METHYL 2-BROMO-5-FLUOROISONICOTINATE
- Product Name
- METHYL 2-BROMO-5-FLUOROISONICOTINATE
- CAS No.
- 885588-14-7
- Chemical Name
- METHYL 2-BROMO-5-FLUOROISONICOTINATE
- Synonyms
- METHYL 2-BROMO-5-FLUOROISONICOTINATE;Methy 2-broMo-5-fluoropyridine-4-carboxylate;Methyl 2-broMo-5-fluoropyridine-4-carboxylate;3-Fluoro-2-methoxy-7-(trifluoromethyl)pyridine;2-Bromo-5-fluoro-isonicotinic acid methyl ester;4-pyridinecarboxylic acid, 2-bromo-5-fluoro-, methyl ester;Methyl 2-bromo-5-fluoropyridine-4-carboxylate, 2-Bromo-5-fluoro-4-(methoxycarbonyl)pyridine
- CBNumber
- CB42453035
- Molecular Formula
- C7H5BrFNO2
- Formula Weight
- 234.02
- MOL File
- 885588-14-7.mol
METHYL 2-BROMO-5-FLUOROISONICOTINATE Property
- Boiling point:
- 264.0±40.0 °C(Predicted)
- Density
- 1.660±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.76±0.18(Predicted)
- form
- crystalline needles
- color
- Off-white
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M219570
- Product name
- Methyl2-Bromo-5-fluoropyridine-4-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M14555
- Product name
- Methy2-bromo-5-fluoropyridine-4-carboxylate
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- PC57012
- Product name
- Methyl2-bromo-5-fluoroisonicotinate
- Purity
- 95%
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- PC57012
- Product name
- Methyl2-bromo-5-fluoroisonicotinate
- Purity
- 95%
- Packaging
- 250mg
- Price
- $37
- Updated
- 2021/12/16
- Product number
- M14555
- Product name
- Methy2-bromo-5-fluoropyridine-4-carboxylate
- Packaging
- 5g
- Price
- $180
- Updated
- 2021/12/16
METHYL 2-BROMO-5-FLUOROISONICOTINATE Chemical Properties,Usage,Production
Synthesis
67-56-1
885588-12-5
885588-14-7
To a stirred solution of 2-bromo-5-fluoropyridine-4-carboxylic acid (2.8 g, 12.78 mmol) in methanol (30 ml) was slowly added thionyl chloride (7.54 g, 63.9 mmol) at room temperature. The reaction mixture was stirred continuously for 16 hours at room temperature. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The residue was dissolved in water (100 ml) and the pH was adjusted with saturated sodium bicarbonate solution to 8. Subsequently, extraction was carried out with ethyl acetate (2 x 100 ml). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2-bromo-5-fluoroisonicotinate (2.2 g, 73% yield) as a light yellow solid. The results were analyzed by liquid chromatography-mass spectrometry (Method 8): retention time (Rt) = 2.41 min; mass-to-charge ratio (m/z) = 234.07 ([M+H]+).
References
[1] Patent: WO2006/45514, 2006, A1. Location in patent: Page/Page column 38
[2] Patent: WO2017/207813, 2017, A1. Location in patent: Page/Page column 150
METHYL 2-BROMO-5-FLUOROISONICOTINATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 2-BROMO-5-FLUOROISONICOTINATE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 13661411401
- Fax
- 51370935-8011
- yinglv.que@aqbiopharma.com.cn
- Country
- China
- ProdList
- 2930
- Advantage
- 58
- Tel
- 010-60400365-8001 15910885229
- Fax
- 010-60400361
- service@bellenchem.com
- Country
- China
- ProdList
- 4514
- Advantage
- 60
- Tel
- 19983777532
- Fax
- -
- pharmabridge@163.com
- Country
- China
- ProdList
- 501
- Advantage
- 55
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-87782433 18021532344
- Fax
- 025-87782433
- 1345332203@qq.com
- Country
- China
- ProdList
- 4134
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58
- Tel
- 029-86115547 17791676824
- Fax
- 021-51602123
- sales@cochemical.com
- Country
- China
- ProdList
- 4006
- Advantage
- 58