 Germany 1 India 2 United Kingdom 1 United States 17 Global 158
Ria International India Private Limited
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Country
India
ProdList
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Advantage
58
A.J Chemicals
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from Isochlorogenic acid C manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Isochlorogenic acid C 57378-72-0
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-27

57378-72-0, Isochlorogenic acid CRelated Search:

Isochlorogenic acid C BAVACHININ A epiberberine Isochlorogenic Acid B glaucocalyxin A Taxifolin Isochlorogenic acid A Isoastilbin Fluorescein isothiocyanate Isocitric acid trisodium salt (E,E)-3,5-Di-O-caffeoylquinic acid CAFTARIC ACID Cryptochlorogenic acid Chlorogenic acid CYNARIN 1,3,5-Tricaffeoylquinic acid 1-Caffeoylquinic acid 2,3,4,5-Tetracaffeoyl-D-Glucaric acid

  • Isochlorogenic acid C
  • (1R)-1,3β-Dihydroxy-4α,5α-bis[3-(3,4-dihydroxyphenyl)acryloyloxy]-1β-cyclohexanecarboxylic acid
  • (1R,3R,4S,5R)-1,5-Dihydroxy-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1-cyclohexanecarboxylic acid
  • 1β,5α-Dihydroxy-3β,4β-bis[3-(3,4-dihydroxyphenyl)propenoyloxy]cyclohexanecarboxylic acid
  • 3,4-O-Dicaffeoylquinic acid
  • Isochlorogenic acid C(4,5')
  • 4,5-Dicaffeoylquinic acid
  • 4,5-Dicaffeoylquinic acid, >99%
  • Cyclohexanecarboxylic acid, 3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-1,5-dihydroxy-, (1R,3R,4S,5R)-
  • (1R,3R,4S,5R)-3,4-Bis((3-(3,4-dihydroxyphenyl)acryloyl)oxy)-1,5-dihydroxycyclohexanecarboxylic acid
  • (1R,3R,4S,5R)-1,5-Dihydroxy-3,4-bis[[3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]oxy]-1-cyclohexanecarboxylicaci
  • Isochlorogenic acid C USP/EP/BP
  • 3,4-Dicaffeoylquinic acid|||Isochlorogenic acid C
  • 3,4-Dicaffeoylquinic acid-RM
  • Isochlorogenic acid C in Methanol
  • 57378-72-0