N-(Chloromethyl)phthalimide

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N-(Chloromethyl)phthalimide

Product Name: N-(Chloromethyl)phthalimide
CAS No.: 17564-64-6
Chemical Name: N-(Chloromethyl)phthalimide
Synonyms: AKOS BBS-00000871;TIMTEC-BB SBB000346;Chloromethylphthalimide;N-(CHLOROMETHYL)PHTHALIMIDE;N-Chloromethyltrimellitimide;Phthalimide, N-(chloromethyl)-;N-(Chloromethyl)phthalimide,97%;N-(Chloromethyl)phthalimide 97%;N-(Chloromethyl)phthalimide, 98+%;2-(Chloromethyl)isoindole-1,3-dione
CBNumber: CB4220350
Molecular Formula: C9H6ClNO2
Formula Weight: 195.6
MOL File: 17564-64-6.mol

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N-(Chloromethyl)phthalimide Property

Melting point:: 131-135 °C (lit.)
Boiling point:: 305.2±25.0 °C(Predicted)
Density: 1.3228 (rough estimate)
refractive index: 1.5790 (estimate)
storage temp.: 2-8°C
solubility: chloroform: soluble50mg/mL
form: powder to crystal
pka: -2.63±0.20(Predicted)
color: White to Almost white
Water Solubility: slightly soluble
BRN: 140942
InChI: InChI=1S/C9H6ClNO2/c10-5-11-8(12)6-3-1-2-4-7(6)9(11)13/h1-4H,5H2
InChIKey: JKGLRGGCGUQNEX-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2)C(=O)N1CCl
CAS DataBase Reference: 17564-64-6(CAS DataBase Reference)
NIST Chemistry Reference: N-(chloromethyl)phthalimide(17564-64-6)
EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-(chloromethyl)- (17564-64-6)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-52/53-43-22
Safety Statements: 26-36-37/39-61-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
F: 9-21
TSCA: Yes
HS Code: 29251995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 232424
Product name: N-(Chloromethyl)phthalimide
Purity: 97%
Packaging: 10g
Price: $105
Updated: 2024/03/01

Sigma-Aldrich

Product number: 232424
Product name: N-(Chloromethyl)phthalimide
Purity: 97%
Packaging: 50g
Price: $369
Updated: 2024/03/01

TCI Chemical

Product number: A5504
Product name: N-Chloromethylphthalimide [for HPLC Labeling]
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $131
Updated: 2024/03/01

Alfa Aesar

Product number: A12018
Product name: N-(Chloromethyl)phthalimide, 97%
Packaging: 25g
Price: $66.65
Updated: 2024/03/01

Alfa Aesar

Product number: A12018
Product name: N-(Chloromethyl)phthalimide, 97%
Packaging: 100g
Price: $274
Updated: 2024/03/01

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N-(Chloromethyl)phthalimide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

N-(Chloromethyl)phthalimide is used as an agrochemical and medicine intermediates and is used in organic synthesis. Microporous membranes prepared from chemically modified polysulfone, which is a derivative of this compound have better streaming potential.

Application

N-(Chloromethyl)phthalimide is a chlorine derivative of Phthalimide. Phthalimide and its derivatives are essential compounds in diverse fields. In pharmaceuticals, they are used as an intermediate material. In the medical field, they are used to synthesize compounds with antimicrobial activity, androgens, and other agents for treating tumor necrosis factor. Certain phthalimide derivatives are used as herbicides and to reduce bacterial contamination. They are widely used in industries to produce pesticides, plastics, resins, and surfactants. The N-substitution of the Phthalimide has a hypsochromic effect on color change and better color yields on poly fabrics because of the electron-donating property of the methyl group and the higher hydrophobicity of Phthalimide. Its chlorine derivative is used as an intermediate for producing medicine, pharmacy, dyes, pesticides, fire retardants, and photocopying chemicals. In particular, N-(bromomethyl)phthalimide and N-(chloromethyl)phthalimide play a vital role in anti-inflammatory, analgesic, and hypolipidimic activities[1].

Purification Methods

Purify the imide by recrystallisation from EtOAc or CCl4 or via the 1:1 complex with pyridine [Sakellarios J Am Chem Soc 70 2822 1948, B.hme et al. Chem Ber 92 1258 1959]. [Beilstein 21/10 V 372.]

References

[1] V. Balachandran , S. Rajeswari, S. Lalitha . “Density functional theory, comparative vibrational spectroscopic studies, NBO, HOMO–LUMO analyses and thermodynamic functions of N-(bromomethyl)phthalimide and N-(chloromethyl)phthalimide.” Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 91 (2012): Pages 146-157.

N-(Chloromethyl)phthalimide Preparation Products And Raw materials

Raw materials

Phthalimide Toluene

Preparation Products

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View Lastest Price from N-(Chloromethyl)phthalimide manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: N-(Chloromethyl)phthalimide 17564-64-6
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-07-30

Career Henan Chemical Co

Product: N-(Chloromethyl)phthalimide 17564-64-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 200kg
Release date: 2019-08-30

17564-64-6, N-(Chloromethyl)phthalimideRelated Search:

Maleimide Potassium phthalimide O-Phthalimide Phthalhydrazide 4-Nitrophthalimide 4-Aminophthalimide Succinimide N-Hydroxyphthalimide Bismaleimide N-Methylphthalimide 3-Nitrophthalimide Chloromethyl methyl ether DIALIFOS Benzylamine hydrochloride N,N-Dimethylbenzamide Diethylamine hydrochloride 2-METHYLISOINDOLIN-1-ONE N-CHLOROMETHYL-4-NITROPHTHALIMIDE

AKOS BBS-00000871

2-(CHLOROMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE

TIMTEC-BB SBB000346

N-(CHLOROMETHYL)PHTHALIMIDE

1H-Isoindole-1,3(2H)-dione, 2-(chloromethyl)-

2-(chloromethyl)-1h-isoindole-3(2h)-dione

Chloromethylphthalimide

N-Chloromethyltrimellitimide

Phthalimide, N-(chloromethyl)-

N-Chloromethylphthalimide [for HPLC Labeling]

1-[(2R,4S,5S)-5-(fluoromethyl)-4-hydroxy-2-oxolanyl]-5-methylpyrimidine-2,4-dione

2-(ChloroMethyl)isoindoline-1,3-dione

N-(Chloromethyl)phthalimide, 98+%

2-(Chloromethyl)isoindole-1,3-dione

2-(Chloromethyl)-2H-isoindole-1,3-dione

N-(Chloromethyl)phthalimide,97%

N-(Chloromethyl)-1H-Isoindole-1,3(2H)-dione

N-(Chloromethyl)phthalimide 97%

2-(Chloromethyl)-1H-isoindol-1,3(2H)-dione

2-(2-Chloromethyl)-1H-isoindole-1,3(2H)-dione

N-(Chloromethyl)phthalimide≥ 98% (HPLC)

N-Chloromethylphthalimide [for HPLC Labeling]&gt

17564-64-6

N-Substituted Phthalimides

N-Substituted Maleimides, Succinimides & Phthalimides

UV Detection (HPLC Labeling Reagents)

HPLC Labeling Reagents

Carboxyl Group Labeling Reagents for HPLC

Cyclic Imides

Organic Building Blocks

Building Blocks

Carbonyl Compounds

API Intermediate

Carbonyl Compounds

Cyclic Imides

Organic Building Blocks

N-Substituted Maleimides, Succinimides & Phthalimides

N-Substituted Phthalimides

UV Detection (HPLC Labeling Reagents)

Analytical Chemistry

Carboxyl Group Labeling Reagents for HPLC

HPLC Labeling Reagents