N-Benzyloxycarbonyl-D-aspartic acid

Product Name: N-Benzyloxycarbonyl-D-aspartic acid
CAS No.: 78663-07-7
Chemical Name: N-Benzyloxycarbonyl-D-aspartic acid
Synonyms: Z-D-ASP-OH;Z-D-ASP;CBZ-D-ASP-OH;N-CBZ-D-ASP-OH;Cbz-D-Aspartic;Z-D-ASPARTIC ACID;CBZ-D-ASPARTIC ACID;Z-D-Asp-OH, >=98.0%;Z-D-Asp-OH;Z-D-aspartic acid99%
CBNumber: CB4242062
Molecular Formula: C12H13NO6
Formula Weight: 267.23
MOL File: 78663-07-7.mol

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N-Benzyloxycarbonyl-D-aspartic acid Property

Melting point:: 117 °C
Boiling point:: 472.8±45.0 °C(Predicted)
Density: 1.404±0.06 g/cm3(Predicted)
refractive index: -10 ° (C=7, AcOH)
storage temp.: Sealed in dry,2-8°C
solubility: Methanol (Sparingly)
pka: 3.75±0.23(Predicted)
form: Solid
color: White to Off-White
optical activity: Consistent with structure
BRN: 2566464
CAS DataBase Reference: 78663-07-7(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 95965
Product name: Z-D-Asp-OH
Purity: ≥98.0%
Packaging: 5g
Price: $49.3
Updated: 2022/05/15

TCI Chemical

Product number: C0689
Product name: N-Carbobenzoxy-D-aspartic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: C0689
Product name: N-Carbobenzoxy-D-aspartic Acid
Purity: >98.0%(T)
Packaging: 5g
Price: $34
Updated: 2025/07/31

TRC

Product number: C176280
Product name: N-Carbobenzyloxy-D-asparticAcid
Packaging: 5g
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 242660
Product name: Z-D-aspartic acid 99+%
Packaging: 5g
Price: $156
Updated: 2021/12/16

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N-Benzyloxycarbonyl-D-aspartic acid Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A competitive inhibitor of indole-3-acetyl-L-aspartic acid hydrolase of Enterobacter agglomerans.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

1783-96-6

501-53-1

78663-07-7

The general procedure for the synthesis of Cbz-D-aspartic acid from D-aspartic acid and benzyl chloroformate is as follows: 1. 6 M NaOH solution was added to 500 mL of distilled water at 0 °C and the pH of the solution was adjusted to 13. Subsequently, 65 g (489 mmol) of (R)-aspartic acid was added. 2. 141 g (831 mmol, 1.7 eq.) of benzyl chloroformate was slowly added to the above solution under magnetic stirring. 3. The reaction mixture was stirred at room temperature for 2 days. 4. 4. After completion of the reaction, the mixture was washed with ether and the aqueous phase was acidified with 6 N HCl to pH < 2. 5. 5. The acidified aqueous phase was extracted with ethyl acetate (AcOEt) and the organic phases were combined. 6. The organic phase was dried with anhydrous Na2SO4, filtered, and concentrated in a rotary evaporator to give 80 g of a clear, colorless gelatinous product in 59% yield. Product Characterization: - MS (ESI) m/e (MH+): 266 - 1H-NMR (CDCl3, 400 MHz): δ 7.21-7.21 (m, 5H), 6.14 (d, J = 8.4 Hz, 1H), 5.05 (s, 2H), 4.60 (m, 1H), 2.99 (m, 1H), 2.75 (m, 1H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 3, p. 1040 - 1044
[2] Journal of the Chemical Society - Perkin Transactions 1, 1997, # 17, p. 2495 - 2511
[3] Asian Journal of Chemistry, 2013, vol. 25, # 11, p. 5948 - 5950
[4] Patent: WO2008/61208, 2008, A2. Location in patent: Page/Page column 31-32; 34-35
[5] Patent: US6660769, 2003, B1. Location in patent: Page column 13-14

N-Benzyloxycarbonyl-D-aspartic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Benzyloxycarbonyl-D-aspartic acid Suppliers

Americas 1 Canada 1 China 198 Europe 3 Germany 5 India 19 Japan 4 Switzerland 4 United Kingdom 6 United States 36 Global 277

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View Lastest Price from N-Benzyloxycarbonyl-D-aspartic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: N-Benzyloxycarbonyl-D-aspartic acid 78663-07-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Career Henan Chemical Co

Product: N-Benzyloxycarbonyl-D-aspartic acid 78663-07-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-22

78663-07-7, N-Benzyloxycarbonyl-D-aspartic acidRelated Search:

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N-[(PHENYLMETHOXY)CARBONYL]-D-ASPARTIC ACID

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N-Cbz-D-aspartic Acid Z-D-Asp-OH

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Z-<sc>D</sc>-Asp-OH

78663-07-7

78663-07-0

Peptide Synthesis

Specialty Synthesis

Protected & Labeled Amino Acids

Cbz-Amino Acids

Amino Acids (N-Protected)

Aspartic Acid

Amino Acid Derivatives

Amino Acids & Derivatives

Aromatics

Inhibitors

Aspartic acid [Asp, D]

Z-Amino Acids and Derivatives

Amino Acids

Amino Acids (N-Protected)

Biochemistry

Cbz-Amino Acids

Z-Amino acid series