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Pilocarpine nitrate

Product Name
Pilocarpine nitrate
CAS No.
148-72-1
Chemical Name
Pilocarpine nitrate
Synonyms
Nitrat;Pilocarpine nitrate for system suitability CRS;Pilagan;pilofrin;Pilocarpinnitrat;Einecs 205-723-7;Pilocarpin Nitrate;Pilocarpini nitras;PILOCARPINE NITRATE;p.v.carpineliquifilm
CBNumber
CB4237796
Molecular Formula
C11H17N3O5
Formula Weight
271.27
MOL File
148-72-1.mol
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Pilocarpine nitrate Property

Melting point:
173,5-174°C
alpha 
D +77 to +83° (c = 10)
refractive index 
81 ° (C=2, H2O)
storage temp. 
2-8°C
solubility 
H2O: 0.1 g/mL, clear, very faintly yellow
form 
powder
color 
white
optical activity
[α]25/D +83°, c = 10 in H2O(lit.)
Merck 
14,7424
BRN 
4171406
CAS DataBase Reference
148-72-1(CAS DataBase Reference)
EPA Substance Registry System
Pilocarpine nitrate (148-72-1)
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Safety

Hazard Codes 
Xn,T+
Risk Statements 
22-26/28
Safety Statements 
1-25-45
RIDADR 
3087
WGK Germany 
3
RTECS 
TK1455000
F 
3-10
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2939800000
Toxicity
LD50 oral in rat: 911mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H272May intensify fire; oxidizer

H302Harmful if swallowed

H330Fatal if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P220Keep/Store away from clothing/…/combustible materials.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0597
Product name
Pilocarpine nitrate
Purity
meets USP testing specifications
Packaging
5g
Price
$439
Updated
2024/03/01
Sigma-Aldrich
Product number
P0597
Product name
Pilocarpine nitrate
Purity
meets USP testing specifications
Packaging
25g
Price
$918
Updated
2024/03/01
Sigma-Aldrich
Product number
BP503
Product name
Pilocarpine nitrate
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
200MG
Price
$223
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000106
Product name
Pilocarpine nitrate for system suitability
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000106
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR1494
Product name
Pilocarpine nitrate
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$124
Updated
2024/03/01
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Pilocarpine nitrate Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder or colourless crystals, sensitive to light.

Uses

antiglaucoma agent, miotic

Uses

Antiglaucoma drug;Cholinergic

Uses

Pilocarpine nitrate salt has been used to measure bronchoconstriction and M2 and M3 muscarinic receptor function in vivo. It has also been used to induce electrographic and behavioral seizures and to study the different patterns of neuronal activation and neurodegeneration in Proechimys rats and Wistar rats.

brand name

Pilagan (Allergan).

General Description

Pilocarpine mononitrate occursas shining white crystals that are not hygroscopic butare light sensitive. It is soluble in water (1:4) and alcohol(1:75) but insoluble in chloroform and ether. Aqueoussolutions are slightly acid to litmus and may be sterilizedin the autoclave. The alkaloid is incompatible with alkalies,iodides, silver nitrate, and reagents that precipitatealkaloids.

Biochem/physiol Actions

Pilocarpine is a cholinergic muscarinic agonist, useful in inducing epilepsy in animal models. It is specially used to study the pathogenesis of epileptogenesis and pharmacoresistant epilepsy. Pilocarpine application is more popular among the rat and mice models.

Pilocarpine nitrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pilocarpine nitrate Suppliers

Americas 1 Brazil 3 Canada 1 China 70 Czech Republic 1 Europe 2 France 2 Germany 6 India 9 Ireland 1 Japan 1 Mexico 1 Switzerland 2 The Netherlands 1 United Kingdom 5 United States 28 Global 134
LGM Pharma
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View Lastest Price from Pilocarpine nitrate manufacturers

Henan Fengda Chemical Co., Ltd
Product
Pilocarpine nitrate 148-72-1
Price
US $35.00-1.30/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Dideu Industries Group Limited
Product
Pilocarpine nitrate 148-72-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-27

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