N-Phenyl-isobutyloylacetamide
- Product Name
- N-Phenyl-isobutyloylacetamide
- CAS No.
- 124401-38-3
- Chemical Name
- N-Phenyl-isobutyloylacetamide
- Synonyms
- Isobutyrylacetanilide;2-Isobutyrylacetanilide;Atorvastatin Impurity 66;Atorvastatin Impurity 197;N-PHENYL ISOBUTYRYLACETAMIDE;N-PHENYL-ISOBUTYLOYLACETAMIDE;N-PhNeyl-isobutyloyl Acetamide;Atorvastatin calcium impurity 65;N-Phenyl-4-Methyl-3-oxopentanaMide;4-methyl-3-oxo-n-phenyl-pentanamide
- CBNumber
- CB4233839
- Molecular Formula
- C12H15NO2
- Formula Weight
- 205.25
- MOL File
- 124401-38-3.mol
N-Phenyl-isobutyloylacetamide Property
- Melting point:
- 47 - 49°C
- Boiling point:
- 261-264 °C
- Density
- 1.103
- Flash point:
- 159°C
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Metahnol (Slightly)
- pka
- 12.14±0.46(Predicted)
- form
- Solid
- color
- Off-White to Pale Pink
- InChI
- InChI=1S/C12H15NO2/c1-9(2)11(14)8-12(15)13-10-6-4-3-5-7-10/h3-7,9H,8H2,1-2H3,(H,13,15)
- InChIKey
- ADHRFDCBLJVNFO-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=CC=C1)(=O)CC(=O)C(C)C
- CAS DataBase Reference
- 124401-38-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- P335325
- Product name
- N-PhenylIsobutyrylacetamide
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- P335325
- Product name
- N-PhenylIsobutyrylacetamide
- Packaging
- 2g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 286793
- Product name
- N-Phenyl isobutyrylacetamide
- Packaging
- 100mg
- Price
- $406
- Updated
- 2021/12/16
- Product number
- J94071
- Product name
- 4-Methyl-3-oxo-N-phenyl-pentanamide
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- CHM0014770
- Product name
- N-PHENYL ISOBUTYRYLACETAMIDE
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1166.55
- Updated
- 2021/12/16
N-Phenyl-isobutyloylacetamide Chemical Properties,Usage,Production
Chemical Properties
Yellow Oil
Uses
N-Phenyl Isobutyrylacetamide (cas# 124401-38-3) is a compound useful in organic synthesis.
Synthesis
42558-54-3
62-53-3
124401-38-3
To a 1000 mL dry three-necked flask were sequentially added 60 g (0.416 mol) of methyl isobutyrylacetate, 120 g (1.288 mol) of aniline and 6 g of 4-dimethylaminopyridine (DMAP). Stirring was turned on and the temperature was slowly increased to an internal temperature of 100 °C and the reaction was maintained at this temperature for 16 hours. During the reaction, the methanol generated was collected by a fractionation device. At the end of the reaction, the system was cooled down to 70 °C and the unreacted aniline was recovered by distillation under reduced pressure, and a total of 74.7 g of aniline was recovered with 92% recovery. After the remaining reaction solution was concentrated to about 100 g, 1 kg of water was added, cooled to 30 °C and stirred to crystallize for more than 5 hours. The product was filtered, the cake was washed with water for 3 times, and dried to give a white solid product of 82.3 g. The product was analyzed by HPLC with a purity of 99.8% and a yield of 96.4%.
References
[1] Patent: CN106397241, 2017, A. Location in patent: Paragraph 0014; 0015; 0016; 0017; 0018; 0019; 0020; 0021
[2] Patent: WO2012/143933, 2012, A1. Location in patent: Page/Page column 21-22
[3] Organic and Biomolecular Chemistry, 2016, vol. 14, # 7, p. 2291 - 2296
[4] Synthetic Communications, 2015, vol. 45, # 24, p. 2832 - 2840
[5] Journal of Heterocyclic Chemistry, 2007, vol. 44, # 4, p. 923 - 926
N-Phenyl-isobutyloylacetamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-Phenyl-isobutyloylacetamide Suppliers
- Tel
- 13853550371
- yang11360@163.com
- Country
- China
- ProdList
- 28
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 793-33899567 13735087952
- Fax
- +86-570-6259526
- sales@afmpharm.com
- Country
- China
- ProdList
- 76
- Advantage
- 61
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16077
- Advantage
- 64
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11705
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 3997
- Advantage
- 55
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7783
- Advantage
- 58
- Tel
- 13971561712, 13995564702, 027-50664929
- Fax
- 027-50664927
- hbeixys2001@163.com
- Country
- China
- ProdList
- 3120
- Advantage
- 55
- Tel
- 0554-2106669
- Fax
- 0554-2666215
- sales1@kedichem.com
- Country
- China
- ProdList
- 4924
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 400-8592883
- Fax
- 0731-82251112
- sales@huatengsci.com
- Country
- China
- ProdList
- 5872
- Advantage
- 58
- Tel
- 027-59262863 13277907145 3091977954
- Fax
- 027-59420980
- Country
- China
- ProdList
- 4942
- Advantage
- 58
- Tel
- +86-021-58380978 13482386415
- Fax
- 021-58380978
- info@systeambc.com
- Country
- China
- ProdList
- 896
- Advantage
- 50
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- +86 (21) 61124340
- Fax
- +86 (21) 6129-4103
- Country
- China
- ProdList
- 9756
- Advantage
- 58
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9858
- Advantage
- 58
- Tel
- Fax
- -
- xg01_gj@163.com
- Country
- China
- ProdList
- 9484
- Advantage
- 50
- Tel
- 0570-8789886 18892685668
- Fax
- 0570-8789985
- info@rundongchemical.com
- Country
- China
- ProdList
- 4053
- Advantage
- 60
- Tel
- 0371-53765687 18937137882
- Fax
- QQ:2885373884
- 2853979813@qq.com
- Country
- China
- ProdList
- 7991
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 025-83453382-8005
- Fax
- 025-83453382
- sale@parabiochem.com
- Country
- China
- ProdList
- 9595
- Advantage
- 55
- Tel
- 4009903999 13395398332
- Fax
- 0539-6365991
- sales@xiyashiji.com
- Country
- China
- ProdList
- 20794
- Advantage
- 60
- Tel
- 13391486464
- Fax
- QQ:14748090
- samwjf@163.com
- Country
- China
- ProdList
- 3086
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0751-2886750 13927877953
- Fax
- 0751-2886750
- 3005811397@qq.com
- Country
- China
- ProdList
- 13305
- Advantage
- 58
- Tel
- 025-52343882 18112933882
- Fax
- 025-52343882
- sales@kldbio.com
- Country
- China
- ProdList
- 2019
- Advantage
- 55
- Tel
- 13127280945
- 285424065@qq.com
- Country
- China
- ProdList
- 9976
- Advantage
- 55
- Tel
- 0539-6362799 20）
- Fax
- 0539-6362799（To 20）
- Country
- China
- ProdList
- 9998
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 021-37581181
- Fax
- 021-57456066
- sales@chem-mall.com
- Country
- China
- ProdList
- 10330
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 400-6387771-6039 18920764717
- sales@heowns.com
- Country
- China
- ProdList
- 23771
- Advantage
- 60
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 027-51831887 15337167856
- Fax
- 027-51837635 QQ1165326703
- hubeixinyuanshun@163.com
- Country
- China
- ProdList
- 10295
- Advantage
- 58
- Tel
- 0371-037163312495,13303845143 13303845143
- Fax
- QQ3001379618
- 3001379618@qq.com
- Country
- China
- ProdList
- 10267
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 12878
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
View Lastest Price from N-Phenyl-isobutyloylacetamide manufacturers
- Product
- 4-methyl-3-oxo-N-phenyl pentanamide 124401-38-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500
- Release date
- 2023-06-27
- Product
- N-Phenyl-isobutyloylacetamide 124401-38-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-12-22