8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester

Product Name: 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester
CAS No.: 25368-09-6
Chemical Name: 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester
Synonyms: β-Crocetin;Crocetin methylester;crocetin monomethyl ester;8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester;(2E,4E,6E,8E,10E,12E,14E)-16-Methoxy-2,6,11,15-tetramethyl-16-oxohexadeca-2,4,6,8,10,12,14-heptaenoic acid;2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, monomethyl ester, (2E,4E,6E,8E,10E,12E,14E)- (9CI)
CBNumber: CB42439455
Molecular Formula: C21H26O4
Formula Weight: 342.43
MOL File: 25368-09-6.mol

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8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester Property

storage temp.: Store at -20°C, sealed storage, away from moisture and light
solubility: Soluble in DMSO
form: Solid
color: Pink to red

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Hazard and Precautionary Statements (GHS)

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8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester Chemical Properties,Usage,Production

Uses

Crocetin monomethyl ester, isolated from Crocus sativus, possesses anti-inflammatory, neuroprotective and antioxidant activity[1][2]. Crocetin monomethyl ester promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway[4].

References

[1] Tseng TH, et al. Crocetin protects against oxidative damage in rat primary hepatocytes. Cancer Lett. 1995 Oct 20;97(1):61-7. DOI:10.1016/0304-3835(95)03964-x
[2] Ahmad AS, et al. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behav. 2005 Aug;81(4):805-13. DOI:10.1016/j.pbb.2005.06.007
[3] Nam KN, et al. Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. Eur J Pharmacol. 2010 Dec 1;648(1-3):110-6. DOI:10.1016/j.ejphar.2010.09.003
[4] Wani A, Al Rihani SB, Sharma A, et al. Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway. Autophagy. 2021;17(11):3813-3832. DOI:10.1080/15548627.2021.1872187

8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester Preparation Products And Raw materials

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25368-09-6, 8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl esterRelated Search:

Crocin trans-Crocetin (β-D-gentiobiosyl) ester Dimethylcrocetin 8,8'-DIAPOCAROTENEDIOIC ACID DisodiuM trans-crocetinate β-D-Glucopyranose, 1-[hydrogen (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 1,1'-[(2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate]-b-D-Glucopyranose Picrocrocin 1-[(2E,4E,6E,8E,10E,12E,14E)-b-D-glucopyranosyl 2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate] 6-O-b-D-glucopyranosyl-b-D-Glucopyranose

8,8'-Diapo-ψ,ψ-carotene-8,8'-dioic acid 8-methyl ester

crocetin monomethyl ester

2,4,6,8,10,12,14-Hexadecaheptaenedioic acid, 2,6,11,15-tetramethyl-, monomethyl ester, (2E,4E,6E,8E,10E,12E,14E)- (9CI)

β-Crocetin

Crocetin methylester

(2E,4E,6E,8E,10E,12E,14E)-16-Methoxy-2,6,11,15-tetramethyl-16-oxohexadeca-2,4,6,8,10,12,14-heptaenoic acid

25368-09-6