ChemicalBook > CAS DataBase List > (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

Product Name: (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
CAS No.: 140148-70-5
Chemical Name: (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid
Synonyms: (S)-1-N-BOC-BETA-PROLINE;N-Boc-L-beta-p;BOC-L-B-PROLINE;(3S)-Boc-β-Pro-OH;(3S)-BOC-BETA-PRO-OH;N-Boc-L-beta-proline;1-N-Boc-delta-Proline;N-Boc-L-^b-proline,95%;N-Boc-L-^b-proline, 95%;(3S)-Boc-β-Pro-OH
CBNumber: CB4225931
Molecular Formula: C10H17NO4
Formula Weight: 215.25
MOL File: 140148-70-5.mol

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(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Property

Melting point:: 140-145°C
Boiling point:: 337.2±35.0 °C(Predicted)
Density: 1.201±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.47±0.20(Predicted)
form: solid
Appearance: White to off-white Solid
optical activity: [α]/D +15.0°, c = 0.5% in chloroform
Water Solubility: Soluble in water (slightly).
InChI: InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-5-4-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m0/s1
InChIKey: HRMRQBJUFWFQLX-ZETCQYMHSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC[C@H](C(O)=O)C1
CAS DataBase Reference: 140148-70-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N
Risk Statements: 41-50
Safety Statements: 26-39-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS005246
Product name: (3S)-Boc-β-Pro-OH
Purity: Aldrich
Packaging: 100mg
Price: $73.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 735507
Product name: (S)-1-Boc-3-pyrrolidinecarboxylic acid
Purity: 97%
Packaging: 500mg
Price: $108.68
Updated: 2025/07/31

TRC

Product number: B661975
Product name: (S)-1-Boc-Pyrrolidine-3-carboxylicAcid
Packaging: 2.5g
Price: $45
Updated: 2021/12/16

Usbiological

Product number: 261906
Product name: N-Boc-D-proline
Packaging: 25g
Price: $330
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56181
Product name: Boc-(3S)-1-pyrrolidine-3-carboxylic acid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

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(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

N-Boc-L-beta-proline is an important raw material and intermediate used in pharmaceuticals, agrochemicals and dyestuff.

Synthesis

122684-33-7

72925-16-7

General procedure for the synthesis of (R)-1-Boc-3-carboxypyrrolidine from methyl 1-Boc-pyrrolidine-3-carboxylate: sodium hydroxide (0.80 g, 20.00 mmol) was dissolved in water (15 mL), and this solution was added to a methanol (30 mL) solution of methyl 1-Boc-pyrrolidine-3-carboxylate (2.30 g, 10.00 mmol). . The reaction mixture was allowed to react for 3 hours with stirring at room temperature. After the reaction was completed, the methanol was removed by concentration under reduced pressure. The pH of the remaining aqueous solution was adjusted to 4 with 2 M glacial acetic acid and then extracted with dichloromethane (50 mL x 3). The organic phases were combined and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 1.80 g of an oily product in 83.00% yield.

References

[1] Organic Letters, 2005, vol. 7, # 15, p. 3287 - 3289
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[3] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[4] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0453; 0454; 0455
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059

(3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid manufacturers

Honest Joy Holdings Limited

Product: (S)-1-Boc-pyrrolidine-3-carboxylic acid 140148-70-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 100 tons
Release date: 2022-01-26

Career Henan Chemical Co

Product: (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid 140148-70-5
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

140148-70-5, (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acidRelated Search:

(2R,4R)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate 2-(N,N-DIMETHYLAMINOMETHYL)PHENYLBORONIC ACID Ethyl 1-Boc-3-pyrrolidinecarboxylate (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid BOC-D-PROLINE HYDROXYSUCCINIMIDE ESTER,BOC-D-PROLINE-OSU,BOC-D-PROLINE N-HYDROXYSUCCINIMIDE ESTER,BOC-D-PROLINE HYDROXYSUCCINIMIDESTER (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-carboxylic acid N-Boc-D-proline,N-BOC-D-PROLINE-OH,BOC-D-PROLINE,BOC-D-PROLINE-OH,N-Boc-D-proline, 98+%,BOC-D-PROLINE extrapure BOC-DL-PROLINE,N-BOC-DL-PROLINE 1-N-BOC-BELTA-PROLINE,1-N-BOC-BETA-PROLINE (4S)-4-N-FMOC-AMINO-1-BOC-L-PROLINE Methyl 1-Boc-3-pyrrolidinecarboxylate BOC-L-Proline BOC-DL-PROLINE ETHYL ESTER BOC-L-PROLINE HYDROXYSUCCINIMIDESTER,N-Boc-L-Proline succinimidyl ester L-N-[(4&#39-Boc)piperidino]proline (R)-1-N-Boc-beta-proline 3-Pyrrolidinecarboxylic acid 1-Boc-Pyrrolidine

(S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

(3S)-Boc-β-Pro-OH

1,3-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3S)-

(3S)-1-Boc-3-pyrrolidinecarboxylic acid

N-Boc-L-beta-proline

(S)-3-Carboxypyrrolidine-1-carboxylic acidtert-butyl ester

BOC-L-B-PROLINE

BOC-(3S)-1-PYRROLIDINE-3-CARBOXYLIC ACID

(3S)-BOC-1-PYRROLIDINE-3-CARBOXYLIC ACID

(3S)-BOC-BETA-PRO-OH

(3s)-1-(tert-butoxycarbonyl)-3-pyrrolidinecarboxylic acid

(S)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

(S)-N-BOC-PYRROLIDINE-3-CARBOXYLIC ACID

S-1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID

(S)-1-N-BOC-BETA-PROLINE

1-N-Boc-pyrrolidine-3(S)-carboxylic acid

1-N-Boc-delta-Proline

(3S)-1-(tertbutoxycarbonyl)pyrrolidine-3-carboxylic acid

(S)-1-N-BOC-PYRROLIDINE-3-CARBOXYLICACID

R-1-BOC-3-PYRROLIDINECARBOXYLIC ACID

1-N-boc-3-pyrrolidinecarboxylate

1-(TERT-BUTOXYCARBONYL)-3-PYRROLIDINECARBOXYLIC ACID

N-Boc-L-^b-proline, 95%

(S)-1-Boc-3-pyrrolidinecarboxylic Acid

N-Boc-S-3-Pyrrolidinecarboxylic acid

N-Boc-L-beta-p

(S)-1-Boc-3-carboxylic'acid'pyrrolidine

N-Boc-L-^b-proline,95%

140148-70-5 C10H17NO4 (3S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

(3S)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid

1-Propanol,3-[(tetrahydro-2H-pyran-5-yl)oxy]-

1-(1,1-Dimethylethyl) (3S)-1,3-pyrrolidinedicarboxylate

(S)-1-Boc-pyrrolidine-3-carboxylic acid?New

(<i>S</i>)-1-Boc-3-pyrrolidinecarboxylic acid

(3<i>S</i>)-Boc-β-Pro-OH

1-(tert-Butyl) (3S)-1,3-pyrrolidinedicarboxylate

140148-70-5

pharmacetical

Pyrrole&Pyrrolidine&Pyrroline