ChemicalBook > CAS DataBase List > N-Benzyloxycarbonyl-D-aspartic acid

N-Benzyloxycarbonyl-D-aspartic acid

Product Name
N-Benzyloxycarbonyl-D-aspartic acid
CAS No.
78663-07-7
Chemical Name
N-Benzyloxycarbonyl-D-aspartic acid
Synonyms
Z-D-ASP-OH;Z-D-ASP;CBZ-D-ASP-OH;N-CBZ-D-ASP-OH;Cbz-D-Aspartic;Z-D-ASPARTIC ACID;CBZ-D-ASPARTIC ACID;Z-D-Asp-OH, >=98.0%;Z-D-Asp-OH;Z-D-aspartic acid99%
CBNumber
CB4242062
Molecular Formula
C12H13NO6
Formula Weight
267.23
MOL File
78663-07-7.mol
More
Less

N-Benzyloxycarbonyl-D-aspartic acid Property

Melting point:
117 °C
Boiling point:
472.8±45.0 °C(Predicted)
Density 
1.404±0.06 g/cm3(Predicted)
refractive index 
-10 ° (C=7, AcOH)
storage temp. 
Sealed in dry,2-8°C
solubility 
Methanol (Sparingly)
pka
3.75±0.23(Predicted)
form 
Solid
color 
White to Off-White
optical activity
Consistent with structure
BRN 
2566464
CAS DataBase Reference
78663-07-7(CAS DataBase Reference)
More
Less

Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29242990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
95965
Product name
Z-D-Asp-OH
Purity
≥98.0%
Packaging
5g
Price
$49.3
Updated
2022/05/15
TCI Chemical
Product number
C0689
Product name
N-Carbobenzoxy-D-aspartic Acid
Purity
>98.0%(T)
Packaging
1g
Price
$16
Updated
2025/07/31
TCI Chemical
Product number
C0689
Product name
N-Carbobenzoxy-D-aspartic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$34
Updated
2025/07/31
TRC
Product number
C176280
Product name
N-Carbobenzyloxy-D-asparticAcid
Packaging
5g
Price
$65
Updated
2021/12/16
Usbiological
Product number
242660
Product name
Z-D-aspartic acid 99+%
Packaging
5g
Price
$156
Updated
2021/12/16
More
Less

N-Benzyloxycarbonyl-D-aspartic acid Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A competitive inhibitor of indole-3-acetyl-L-aspartic acid hydrolase of Enterobacter agglomerans.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

1783-96-6

501-53-1

78663-07-7

The general procedure for the synthesis of Cbz-D-aspartic acid from D-aspartic acid and benzyl chloroformate is as follows: 1. 6 M NaOH solution was added to 500 mL of distilled water at 0 °C and the pH of the solution was adjusted to 13. Subsequently, 65 g (489 mmol) of (R)-aspartic acid was added. 2. 141 g (831 mmol, 1.7 eq.) of benzyl chloroformate was slowly added to the above solution under magnetic stirring. 3. The reaction mixture was stirred at room temperature for 2 days. 4. 4. After completion of the reaction, the mixture was washed with ether and the aqueous phase was acidified with 6 N HCl to pH < 2. 5. 5. The acidified aqueous phase was extracted with ethyl acetate (AcOEt) and the organic phases were combined. 6. The organic phase was dried with anhydrous Na2SO4, filtered, and concentrated in a rotary evaporator to give 80 g of a clear, colorless gelatinous product in 59% yield. Product Characterization: - MS (ESI) m/e (MH+): 266 - 1H-NMR (CDCl3, 400 MHz): δ 7.21-7.21 (m, 5H), 6.14 (d, J = 8.4 Hz, 1H), 5.05 (s, 2H), 4.60 (m, 1H), 2.99 (m, 1H), 2.75 (m, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1040 - 1044
[2] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 17, p. 2495 - 2511
[3] Asian Journal of Chemistry, 2013, vol. 25, # 11, p. 5948 - 5950
[4] Patent: WO2008/61208, 2008, A2. Location in patent: Page/Page column 31-32; 34-35
[5] Patent: US6660769, 2003, B1. Location in patent: Page column 13-14

N-Benzyloxycarbonyl-D-aspartic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-Benzyloxycarbonyl-D-aspartic acid Suppliers

Americas 1 Canada 1 China 198 Europe 3 Germany 5 India 19 Japan 4 Switzerland 4 United Kingdom 6 United States 36 Global 277
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16077
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9546
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Tianjin Chempharmatech Co.,Ltd.
Tel
022-66211079 13212288319
Fax
qq1405432731
Email
sales@chempharmatech.com
Country
China
ProdList
918
Advantage
55
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Amatek Scientific Co. Ltd.
Tel
0512-56316828 4008675858
Fax
+86-512-56316826
Email
sales@amateksci.com
Country
China
ProdList
9874
Advantage
55
Ningbo Taikang Chemical Co., Ltd.
Tel
0574-87365517 18074210286
Fax
87367735
Email
sales@taikangchem.com
Country
China
ProdList
294
Advantage
58
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7778
Advantage
56
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Chengdu Chuangkecheng Biological Technology Co., Ltd.
Tel
028-028-0000000 13008177686
Fax
15928581901
Email
sales@ckcbiotech.com
Country
China
ProdList
904
Advantage
55
Quzhou Rundong Chemical (Technology) Co.
Tel
0570-8789886 18892685668
Fax
0570-8789985
Email
info@rundongchemical.com
Country
China
ProdList
4053
Advantage
60
Changzhou Anxuan Chemical, Co., Ltd.
Tel
13912302692 13912302692;
Fax
0519-88064678
Email
sales@anxuanchem.com
Country
China
ProdList
4828
Advantage
58
Beijing NuoqiYa Biotechnology Co., Ltd.
Tel
4000-819-385 010-62329685 13718666987
Fax
010-62340519
Country
China
ProdList
1971
Advantage
55
Chengdu Research Accelerators Technology Co., Ltd.
Tel
028-64353063
Fax
028-64353063 QQ:784253935
Email
reacchemical@163.com
Country
China
ProdList
5253
Advantage
58
Chengdu RunZeBenTu Chemical Co., Ltd
Tel
028-88469284 18000562381
Email
rzbtsj@163.com
Country
China
ProdList
9951
Advantage
56
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
Advantage
55
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
ShangHai Siyan Biological Technology Co., Ltd.
Tel
021-50908862，442785678，326799392 18721037013
Fax
021-50908862
Email
siyansales@126.com
Country
China
ProdList
9627
Advantage
58
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9287
Advantage
55
Nanjing XiLang Chemical Products Co., Ltd.
Tel
18936048580
Email
chemxilang@163.com
Country
China
ProdList
3909
Advantage
58
Shanghai Xilong Biochemical Technology Co., Ltd.
Tel
021-52907766-8042
Fax
021-52906523
Country
China
ProdList
9941
Advantage
58
More
Less

View Lastest Price from N-Benzyloxycarbonyl-D-aspartic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
N-Benzyloxycarbonyl-D-aspartic acid 78663-07-7
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Career Henan Chemical Co
Product
N-Benzyloxycarbonyl-D-aspartic acid 78663-07-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-22

78663-07-7, N-Benzyloxycarbonyl-D-aspartic acidRelated Search:

Poly-L-aspartic acid Glycine D-Aspartic acid Folic acid Ethyl 2-(Chlorosulfonyl)acetate L-ASPARTIC ACID Z-D-ASP(OTBU)-OH H2O Citric acid Z-D-Glu-OMe Z-D-ASP(OBZL)-OH Z-D-Asp(OtBu)-OH, H2O Z-D-Asp-OMe D-Aspartic acid, N-[(phenylmethoxy)carbonyl]-, 1-(phenylmethyl) ester Cbz-Gly-Gly CBZ-L-ALANINOL Z-GLY-NH2 N-Benzyloxycarbonyl-6-aminohexanoic acid N-Cbz-L-Serine

  • 2-phenylmethoxycarbonylaminobutanedioic acid
  • BENZYLOXYCARBONYL-D-ASPARTIC ACID
  • N-CARBOBENZOXY-D-ASPARTIC ACID
  • N-Benzyloxycarbonyl-D-aspartic acid
  • N-ALPHA-CBZ-D-ASPARTIC ACID
  • CBZ-D-ASPARTIC ACID
  • CBZ-D-ASP-OH
  • N-CBZ-D-ASPARTIC ACID
  • Z-D-aspartic acid99%
  • (2R)-2-{[(benzyloxy)carbonyl]amino}butanedioic acid
  • (2R)-2-(phenylmethoxycarbonylamino)butanedioic acid
  • <i>N</i>-Carbobenzoxy-<small>D</small>-aspartic Acid
  • N-ALPHA-BENZYLOXYCARBONYL-D-ASPARTIC ACID
  • N-ALPHA-CARBOBENZOXY-D-ASPARTIC ACID
  • Z-D-ASPARTIC ACID
  • Z-D-ASP-OH
  • N-Cbz-D-asparticacid,96%
  • N-CBZ-D-ASP-OH
  • Z-D-ASP
  • (S)-2-(BENZYLOXYCARBONYLAMINO)SUCCINIC ACID CBZ-D-ASP-OH
  • N-[(PHENYLMETHOXY)CARBONYL]-D-ASPARTIC ACID
  • N-Carbobenzyloxy-D-aspartic acid
  • (R)-2-(benzyloxycarbonylamino)succinic acid
  • (R)-2-[[(Benzyloxy)carbonyl]amino]butanedioate
  • N-Cbz-D-aspartic Acid Z-D-Asp-OH
  • D-Aspartic acid, N-[(phenylMethoxy)carbonyl]-
  • Cbz-D-Aspartic
  • Z-D-Asp-OH, >=98.0%
  • N-Carbobenzoxy-D-aspartic Acid &gt
  • iNi-Carbobenzoxy-smallDsmall-asparticAci
  • N-Benzyloxycarbonyl-D-aspartic acid USP/EP/BP
  • Z-D-Aspartic Acid extrapure, 99%
  • N-Cbz-D-aspartic acid, 98% [Z-D-AspOH]
  • Z-<sc>D</sc>-Asp-OH
  • 78663-07-7
  • 78663-07-0
  • Peptide Synthesis
  • Specialty Synthesis
  • Protected & Labeled Amino Acids
  • Cbz-Amino Acids
  • Amino Acids (N-Protected)
  • Aspartic Acid
  • Amino Acid Derivatives
  • Amino Acids & Derivatives
  • Aromatics
  • Inhibitors
  • Aspartic acid [Asp, D]
  • Z-Amino Acids and Derivatives
  • Amino Acids
  • Amino Acids (N-Protected)
  • Biochemistry
  • Cbz-Amino Acids
  • Z-Amino acid series