2,4'-Dibromoacetophenone

ChemicalBook > CAS DataBase List > 2,4'-Dibromoacetophenone

2,4'-Dibromoacetophenone

Product Name: 2,4'-Dibromoacetophenone
CAS No.: 99-73-0
Chemical Name: 2,4'-Dibromoacetophenone
Synonyms: 99-73-0;2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE;PBPB;2-BROMO-1-(4-BROMOPHENYL)ETHANONE;P-BROMOPHENACYL BROMIDE;4-BROMOPHENACYL BROMIDE;p-bromophenacyl-8;AKOS BBS-00000865;GSK-3β Inhibitor VII;BromophenacylBromide
CBNumber: CB4239093
Molecular Formula: C8H6Br2O
Formula Weight: 277.94
MOL File: 99-73-0.mol

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2,4'-Dibromoacetophenone Property

Melting point:: 108-110 °C(lit.)
Boiling point:: 1415°C/760mm
Density: 1.7855 (rough estimate)
refractive index: 1.5560 (estimate)
storage temp.: Store below +30°C.
solubility: DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol
form: Crystalline Solid
color: Slightly yellow to beige
Water Solubility: Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water.
Sensitive: Lachrymatory
Merck: 14,1427
BRN: 607604
Stability:: Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.
InChIKey: FKJSFKCZZIXQIP-UHFFFAOYSA-N
CAS DataBase Reference: 99-73-0(CAS DataBase Reference)
EPA Substance Registry System: Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 2
RTECS: AM6950000
F: 19-21
Hazard Note: Corrosive/Lachrymatory
TSCA: T
HazardClass: 8
PackingGroup: III
HS Code: 29147090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 68082
Product name: 2,4′-Dibromoacetophenone
Purity: for HPLC derivatization, ≥99.0% (HPLC)
Packaging: 5g
Price: $78.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 361548
Product name: GSK-3β Inhibitor VII
Packaging: 5mg
Price: $172
Updated: 2024/03/01

TCI Chemical

Product number: A5501
Product name: 4-Bromophenacyl Bromide [for HPLC Labeling]
Purity: >99.0%(T)
Packaging: 5g
Price: $115
Updated: 2024/03/01

TCI Chemical

Product number: D0164
Product name: 4-Bromophenacyl Bromide
Purity: >98.0%(GC)
Packaging: 25g
Price: $35
Updated: 2024/03/01

Alfa Aesar

Product number: A13687
Product name: 2,4'-Dibromoacetophenone, 98+%
Packaging: 25g
Price: $62.65
Updated: 2024/03/01

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2,4'-Dibromoacetophenone Chemical Properties,Usage,Production

Chemical Properties

2,4'-Dibromoacetophenone is off-white crystals or powder

Uses

Identification of carboxylic acids.

Uses

Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3

Uses

2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids.

General Description

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM.

Biochem/physiol Actions

Cell permeable: yes

Purification Methods

Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.]

2,4'-Dibromoacetophenone Preparation Products And Raw materials

Raw materials

4'-Bromoacetophenone

Preparation Products

2-(4-BROMOBENZOYL)-1-BENZOFURAN-5-CARBALDEHYDE 3-(4-BROMOPHENYL)ISOXAZOL-5-AMINE

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View Lastest Price from 2,4'-Dibromoacetophenone manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: 2,4'-Dibromoacetophenone 99-73-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-31

Hebei Mojin Biotechnology Co., Ltd

Product: 2,4'-Dibromoacetophenone 99-73-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-31

Anhui Ruihan Technology Co., Ltd

Product: 2,4'-Dibromoacetophenone 99-73-0
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000tons
Release date: 2023-08-23

99-73-0, 2,4'-DibromoacetophenoneRelated Search:

3-Nitroacetophenone 4-Bromophenethyl alcohol Bromoacetyl bromide 4-Nitroacetophenone 4-Bromoanisole L-PICEIN Ethidium bromide Clidinium bromide 4'-Methoxyacetophenone Sodium bromate Acetophenone 4-Bromobenzotrifluoride 4-Bromotoluene 4-Bromobenzaldehyde 2',4'-Difluoroacetophenone 1,4-Dibromobenzene Acetyl bromide 3-Aminoacetophenone

P-BROMOPHENACYL BROMIDE

PBPB

OMEGA-BROMOACETOPHENONE

bromomethyl4-bromophenylketone

bromomethylp-bromophenylketone

omega,4-dibromoacetophenone

p,alpha-dibromoacetophenone

p-bromophenacyl-8

p-Dibromoacetophenone

2,4’-dibromo-acetophenon

2-bromo-1-(4-bromophenyl)-ethanon

4,alpha-dibromoacetophenone

4-bromo(bromoacetyl)benzene

-4-Dibromoacetophenone

4-BROMOPHENACYL BROMIDE [FOR HPLC LABELING]

4-BROMOPHENACYL BROMIDE (2,4''-DIBROMOACETOPHENONE)

2,4'-Dibromoacetophenone, 98+%

PARA-BROMOPHENACYLBROMIDE

Acetophenone, 2,4'-dibromo

2,4'-Dibromoacetophenone

GSK-3β Inhibitor VII

2,4′-Dibromoacetophenone,4′-Bromophenacyl bromide

2-Bromo-4'-bromoacetophenone

4-Bromophenacyl Bromide 99% Ar

GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem

a,4-Dibromoacetophenone

4-BROMOPHENACYL BROMIDE, FOR FLUOR-ESCEN CE

BromophenacylBromide

4-BromophenacylBromide98%

4-Bromophenacyl Bromide 98%

Ethanone, 2-bromo-1-(4-bromophenyl)-

à-4-dibromoacetophenone

ω.ρ-Dibromoacetoplenone

2,4'-DibroMo-acetophenone &gt

2,4- twobroMoacetophenone

2,4'-DibroMoacetophenone, 97+%

99-73-0

2,4'-Dibromoacetophenone puriss., >=98.5% (HPLC)

ALPHA,4'-DIBROMOACETOPHENONE

ALPHA-4-DIBROMOACETOPHENONE

ALPHA,P-DIBROMOACETOPHENONE

AKOS BBS-00000865

4'-BROMOPHENACYL BROMIDE

4-BROMOPHENACYL BROMIDE

4,OMEGA-DIBROMOACETOPHENONE

2-BROMO-1-(4-BROMOPHENYL)ETHANONE

2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE

A,P-DIBROMOACETOPHENONE

GSK-3BETA INHIBITOR VII

DIBROMOACETOPHENONE-2,4

Platinum oxide monohydrate (IV)

4-Bromophenacyl Bromide &gt

4-Bromophenacyl Bromide [for HPLC Labeling]&gt

2,4'-DIBROMOACETOPHENONE FOR SYNTHESIS

2,4′-dibromoacetophenone 2

2,4'-Dibromoacetophenone

99-73-0

BrCH2COC6H4Br