3,5-Difluorochlorobenzene
Application- Product Name
- 3,5-Difluorochlorobenzene
- CAS No.
- 1435-43-4
- Chemical Name
- 3,5-Difluorochlorobenzene
- Synonyms
- 3,5-Difluorchlorbenzol;5-Difluorochlorobenzene;3,5-DIFLUOROCHLOROBENZENE;1-CHLORO-3,5-DIFLUOROBENZENE;3,5-difluoro-dichlorobenzene;3,5-Difluorochlorobenzene 97%;1-Chloro-3,5-difluorobenzene97%;Benzene, 1-chloro-3,5-difluoro-;1-Chloro-3,5-difluorobenzene,95%;1-Chloro-3,5-difluorobenzene 97%
- CBNumber
- CB4244657
- Molecular Formula
- C6H3ClF2
- Formula Weight
- 148.54
- MOL File
- 1435-43-4.mol
3,5-Difluorochlorobenzene Property
- Boiling point:
- 111-112 °C (lit.)
- Density
- 1.329 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.465(lit.)
- Flash point:
- 85 °F
- storage temp.
- Sealed in dry,Room Temperature
- form
- clear liquid
- color
- Colorless to Almost colorless
- BRN
- 2205670
- InChI
- InChI=1S/C6H3ClF2/c7-4-1-5(8)3-6(9)2-4/h1-3H
- InChIKey
- RFKBODCWHNDUTJ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=CC(F)=CC(F)=C1
- CAS DataBase Reference
- 1435-43-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,F
- Risk Statements
- 10-36/37/38
- Safety Statements
- 37/39-26-16
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 2
- Hazard Note
- Flammable
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 537292
- Product name
- 1-Chloro-3,5-difluorobenzene
- Purity
- 95%
- Packaging
- 5g
- Price
- $61
- Updated
- 2023/06/20
- Product number
- C2514
- Product name
- 1-Chloro-3,5-difluorobenzene
- Purity
- >97.0%(GC)
- Packaging
- 5g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- C2514
- Product name
- 1-Chloro-3,5-difluorobenzene
- Purity
- >97.0%(GC)
- Packaging
- 25g
- Price
- $148
- Updated
- 2025/07/31
- Product number
- C377743
- Product name
- 1-Chloro-3,5-difluorobenzene
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J55000
- Product name
- 1-Chloro-3,5-difluorobenzene
- Packaging
- 4x25g
- Price
- $80
- Updated
- 2021/12/16
3,5-Difluorochlorobenzene Chemical Properties,Usage,Production
Application
3,5-Difluorochlorobenzene can be used as an intermediate in pesticide and pharmaceutical chemistry, and can be used in the synthesis of drug molecules, hormones, and bioactive molecules. In organic synthesis transformations, the chlorine atom in 3,5-difluorochlorobenzene can be converted into a boronic acid structure or a boronic ester derivative under the catalysis of the transition metal palladium.
Chemical Properties
clear colourless liquid
Synthesis
36556-56-6
1435-43-4
General procedure for the synthesis of 3,5-difluorochlorobenzene from 6-chloro-2,4-difluoroaniline: 1. 0.5 moles (1.0 equiv.) of 6-chloro-2,4-difluoroaniline and 200 ml of dichloromethane were added to a reaction flask and stirred until completely dissolved. 2. 0.55 moles (1.1 eq.) of N-chlorosuccinimide (NCS) was added in 5 batches, the reaction temperature was controlled at 10~15°C, and after the addition was completed, the reaction was heated to reflux for 2 hours. 3. The completion of the reaction was monitored by TLC and the pH was adjusted to 6-7 by adding 10% dilute hydrochloric acid to the reaction mixture. 4. The organic phase was separated, washed with water and rotary evaporated to dryness to give 0.44 mol (0.88 eq.) of 2,4-difluoro-5-chloroaniline. 5. 0.44 mol of 2,4-difluoro-5-chloroaniline was added to 1.5 mol (3 eq.) of 25% dilute sulfuric acid and stirred for 0.5 hr. 6. Add 0.75 mol (1.5 eq.) of sodium phosphite, control the reaction temperature at 30~35°C, slowly add 0.5 mol (1 eq.) of aqueous sodium nitrite dropwise, control the rate of dropwise acceleration so that the reaction temperature rises 4~5°C per hour. 7. Warm up to 60°C, keep the temperature stirring for 2 hours. 8. 8. leave to stratify, the organic phase is washed with water and then steam distilled. 9. 9. 0.41 moles (0.82 equivalents) of 3,5-difluorochlorobenzene were obtained by distillation, with a purity of 99.8%.
References
[1] Patent: CN106986741, 2017, A. Location in patent: Paragraph 0017; 0018; 0019; 0020; 0021; 0022
3,5-Difluorochlorobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Difluorochlorobenzene Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
- --
- Fax
- --
- nquiries@melrob.com
- Country
- United Kingdom
- ProdList
- 3065
- Advantage
- 58
- Tel
- --
- Fax
- --
- ales@apo
- Country
- United Kingdom
- ProdList
- 4521
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- United Kingdom
- ProdList
- 483
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
- Tel
- --
- Fax
- --
- sales@melford.co.uk
- Country
- United Kingdom
- ProdList
- 1516
- Advantage
- 64
- Tel
- --
- Fax
- --
- enquiry@leancare.co.uk
- Country
- United Kingdom
- ProdList
- 6446
- Advantage
- 42
- Tel
- --
- Fax
- --
- kevinbanks@molekula.com
- Country
- United Kingdom
- ProdList
- 6140
- Advantage
- 66
- Tel
- --
- Fax
- --
- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
- 30
- Tel
- --
- Fax
- --
- info@manchesterorganics.com
- Country
- United Kingdom
- ProdList
- 6834
- Advantage
- 67
- Tel
- --
- Fax
- --
- sales@etascientific.com
- Country
- United Kingdom
- ProdList
- 6090
- Advantage
- 34
- Tel
- --
- Fax
- --
- sales@gs-chem.com
- Country
- United Kingdom
- ProdList
- 6098
- Advantage
- 47
- Tel
- --
- Fax
- --
- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6375
- Advantage
- 65
- Tel
- --
- Fax
- --
- Country
- United Kingdom
- ProdList
- 6309
- Advantage
- 46
- Tel
- --
- Fax
- --
- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
- Tel
- --
- Fax
- --
- solutions@vwr.com
- Country
- United Kingdom
- ProdList
- 6548
- Advantage
- 82
- Tel
- --
- Fax
- --
- goldfinchlabs@hotmail.com
- Country
- United Kingdom
- ProdList
- 731
- Advantage
- 30
View Lastest Price from 3,5-Difluorochlorobenzene manufacturers
- Product
- 3,5-Difluorochlorobenzene 1435-43-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-06
- Product
- 3,5-Difluorochlorobenzene 1435-43-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-08
- Product
- 3,5-Difluorochlorobenzene 1435-43-4
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-26