Tetrazole
Description References- Product Name
- Tetrazole
- CAS No.
- 288-94-8
- Chemical Name
- Tetrazole
- Synonyms
- 1H-TETRAZOLE;2H-TETRAZOLE;1H-1,2,3,4-TETRAAZOLE;TETRAZOLE;1tetrazole;1H-Tetraazole;Tetrazole,98%;1H tetrazolium;1H-Tetrazole,99+%;1,2,3,4-tetrazole
- CBNumber
- CB4230898
- Molecular Formula
- CH2N4
- Formula Weight
- 70.05
- MOL File
- 288-94-8.mol
Tetrazole Property
- Melting point:
- 156-158°C
- Boiling point:
- 220℃
- Density
- 0.798 g/mL at 20 °C
- refractive index
- n20/D 1.348
- RTECS
- UW7370000
- Flash point:
- 5 °C
- storage temp.
- Room temperature.
- solubility
- DMSO, Methanol
- form
- Liquid
- pka
- 4.9(at 25℃)
- color
- Cream to orange
- Water Solubility
- Soluble
- Decomposition
- 220°C
- BRN
- 105799
- Stability:
- Stable at RT
- InChIKey
- KJUGUADJHNHALS-UHFFFAOYSA-N
- CAS DataBase Reference
- 288-94-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-Tetrazole(288-94-8)
- EPA Substance Registry System
- 1H-Tetrazole (288-94-8)
Safety
- Hazard Codes
- F,Xn,E
- Risk Statements
- 11-20/21/22-36-5-4
- Safety Statements
- 16-26-36-36/37-35-15
- RIDADR
- UN 1993 3/PG 2
- WGK Germany
- 3
- F
- 3-4.15-10
- HazardClass
- 4.1
- PackingGroup
- III
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H303May be harmfulif swallowed
H312Harmful in contact with skin
H319Causes serious eye irritation
H332Harmful if inhaled
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 88185
- Product name
- Tetrazole solution
- Purity
- for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile
- Packaging
- 100ml
- Price
- $178
- Updated
- 2024/03/01
- Product number
- 88185
- Product name
- Tetrazole solution
- Purity
- for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile
- Packaging
- 500ml
- Price
- $803
- Updated
- 2024/03/01
- Product number
- J61034
- Product name
- 1H-Tetrazole, 0.45M in acetonitrile
- Packaging
- 200ml
- Price
- $299
- Updated
- 2024/03/01
- Product number
- J61034
- Product name
- 1H-Tetrazole, 0.45M in acetonitrile
- Packaging
- 450ml
- Price
- $599
- Updated
- 2024/03/01
- Product number
- T307505
- Product name
- 1H-Tetrazole, 0.45M in acetonitrile
- Packaging
- 25ml
- Price
- $85
- Updated
- 2021/12/16
Tetrazole Chemical Properties,Usage,Production
Description
Tetrazole is a class of synthetic organic heterocyclic compound containing a 5-member ring of four nitrogen atoms and one carbon atom. It appears as an odorless white to light-yellow crystalline powder. It has several pharmaceutical applications. Tetrazole compound can act as a bioisotere for the carboxylate group, angiotensin II receptor blockers such as losartan and candesartan as well as dimethyl thiazolyl diphenyl tetrazolium bromide (MTT), which can be used in MTT assay for quantifying the respiratory activity of liver cells. It can also be used in DNA assays. In addition, Tetrazole derivatives have also been used in explosives such as TNT or high performance solid rocket propellant formulations. Tetrazole can be synthesized through the reaction between anhydrous hydrazoic acid and hydrogen cyanide under pressure.
References
https://en.wikipedia.org/wiki/Tetrazole
https://pubchem.ncbi.nlm.nih.gov/compound/1H-Tetrazole#section=Information-Sources
Chemical Properties
white crystals or crystalline powder
Uses
Tetrazole is a catalyst for phosphoramidite synthesis. It is also used as an intermediate for the drug cilostazol. Cilostazol is an antiplatelet drug and a vasodilator. Tetrazole derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.
Application
1H-Tetrazole is used as a bioisostere for the carboxylate group. It is also used as coupling reagent for preparation of polynucleotides.
Preparation
The first tetrazole synthesis was reported in 1885.
Tetrazole Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. This was then washed with cold chloroform. This simple procedure yielded pure tetrazole with good yields.
Definition
ChEBI: 1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one-carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole.
General Description
Tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition Tetrazole emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
Health Hazard
Fire may produce irritating, corrosive and/or toxic gases.
Fire Hazard
MAY EXPLODE AND THROW FRAGMENTS 1600 meters (1 MILE) OR MORE IF FIRE REACHES CARGO.
Purification Methods
Crystallise the tetrazole from EtOH and sublime it under high vacuum at ca 120o (care should be taken due to possible EXPLOSION). [Beilstein 26 H 346, 26 I 108, 26 II 196, 26 III/IV 1652.]
Tetrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tetrazole manufacturers
- Product
- Tetrazole 288-94-8
- Price
- US $13.00-7.00/kg
- Min. Order
- 500kg
- Purity
- 99.9
- Supply Ability
- 200tons
- Release date
- 2024-03-13
- Product
- Tetrazole 288-94-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 300MT/month
- Release date
- 2022-11-23
- Product
- Tetrazole 288-94-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-09-20