ChemicalBook > CAS DataBase List > 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE

2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE

Product Name: 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE
CAS No.: 6693-08-9
Chemical Name: 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE
Synonyms: 1750830;2,4,6-Trichloro-5-fluoro-1,3-diazine;Pyrimidine, 2,4,6-trichloro-5-fluoro-;2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE ISO 9001：2015 REACH
CBNumber: CB42455312
Molecular Formula: C4Cl3FN2
Formula Weight: 201.41
MOL File: 6693-08-9.mol

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2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE Property

Melting point:: 37-38℃
Boiling point:: 82℃ (11 Torr)
Density: 1.737±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 88.3±25.9℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -8.26±0.39(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C4Cl3FN2/c5-2-1(8)3(6)10-4(7)9-2
InChIKey: XXBZSPPWTVRISV-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=C(F)C(Cl)=N1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-W006901
Product name: 2,4,6-Trichloro-5-fluoropyrimidine
Purity: 99.58%
Packaging: 1g
Price: $112
Updated: 2021/12/16

AK Scientific

Product number: V0432
Product name: 2,4,6-Trichloro-5-fluoropyrimidine
Packaging: 250mg
Price: $115
Updated: 2021/12/16

Apolloscientific

Product number: PC400523
Product name: 2,4,6-Trichloro-5-fluoropyrimidine
Purity: 97%
Packaging: 1g
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 093995
Product name: 2,4,6-Trichloro-5-fluoropyrimidine
Purity: 95+%
Packaging: 250mg
Price: $189
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-6-07
Product name: 2,4,6-Trichloro-5-fluoropyrimidine
Packaging: 1g
Price: $240
Updated: 2021/12/16

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2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE Chemical Properties,Usage,Production

Synthesis

767-80-6

6693-08-9

Part B: Synthesis of 2,4,6-trichloro-5-fluoropyrimidine. Under stirring conditions (note the exothermic reaction), finely powdered 5-fluoro-6-hydroxy-2,4(1H,3H)-pyrimidinedione (74 g, 0.507 mol) was added to phosphorus oxychloride (POCl3, 232 mL, 2.5 mol) in a batch over a period of 30 min. After the addition was completed, the reaction mixture was maintained at 60 °C and N,N-dimethylaniline (65 mL) was slowly added dropwise via syringe. Upon completion of the dropwise addition, the reaction system was heated to 100-110 °C (internal temperature) and the reaction was continued until the reaction was determined to be complete by TLC or other appropriate method, which typically took 4-8 hours. Upon completion of the reaction, the mixture is cooled to room temperature, followed by careful removal of most of the remaining phosphorous trichloride by vacuum distillation at 80-90°C (note: some of the product may be distilled out with POCl3). The residue was slowly poured into ice water (~1 L) and stirred for 30 min. Extraction was carried out with ether (1 x 400 mL, 2 x 150 mL), the organic phases were combined and washed sequentially with water and saturated saline, and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, and the ether was removed by atmospheric pressure distillation to obtain the crude product. The crude product was purified by distillation under reduced pressure to afford the target product 2,4,6-trichloro-5-fluoropyrimidine (28.8 g, 28% yield) as a low melting point white crystalline solid (boiling point 80-85 °C, 12 mmHg).LCMS analysis: (M + H)+: not detected.

References

[1] Patent: WO2009/61879, 2009, A1. Location in patent: Page/Page column 64
[2] Patent: WO2013/82388, 2013, A1. Location in patent: Page/Page column 36; 70

2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE 6693-08-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-12

Dideu Industries Group Limited

Product: 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE 6693-08-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-03

6693-08-9, 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINERelated Search:

2,4-Dichloro-5-fluoropyrimidine 2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE 4,6-Dichloro-5-fluoropyrimidine 2,4,6-Trichloropyrimidine Pyrimidine, 4-chloro-5-fluoro- (9CI)

1750830

2,4,6-Trichloro-5-fluoro-1,3-diazine

Pyrimidine, 2,4,6-trichloro-5-fluoro-

2,4,6-TRICHLORO-5-FLUOROPYRIMIDINE ISO 9001：2015 REACH

6693-08-9

C4Cl3FN2