1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE
- Product Name
- 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE
- CAS No.
- 918524-63-7
- Chemical Name
- 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE
- Synonyms
- Pinacol 2-(4-methylpiperazino)-5-pyridylboronate;(S)-1-[(rp)-2-(dicyclohexylphosphino)ferrocenylethyldi-;2-(4-Methylpiperazino)pyridine-5-boronic acid pinacol ester;2-(N-Methylpiperazin-1-yl)pyridine-5-boronic acid pinacol ester;6-(4-Methyl-1-piperazinyl)pyridine-3-boronic Acid Pinacol Ester;1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)p...;6-(4-Methylpiperazin-1-yl)pyridin-3-ylboronic acid pinacol ester;6-(4-Methylpiperazin-1-yl)pyridine-3-boronic acid, pinacol ester 98%;[6-(4-Methylpiperazin-1-yl)pyridin-3-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1-Methyl-4-5-(4,4,5,5-tetramethyl-1,3,2-dioxaboralan-2-yl)-pyridin-2-ylpiperazine
- CBNumber
- CB42464303
- Molecular Formula
- C16H26BN3O2
- Formula Weight
- 303.21
- MOL File
- 918524-63-7.mol
1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Property
- Melting point:
- 125 °C
- Boiling point:
- 435.2±45.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.41±0.31(Predicted)
- form
- solid
- color
- white
- InChI
- InChI=1S/C16H26BN3O2/c1-15(2)16(3,4)22-17(21-15)13-6-7-14(18-12-13)20-10-8-19(5)9-11-20/h6-7,12H,8-11H2,1-5H3
- InChIKey
- KVQXFNGVIIPCSX-UHFFFAOYSA-N
- SMILES
- N1(C)CCN(C2=NC=C(B3OC(C)(C)C(C)(C)O3)C=C2)CC1
Safety
- Hazard Codes
- C
- Risk Statements
- 22-34
- Safety Statements
- 22-26-36/37/39-45
- RIDADR
- UN2811
- TSCA
- No
- HazardClass
- 6.1
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M3116
- Product name
- 1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 200mg
- Price
- $38
- Updated
- 2025/07/31
- Product number
- M3116
- Product name
- 1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $151
- Updated
- 2025/07/31
- Product number
- M329005
- Product name
- 1-Methyl-4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]piperazine
- Packaging
- 100mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 8H60-1-P6
- Product name
- 6-(4-Methylpiperazin-1-yl)pyridine-3-boronic acid, pinacol ester
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
- Product number
- 092667
- Product name
- 1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxa-borolan-2-yl)pyridin-2-yl)piperazine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $189
- Updated
- 2021/12/16
1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Chemical Properties,Usage,Production
Uses
1-Methyl-4-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]piperazine is used to prepare yrazolopyridine and indazoles as histone lysine methyltransferase EZH2 inhibitors. It is also used to synthesize tetrahydropyrido pyrazines as anaplastic lymphoma kinase inhibitors.
Synthesis
73183-34-3
364794-58-1
918524-63-7
Using 1-(5-bromopyridin-2-yl)-4-methylpiperazine (1.5 g, 5.9 mmol), bis(pinacolato)diboron (1.6 g, 6.5 mmol), potassium acetate (1.8 g, 18 mmol), and Pd(dppf)2Cl2[CH2Cl2] (0.73 g, 0.89 mmol) as raw materials, the mixture was dissolved under nitrogen protection in DMSO (20 mL) and the reaction was stirred at 80 °C overnight. After completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate (EA). The organic phases were combined and concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, v/v=3 to pure ethyl acetate) to afford the target product, 6-(4-methyl-1-piperazinyl)pyridine-3-boronic acid pinacol ester (1.0 g, 56% yield) as a brown solid. Mass spectrometry (MS) analysis showed m/z 304 (M+H)+.
References
[1] Patent: WO2016/73956, 2016, A1. Location in patent: Paragraph 00361
[2] Patent: EP2719697, 2014, A1. Location in patent: Paragraph 0169; 0172; 0173
1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE manufacturers
- Product
- 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE 918524-63-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 2-(4-Methyl-piperazin-1-yl)pyridine-5-boronic acid pinacol ester 918524-63-7
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE 918524-63-7
- Price
- US $100000.00/g
- Min. Order
- 10g
- Purity
- 99%(HPLC)
- Supply Ability
- 20 tons
- Release date
- 2020-06-05