(R)-1-N-Boc-beta-proline

Product Name: (R)-1-N-Boc-beta-proline
CAS No.: 72925-16-7
Chemical Name: (R)-1-N-Boc-beta-proline
Synonyms: B67255;BOC-L-B-PROLINE;Boc-D-beta-Proline;(3S)-BOC-BETA-PRO-OH;N-Boc-D-beta-proline;(R)-N-Boc-Beta-Proline;N-Boc-D-^b-proline, 95%;(R)-1-N-Boc-beta-proline;(S)-1-N-BOC-BETA-PROLINE;R-Boc-Pyrrolidine-3-carboxylic
CBNumber: CB7225932
Molecular Formula: C10H17NO4
Formula Weight: 215.25
MOL File: 72925-16-7.mol

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(R)-1-N-Boc-beta-proline Property

Melting point:: 138-143°C
Boiling point:: 337.2±35.0 °C(Predicted)
Density: 1.201±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in Dimethyl sulfoxide (DMSO).
form: solid
pka: 4.47±0.20(Predicted)
color: White to off-white
optical activity: [α]/D -15.0, c = 0.5% in chloroform
InChI: InChI=1S/C10H17NO4/c1-10(2,3)15-9(14)11-5-4-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m1/s1
InChIKey: HRMRQBJUFWFQLX-SSDOTTSWSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC[C@@H](C(O)=O)C1
CAS DataBase Reference: 72925-16-7(CAS DataBase Reference)

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Safety

Hazard Codes: N
Risk Statements: 36/37/38-50
Safety Statements: 26-36/37/39-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 735493
Product name: (R)-1-Boc-3-pyrrolidinecarboxylic acid
Purity: 97%
Packaging: 500mg
Price: $113.97
Updated: 2025/07/31

TRC

Product number: B809535
Product name: (R)-1-(tert-Butoxycarbonyl)pyrrolidine-3-carboxylicAcid
Packaging: 500mg
Price: $65
Updated: 2021/12/16

AK Scientific

Product number: S922
Product name: (R)-1-Boc-3-carboxylpyrrolidine
Packaging: 250mg
Price: $26
Updated: 2021/12/16

ChemScene

Product number: CS-B0422
Product name: (R)-1-N-Boc-beta-proline
Purity: ≥97.0%
Packaging: 1g
Price: $38
Updated: 2021/12/16

AK Scientific

Product number: J93496
Product name: (R)-1-Boc-3-carboxylpyrrolidine
Packaging: 1g
Price: $49
Updated: 2021/12/16

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(R)-1-N-Boc-beta-proline Chemical Properties,Usage,Production

Uses

It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Synthesis

122684-33-7

72925-16-7

General procedure for the synthesis of (R)-1-Boc-3-carboxypyrrolidine from methyl 1-Boc-pyrrolidine-3-carboxylate: sodium hydroxide (0.80 g, 20.00 mmol) was dissolved in water (15 mL), and this solution was added to a methanol (30 mL) solution of methyl 1-Boc-pyrrolidine-3-carboxylate (2.30 g, 10.00 mmol). . The reaction mixture was allowed to react for 3 hours with stirring at room temperature. After the reaction was completed, the methanol was removed by concentration under reduced pressure. The pH of the remaining solution was adjusted to 4 with 2 M glacial acetic acid and then extracted with dichloromethane (50 mL x 3). The organic phases were combined and dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give 1.80 g of an oily product in 83.00% yield.

References

[1] Organic Letters, 2005, vol. 7, # 15, p. 3287 - 3289
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 1, p. 94 - 104
[3] European Journal of Organic Chemistry, 2005, # 4, p. 673 - 682
[4] Patent: CN106336413, 2017, A. Location in patent: Paragraph 0453; 0454; 0455
[5] Journal of Medicinal Chemistry, 1990, vol. 33, # 7, p. 2052 - 2059

(R)-1-N-Boc-beta-proline Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-N-Boc-beta-proline Suppliers

China 156 Europe 1 France 2 Germany 4 India 3 United Kingdom 3 United States 29 Global 198

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72925-16-7, (R)-1-N-Boc-beta-prolineRelated Search:

(S)-1-N-BOC-BETA-PROLINE 1-(tert-Butoxycarbonyl)-3-pyrrolidinol (R)-1-Boc-3-Hydroxypiperidine BOC-1,3-CIS-ACHC-OH CYCLOHEXANECARBOXYLIC ACID, 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, (1R,3S)- (1R,2S,3R,4R)-2,3-DIHYDROXY-4-(HYDROXYMETHYL)-1-AMINOCYCLOPENTANE HYDROCHLORIDE (R)-1-N-BOC-BETA-PROLINE 1-Boc-Pyrrolidine (R)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester (S)-1-Boc-pyrrolidine-3-carboxylic acid methyl ester R/S-1-N-BOC-BETA-PROLINE 1-N-BOC-BETA-PROLINE

(S)-1-N-BOC-BETA-PROLINE

S-1-BOC-PYRROLIDINE-3-CARBOXYLIC ACID

(S)-PYRROLIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER

BOC-L-B-PROLINE

BOC-(3S)-1-PYRROLIDINE-3-CARBOXYLIC ACID

(3S)-BOC-1-PYRROLIDINE-3-CARBOXYLIC ACID

(3S)-BOC-BETA-PRO-OH

(3R)-1-(tertbutoxycarbonyl)pyrrolidine-3-carboxylic acid

(R)-1-N-BOC-PYRROLIDINE-3-CARBOXYLICACID

(R)-1-Boc-pyrrolidine-3-carboxylic acid

(R)-1-N-Boc-beta-proline

(R)-1-tert-Butoxycarbonyl-pyrrolidine-3-carboxylic acid

(S)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

B67255

R-Boc-Pyrrolidine-3-carboxylic

N-Boc-D-beta-proline

N-Boc-R-3-Pyrrolidinecarboxylic acid

(R)-N-Boc-Beta-Proline

(3R)-1,3-Pyrrolidinedicarboxylic acid 1-(tert-butyl) ester

N-Boc-D-^b-proline, 95%

(R)-1-(t-butoxycarbonyl)-3-pyrrolidinocarboxylic acid

(R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinecarboxylic acid

1,3-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (3R)-

(3R)-1-Boc-3-pyrrolidinecarboxylic acid

1-N-Boc-pyrrolidine-3(R)-carboxylic acid

(R)-1-Boc-3-Carboxyl pyrrolidine

(3R)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid

Boc-D-beta-Proline

1-(1,1-Dimethylethyl) (3R)-1,3-pyrrolidinedicarboxylate

Boc(R)-1-Boc-3-pyrrolidinecarboxylic acid

(R)-1-N-Boc-beta-proline, CAS 72925-16-7

Boc-(3R)-1-pyrrolidine-3-carboxylic acid

1-(tert-Butyl) (3R)-1,3-pyrrolidinedicarboxylate

72925-16-7

pharmacetical

Pyrrole&Pyrrolidine&Pyrroline