ChemicalBook > CAS DataBase List > METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE

METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE

Uses

Product Name: METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE
CAS No.: 16420-39-6
Chemical Name: METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE
Synonyms: Vonoprazan Impurity 217;Methyl 5-Bromo-3-pyrrolecarboxylate;5-Bromo-3-(methoxycarbonyl)-1H-pyrrole;2-Bromo-4-(methoxycarbonyl)-1H-pyrrole;METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE;Methyl 5-bromo-1H-pyrrole-3-carboxylate 97+%;5-broMo-pyrrole-3-carboxylic acid Methyl ester;1H-Pyrrole-3-carboxylic acid, 5-bromo-, methyl ester
CBNumber: CB42451637
Molecular Formula: C6H6BrNO2
Formula Weight: 204.02
MOL File: 16420-39-6.mol

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METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE Property

storage temp.: Sealed in dry,Store in freezer, under -20°C
form: solid
color: Off-white

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: M295343
Product name: methyl5-bromo-1H-pyrrole-3-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M295343
Product name: methyl5-bromo-1H-pyrrole-3-carboxylate
Packaging: 50mg
Price: $110
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-9-X7
Product name: Methyl 5-bromo-1H-pyrrole-3-carboxylate
Packaging: 250mg
Price: $106
Updated: 2021/12/16

Matrix Scientific

Product number: 119492
Product name: Methyl 5-bromo-1H-pyrrole-3-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $179
Updated: 2021/12/16

AK Scientific

Product number: 8344AA
Product name: Methyl5-bromo-1H-pyrrole-3-carboxylate
Packaging: 1g
Price: $262
Updated: 2021/12/16

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METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE Chemical Properties,Usage,Production

Uses

methyl 5-bromo-1H-pyrrole-3-carboxylate is a useful research chemical.

Synthesis

2703-17-5

16420-39-6

General procedure for the synthesis of methyl 5-bromo-3-pyrrolecarboxylate from methyl 3-pyrrolecarboxylate: Referring to the literature method (Example 22, Synthesis of methyl 5-bromo-1H-pyrrole-3-carboxylate); dissolve methyl 1H-pyrrole-3-carboxylate (3.06 g) in tetrahydrofuran (30 mL) and cool to -78°C. Under stirring, N-bromosuccinimide (4.38 g) and pyridine (3 drops) were added sequentially. The reaction mixture was kept stirred at -78 °C for 1 hour. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic layers were combined and washed sequentially with saturated aqueous sodium bicarbonate, water and saturated saline. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=5:1) to afford methyl 5-bromo-3-pyrrolecarboxylate (3.08 g, 62% yield) as a pale yellow solid. The structure of the product was confirmed by 1H-NMR (CDCl3): δ 3.81 (3H, s), 6.58 (1H, m), 7.36 (1H, m), 8.60 (1H, brs).

References

[1] Patent: US2007/60623, 2007, A1. Location in patent: Page/Page column 23
[2] Patent: WO2006/36024, 2006, A1. Location in patent: Page/Page column 116; 286
[3] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 12, p. 3925 - 3938
[4] Patent: EP2336107, 2015, B1. Location in patent: Paragraph 0214
[5] Patent: EP1803709, 2007, A1

METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE Suppliers

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16420-39-6, METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATERelated Search:

5-Bromo-6-methoxynicotinic acid methyl ester 5-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 5-Bromoindole-3-carboxaldehyde 5-Bromo-1,2,3,4-tetrahydro-[1,7]naphthyridine 1H-Pyrrolo[2,3-b]pyridine-3-carbonitrile, 5-broMo- 5-BroMo-4-azaindole-3-carbaldehyde 5-BroMo-1H-pyrrole-2-carboxylic acid 1,2-BENZISOXAZOLE, 5-BROMO- 5-Bromo-1-(2methoxyethyl)-1H-indazole METHYL 4,5-DIBROMO-1H-PYRROLE-2-CARBOXYLATE 5-BROMO-1H-PYRROLO[3,2-B] PYRIDINE 5-BroMo-[1,2,4]triazolo[4,3-a]pyrazine 5-bromo-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one 5-BroMo[1,2,4]triazolo[1,5-a]pyrazine 5-BROMOISOQUINOLIN-1(2H)-ONE 5-BROMO-1H-INDOL-3-METHYLAMINE 5-BROMO-1H-INDAZOL-3-AMINE 5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID

METHYL 5-BROMO-1H-PYRROLE-3-CARBOXYLATE

Methyl 5-Bromo-3-pyrrolecarboxylate

5-Bromo-3-(methoxycarbonyl)-1H-pyrrole

5-broMo-pyrrole-3-carboxylic acid Methyl ester

Methyl 5-bromo-1H-pyrrole-3-carboxylate 97+%

2-Bromo-4-(methoxycarbonyl)-1H-pyrrole

1H-Pyrrole-3-carboxylic acid, 5-bromo-, methyl ester

Vonoprazan Impurity 217

16420-39-6